Results 11 to 20 of about 9,812 (159)

Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells 2型糖尿病、细胞功能障碍和氧化还原信号的关系:人胰腺α‐和β‐细胞单细胞基因表达的meta分析

Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022
Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques, Emily Formato, Wenle Liang, Emily Leonard, Alicia R. Timme‐Laragy   +4 more
wiley   +1 more source

Determining the impact of age and sex on the psychophysical and neurophysiological response to thermal pain across the adult lifespan 确定年龄和性别对成年期热痛的心理、生理和神经生理学反应的影响

Journal of Advanced Nursing, Volume 77, Issue 3, Page 1546-1555, March 2021., 2021
Abstract Aims Determine sex‐ and age‐associated psychophysical and neurophysiological differences in the processing of pain across the adult lifespan. Design Preliminary, exploratory, cross‐sectional study. Methods Using psychophysics (to measure intensity and unpleasantness) and functional magnetic resonance imaging blood oxygenation level dependent ...
Sebastian W. Atalla, Ronald L. Cowan, Alison R. Anderson, Mary S. Dietrich, Larkin Iversen, Laura Beth Kalvas, Karen O. Moss, Kathy Wright, Todd B. Monroe   +8 more
wiley   +1 more source

Renoprotective effects of brown adipose tissue activation in diabetic mice 棕色脂肪激活对糖尿病小鼠的肾脏保护作用

Journal of Diabetes, Volume 11, Issue 12, Page 958-970, December 2019., 2019
Highlights This study demonstrates that of brown adipose tissue (BAT) with CL316,243 attenuates the progress of diabetic kidney disease (DKD). Mechanistically, the activation of BAT improved concentrations of circulating adipokines and microRNAs, which further affected the diabetic kidney and reactivated the AMP‐activated protein kinase/sirtuin 1 ...
Ying‐Ying Cai, Hong‐Bin Zhang, Cun‐Xia Fan, Yan‐Mei Zeng, Shao‐Zhou Zou, Chun‐Yan Wu, Ling Wang, Shu Fang, Ping Li, Yao‐Ming Xue, Mei‐Ping Guan   +10 more
wiley   +1 more source

Dual Checkpoint Inhibition with Ipilimumab plus Nivolumab After Progression on Sequential PD‐1/PDL‐1 Inhibitors Pembrolizumab and Atezolizumab in a Patient with Lynch Syndrome, Metastatic Colon, and Localized Urothelial Cancer

The Oncologist, Volume 24, Issue 11, Page 1416-1419, November 2019., 2019
Abstract Immune checkpoint blockade (ICB) is an approved therapy for advanced metastatic mismatch repair (MMR)‐deficient cancer regardless of tissue of origin. Although therapy is effective initially, recurrence rates are significant, and long‐term outcomes remain poor for most patients.
Arthur Winer, Pooja Ghatalia, Nicole Bubes, Fern Anari, Asya Varshavsky, Vineela Kasireddy, Yang Liu, Wafik S. El‐Deiry   +7 more
wiley   +1 more source

An Ultrasound‐Triggered Antibacterial Hydrogel With Integrated Antioxidant and Angiogenic Functions for Infected Wound Care

Rare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Managing diabetic wounds requires simultaneously addressing their infectious, oxidative, and regenerative impairments. To address this, this study integrates a piezoelectric BiOCl@CuSe heterojunction (PFM‐verified) into an injectable F127/HA hydrogel, creating an ultrasound‐responsive smart dressing.
Jiayan Guo, Ximeng Zhang, Bingran Qi, Xingru Zhao, Shi‐Hang Zheng, Kezhu Li   +5 more
wiley   +1 more source

Developing HMME‐Conjugated NIR‐II Activated Carbon Dots Nanospray for the Treatment of MRSA Biofilm Infections in Diabetic Wound via PTT/CDT/SDT

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance.
Liang Zhou, Ning Wang, Zumeng Wang, Pingping Zhang, Yuqin Chu, Yingguang Liu, Wen Liu, Chengwu Zhang, Lili Yan   +8 more
wiley   +1 more source

An Ultrasmall Strontium‐Loaded Polydopamine Nanoformulation for Near‐Infrared‐Enhanced Periodontitis Therapy via Photodynamic Gas‐Promoted Antibacterial and Bone Repair

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria, resulting in the progressive inflammation and destruction of the tissues surrounding teeth. To achieve reprogramming of the infectious microenvironment for periodontitis therapy, a nanoformulation was proposed by loading polydopamine (PDA) with ...
Hao Liang, Yu Liang, Rubiao Qiu, Kunpeng Duan, Jiaxiao Li, Yan Liu, Xiaowen Li, Li Wang, Lingling Liang, Mingyang Jiang, Chenxi Wang, Guojiang Chen, Ming Gao, Xiaojie Li, Tao Qin   +14 more
wiley   +1 more source

Regulating TGO Nucleation and Growth of MCrAlX Coatings via Femtosecond Laser Remelting: The Role of Reactive Elements in the Oxidation Resistance

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT MCrAlX coatings are widely used as bond coats in thermal barrier coating systems to protect turbine blades from high‐temperature oxidation. However, their oxidation resistance is often restricted by uncontrolled microstructures, surface roughness, and aggregation of reactive elements (REs). In this study, high‐repetition‐rate femtosecond laser
Wei Qian, Xiangcheng Li, Yinqun Hua, Xiaofeng Zhang, Yong Feng, Xiaonan Wang, Szymon Tofil, Jie Cai   +7 more
wiley   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

NIR‐Responsive Nano‐Integrated Magnesium Phosphate Cement Promotes Bone Regeneration via Osteoblast‐Exosome‐Osteoclast Crosstalk

Rare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT The limited osteogenic capacity of magnesium phosphate cement (MPC) has constrained its biomedical applications, underscoring the necessity to develop MPC with enhanced physical properties and bone‐forming capabilities. In this study, a multifunctional MPC system was developed by incorporating zoledronic acid‐loaded near‐infrared (NIR ...
Bin Wang, Shun‐Jie Wu, Xin‐Lin Lu, Yong Ge, Yue Zhang, Zhi‐Xiang Ma, Bin Xu, Paul‐K. Chu, Yan‐Bin Zhao   +8 more
wiley   +1 more source