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MiRNA调控脑缺血/再灌注诱导的自噬信号通路研究进展 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban
脑卒中时缺血缺氧致脑组织功能损伤，且缺血后脑组织再恢复血液供应时，大量自由基、钙超载等引起脑缺血/再灌注损伤，进一步加重病情。自噬是一种维持细胞内环境稳态的自我保护机制，但过度自噬引起脑组织损伤。MiRNA为小的内源性非编码RNA分子，通过与其靶基因mRNA的3’ -UTR中的互补序列结合，导致翻译抑制或mRNA降解，从基因水平上调控多种生理活动。MiRNA不仅直接作用于自噬相关蛋白，还可通过多种信号通路，参与缺血/再灌注诱导的自噬调控。但关于miRNA调控脑缺血 ...
刘筱蔼, 罗友根
doaj   +3 more sources

大鼠脑缺血/再灌注过程中脑型葡萄糖转运体在缺血半影区的表达 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 2005
【目的】研究大鼠局灶性脑缺血不同缺血时间和不同再灌注时间的脑梗死体积比、皮质半影区脑型 葡萄糖转运体(GLUT1、GLUT3) 转录水平和蛋白水平的表达。【方法】用线栓法复制大鼠局灶性脑缺血模型, 用 Kontron IBAS2.5 全自动图像分析系统检测脑梗死体积比; 剥取缺血半影区皮质组织, 采用逆转录- 聚合酶链反应 (RT-PCR) , 测定GLUT1、GLUT3 mRNA 水平的变化; 用免疫组织化学半定量测定GLUT1、GLUT3 蛋白水平的变 化。【结果】脑缺血1 h ...
李方成, 陶宗玉, 刘安民, 李军亮, 吴中华, 林吉惠   +5 more
doaj   +2 more sources

Association of glycemic gap with stroke recurrence in patients with ischemic stroke 缺血性卒中患者血糖间隙与卒中复发的相关性

Journal of Diabetes, Volume 15, Issue 9, Page 714-723, September 2023., 2023
Highlights There was a U‐shaped relationship between glycemic gap and stroke recurrence during a long‐term follow‐up in a Chinese ischemic stroke registry. Clinical physicians should remain vigilant in the fluctuation of glucose level and use individualized glucose control strategies in patients with ischemic stroke.
Kang Yuan, Mengdi Xie, Huajuan Hou, Jingjing Chen, Xinyi Zhu, Huaiming Wang, Xiaohao Zhang, Yi Xie, Min Wu, Rui Liu, Xinfeng Liu   +10 more
wiley   +1 more source

Association of alcohol consumption with all‐cause mortality, new‐onset stroke, and coronary heart disease in patients with abnormal glucose metabolism—Findings from a 10‐year follow‐up of the REACTION study 糖代谢异常患者饮酒与全因死亡率、新发卒中以及冠心病的关系——来自REACTION研究10年随访的发现

Journal of Diabetes, Volume 15, Issue 4, Page 289-298, April 2023., 2023
Highlights This long‐term longitudinal study demonstrates the association between alcohol consumption and health outcomes in patients with abnormal glucose metabolism including type 2 diabetes mellitus and prediabetes. Occasional drinking (less than once a week) reduces the risk of all‐cause mortality, while heavy alcohol consumption (≥30 g/day for men
Mengzhao Cui, Fei Li, Xiaokun Gang, Yuan Gao, Xianchao Xiao, Gang Wang, Yujia Liu, Guixia Wang   +7 more
wiley   +1 more source

Global disease burden of stroke attributable to high fasting plasma glucose in 204 countries and territories from 1990 to 2019: An analysis of the Global Burden of Disease Study 204个国家和地区1990‐2019年因空腹血糖升高导致的全球卒中疾病负担:全球疾病负担研究分析

Journal of Diabetes, Volume 14, Issue 8, Page 495-513, August 2022., 2022
Highlights During the past 30 years, globally, the disease burden of stroke burden has decreased substantially; however, the disease burden of stroke attributable to high fasting plasma glucose (HFPG) failed to achieve a significant decline. The population‐attributable fraction of HFPG for stroke burden has been increasing across different regions ...
Yang Liu, Wenxin Wang, Xuewei Huang, Xingyuan Zhang, Lijin Lin, Juan‐Juan Qin, Fang Lei, Jingjing Cai, Bo Cheng   +8 more
wiley   +1 more source

