Results 51 to 60 of about 1,051 (167)
Research progress in hypothermia-induced RBM3 in ischemia-reperfusion injury of various organs [PDF]
Ischemia-reperfusion injury （IRI） is a complex hemodynamic disorder with high mortality rates and limited treatment options. Mild hypothermia is a widely-accepted treatment method for alleviating ischemic and hypoxic injury， especially in the study of ...
Sun Luxuan, Dang Xiaoping, Sun Zijian
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Research Advances in Sympathetic Remodeling after Myocardial Infarction and Its Significance in Forensic Science#br# [PDF]
, 2019 Sympathetic remodeling after myocardial infarction is presented as denervation, sympathetic nerve sprouting and sympathetic hyperinnervation, and is closely related to ventricular tachyarrhythmias and even sudden cardiac death at convalescence in ...
YU Tian-shui,GE Lu-zou,CAO Ji-min
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血清BDNF 和Ghrelin 水平与冠心病介入术后并发抑郁症的关系
Zhongshan Daxue xuebao. Yixue kexue ban, 2018 【目的】探讨血清脑源性神经营养因子（BDNF）、胃饥饿素（Ghrelin）水平与冠心病介入术后并发抑郁症的联系。【方法】选择2015年3月至2017年2月我院心内科收治的无抑郁症的冠心病患者142例，经PCI术后，按照汉密尔顿抑郁量表（HAMD）评分标准，患者分为PCI术后合并抑郁患者（HAMD评分≥ 7分，抑郁组，n = 45）和PCI术后无抑郁患者（HAMD评分< 7分，非抑郁组，n = 97）。比较两组患者PCI术治疗后3 d血清中BDNF和Ghrelin 水平 ...
余天浩 +6 more
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Mechanisms of neuroprotection by curcumin in acute epileptic rat [PDF]
, 2017 目的：通过腹腔注射大剂量戊四氮建立急性大鼠癫痫模型，运用姜黄素进行干预，观察姜黄素对癫痫大鼠行为的影响和神经元的保护作用及其机制研究。 方法：实验选用健康雄性SD大鼠48只，完全随机分为:姜黄素组、对照组、模型组、实验组，每组12只大鼠，造模前进行相应的预干预，然后通过腹腔注射戊四氮建立急性癫痫动物模型。观察造模后各组大鼠行为学表现；尼氏染色、HE染色观察各组大脑病理变化；Tunnel染色观察各组大脑皮质神经元的凋亡情况；免疫组织化学方法观察姜黄素对海马组织或皮质部分LC3-Ⅱ、Beclin1表达的影响。
杨志荣
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卵泡液中神经营养因子4及卵丘细胞TrkB受体与卵子发育潜能的关系 [PDF]
, 2021 目的探索人卵泡液中神经营养因子4（NT-4）及卵丘颗粒细胞中TrkB受体的表达与卵子发育潜能的关系。方法收集2020年5月至2020年11月在中山大学附属第六医院生殖中心，因男方因素行卵胞浆内单精子注射（ICSI）治疗的63例患者的卵泡液和卵丘颗粒细胞，用ELISA检测卵泡液中NT-4水平，实时荧光定量PCR检测卵丘颗粒细胞中TrkB受体两种不同亚型TrkB-fl和TrkB-t1的表达水平，分析与卵子成熟、受精和胚胎发育的关系。结果卵泡液中NT-4水平与正常受精数（rs=0.250， P=0.048 ...
何姝婧 +5 more
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Advances in the Structure, Separation, Bioactivities and Applications of Probiotic Extracellular Vesicles [PDF]
Extracellular vesicles (EVs), emerging as a novel category of postbiotics, possess various bioactive functions. Probiotic-derived EVs are nanoscale lipid bilayer particles secreted by probiotics into the extracellular matrix, which cannot self-replicate.
ZHONG Hao, TANG Ning, LIU Xiaofeng, CHEN Ling, GUAN Rongfa
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人神经营养素-3 受体基因的扩增及其重组腺病毒载体的构建 [PDF]
, 2005 【目的】构建人神经营养素-3(neurotrophin-3,NT-3)受体(即酪氨酸蛋白激酶受体C, tyrosine protein kinase C, TrkC)基因重组的腺病毒表达载体。【方法】从人脑组织mRNA 中扩增TrkC 基因全长cDNA, 定向克隆于穿梭质粒pShuttle 中, 获得一个带有CMV 启动子的表达盒。再将表达盒与腺病毒骨架DNA ( Adeno-X viral DNA) 体外连接, 形成重组腺病毒质粒(pAd-TrkC)。用pAd-TrkC 转染人胚肾293 ...
刘然义 +6 more
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BDNF 基因修饰淋巴细胞培养上清对 PC12 细胞氧化应激损伤的保护作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】研究脑源性神经营养因子基因(brain-derivedneurotrophicfactor,BDNFgene)修饰淋巴细胞对PC12细胞氧化应激损伤的保护作用。【方法】MTT法检测H2O2和多巴胺(dopamine,DA)对PC12细胞生长的抑制率,Hoechst染色和PI染色流式细胞仪(flowcytometry,FCM)检测H2O2和DA对PC12细胞凋亡的诱导作用。【结果 ...
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Glycosylated serum protein, glycosylated hemoglobin and their interaction on insulin resistance in pregnant women with gestational diabetes mellitus [PDF]
Objective To study glycated serum protein, glycated hemoglobin HbA1C and their interactions, and to analyze their relationship with insulin resistance (IR) in pregnant women with gestational diabetes mellitus.
PEI Yan*, YIN Yanna, MEN Hongqin
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Zhongguo shiyan zhenduanxue, 2007 目的观察骨髓间充质干细胞移植对大鼠大脑中动脉栓塞后神经功能的影响及GDNF的表达。方法采用线栓法大鼠大脑中动脉栓塞（MCAO）模型,颈内动脉移植MSCs,Bederson神经功能评分观察大鼠神经功能,免疫组织化学和原位杂交技术检测GDNF表达。结果MSCs移植可显著提高大鼠局灶性脑缺血后神经功能,缺血周边区GDNF蛋白及mRNA表达水平均高于对照组。结论MSCs移植可促进神经功能恢复,可能通过增加GDNF的表达起到脑保护作用。
钱佳利 +6 more
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