用阿霉素(ADR)和阳离子化牛血清白蛋白(C-BSA)分别诱导大鼠ADR肾病和原位性肾炎模型,发病率各达100%。前者血及肾皮质丙二醛(MDA)明显增高,后者血及肾皮质MDA、还原型谷胱甘肽(GSH)明显增高,超氧化物歧化酶(SOD)明显降低。选用抗氧化剂SOD及具有抗*化作用的中药脚剂阿魏硬钠、赶盖灵芝、敢双醋钠、人参皂苷等分别对模型进行干扰,结果显示治疗组大鼠模型尿蛋白、血生化指标、肾病理损害明显改善,特别是血和肾皮质MDA、GSH明显降低、SOD明显升高。说明ADR肾病和C-BSA原位性肾炎的发生、
doaj
[Exocarpium Citri Grandis formula granules alleviate fatty liver disease in Zebrafish by maintaining iron homeostasis and suppressing lipid peroxidation and ferroptosis]. [PDF]
Zahng Y +5 more
europepmc +1 more source
[Aerobic exercise regulates macrophage polarization and improves insulin resistance in mice: the mediating role of miR-221-3p]. [PDF]
Li N, Zhang L, Guo Q, Zhou Y, Liu C.
europepmc +1 more source
[Research Progress on the Role and Regulatory Mechanisms of Lipid Metabolism in the Osteogenic/Odontogenic Differentiation of Dental Stem Cells]. [PDF]
An K, Xie J, Zhou X.
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[Overwork damages myocardial energy metabolism homeostasis in mice]. [PDF]
Cui J +6 more
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[Research progress on cellular metabolic reprogramming in skin fibrosis]. [PDF]
Qian S, Dai S, Guo C, Xu J.
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siRNAs干扰EBNA1下调EBV阳性鼻咽癌细胞内ALOX12的表达
【目的】 利用RNA干扰技术抑制C666-1细胞中EB病毒核抗原1(EBNA1)的表达,探索氧化应激与抗氧化相关基因的表达变化65377; 【方法】 采用蛋白质印迹证实了能有效抑制EBNA1表达的干扰序列,使用甲基噻唑基四唑(MTT)方法检测C666-1细胞的存活率,利用实时定量PCR芯片技术探索了氧化应激与抗氧化相关基因的转录谱变化,并通过反转录聚合酶链反应(RT-PCR)和蛋白质印迹进行了验证65377;【结果】 EBNA1-1414和EBNA1-1437干扰序列转染C666-1细胞48 h后 ...
doaj
[Molecular imprinting strategies and advances targeting biomembranes]. [PDF]
Yuan XT, Wang L, Chen LX, Hu LH.
europepmc +1 more source
[EVA1A overexpression improves non-alcoholic fatty liver disease in mice by regulating lipid metabolism and promoting lipophagy]. [PDF]
Xu J +8 more
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