Scalp acupuncture enhances local brain regions functional activities and functional connections between cerebral hemispheres in acute ischemic stroke patients

The Anatomical Record, Volume 304, Issue 11, Page 2538-2551, November 2021., 2021
Abstract This study aimed to explore the changes in functional connections between cerebral hemispheres and local brain regions functional activities in patients with acute ischemic stroke (AIS) treated with International Standard Scalp Acupuncture (ISSA).
Huacong Liu, Yijing Jiang, Ningning Wang, Han Yan, Lanpin Chen, Jingchun Gao, Jiping Zhang, Shanshan Qu, Songyan Liu, Gang Liu, Yong Huang, Junqi Chen   +11 more
wiley   +1 more source

Determining the impact of age and sex on the psychophysical and neurophysiological response to thermal pain across the adult lifespan 确定年龄和性别对成年期热痛的心理、生理和神经生理学反应的影响

Journal of Advanced Nursing, Volume 77, Issue 3, Page 1546-1555, March 2021., 2021
Abstract Aims Determine sex‐ and age‐associated psychophysical and neurophysiological differences in the processing of pain across the adult lifespan. Design Preliminary, exploratory, cross‐sectional study. Methods Using psychophysics (to measure intensity and unpleasantness) and functional magnetic resonance imaging blood oxygenation level dependent ...
Sebastian W. Atalla, Ronald L. Cowan, Alison R. Anderson, Mary S. Dietrich, Larkin Iversen, Laura Beth Kalvas, Karen O. Moss, Kathy Wright, Todd B. Monroe   +8 more
wiley   +1 more source

Auto-titrating continuous positive airway pressure for patients with acute transient ischemic attack: a randomized feasibility trial [PDF]

, 2010
BACKGROUND AND PURPOSE: Transient ischemic attack (TIA) patients are at risk of recurrent vascular events. The primary objectives were to evaluate among TIA patients the prevalence of sleep apnea and among patients with sleep apnea auto-titrating ...
Agostini, Joseph, Brass, Lawrence M., Bravata, Dawn M., Concato, John, Fried, Terri, Gorman, Mark, Klar Yaggi, H., Knight, Herbert J., Lo, Albert, McClain, Vincent, Mohsenin, Vahid, Ranjbar, Noshene, Richerson, George B., Roux, Francoise, Sadarangani, Tanesh, Struve, Frederick, Williams, Linda S., Zygmunt, Lawrence   +17 more
core   +1 more source

髓磷脂抑制因子Nogo-A及其受体在缺血性脑卒中中的作用及机制研究进展 [PDF]

, 2018
作为临床常见的中枢神经系统血管性疾病,缺血性脑卒中具有发病率高、死亡率高、致残率高的\"三高\"特点[1]。从临床资料来看,脑卒中具有非常复杂的病理生理过程,其中一个重要原因是由于脑缺血再灌注后发生大脑局部缺血缺氧,造成组织细胞损伤,比如神经元损伤、轴突生长抑制等,导致运动、感觉、学习和记忆等神经功能障碍[2]。现有研究成果证明,髓磷脂抑制因子Nogo-A及其受体广泛存在于哺国家自然科学基金(81501207,81471265,31570845);;陕西省专项科研计划项目(16JK1645 ...
侯立朝, 孙绪德, 张进, 徐礼鲜, 袁欣, 邓斌   +5 more
core   +1 more source

Comparison on the Treatments of Three Methods for Knee Osteoarthritis [PDF]

, 2017
目的 探讨膝关节骨性关节炎（knee osteoarthritis,KOA）的较佳治疗方案。方法 从双氯芬酸钠治疗组（A组）、正清风痛宁口服治疗组（B组）、正清风痛宁关节腔注射与片剂序贯疗法组（C组）各随机抽取60例病例,比较3组治疗前后疗效、不良反应等指标。结果 3组患者治疗后的Lequesne指数均较治疗前下降（P均〈0.01）;A组治疗后的Lequesne指数与B组差异无统计学意义（P〉0.05）;C组治疗后的Lequesne指数均低于A组与B组（P均〈0.01）。A、B、C ...
方庆全, 陈丰庆, 陈宏
core   +1 more source