Results 11 to 20 of about 7,498 (186)
Mechanisms of bariatric surgery for weight loss and diabetes remission 减重手术减轻体重和缓解糖尿病的机制
Journal of Diabetes, Volume 15, Issue 9, Page 736-752, September 2023., 2023 Highlights Controversial changes in intestinal hormones after bariatric surgery (BS) were summarized. The changes of signaling proteins involved in insulin resistance and the newly proposed changes in growth differentiation factor 15, exosomes, and extracellular vesicles after BS were elucidated.
Mengsha Yin +6 more
wiley +1 more source
The Association of Retinal age gap with metabolic syndrome and inflammation 视网膜年龄差与代谢综合征和炎症的关系
Journal of Diabetes, Volume 15, Issue 3, Page 237-245, March 2023., 2023 Highlights Retinal age gap is a non‐invasive and cost‐effective aging biomarker. Retinal age gap was significantly associated with metabolic syndrome and inflammation. Retinal age gap could be potentially used as a screening tool for metabolic syndrome in large populations.
Zhuoting Zhu +13 more
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 12, Page 806-814, December 2022., 2022 Highlights Metformin activates GDF15 expression, which reduces appetite with induction of weight loss in both diabetic and non‐diabetic patients. GDF15 level is linked and correlated with the progression of diabetic complications including thrombosis, diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy. Abstract Type 2 diabetes mellitus
Hayder M. Al‐kuraishy +8 more
wiley +1 more source
Wireless Communications and Mobile Computing, Volume 2021, Issue 1, 2021., 2021 Clinical named entity recognition (CNER) identifies entities from unstructured medical records and classifies them into predefined categories. It is of great significance for follow‐up clinical studies. Most of the existing CNER methods fail to give enough thought to Chinese radical‐level characteristics and the specialty of the Chinese field.
Yue Wu +6 more
wiley +1 more source
Wireless Communications and Mobile Computing, Volume 2021, Issue 1, 2021., 2021 Machine reading comprehension (MRC) is a challenging natural language processing (NLP) task. It has a wide application potential in the fields of question answering robots, human‐computer interactions in mobile virtual reality systems, etc. Recently, the emergence of pretrained models (PTMs) has brought this research field into a new era, in which the ...
Changchang Zeng +2 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
37例以孤立性头昏为表现的病毒性脑炎特点和误诊分析 [PDF]
目的研究以孤立性头昏为表现的病毒性脑炎患者的临床特点，分析前庭功能检查、脑脊液细胞学等对这类患者的诊断效能。方法收集以孤立性头昏为表现的病毒性脑炎患者37例，健康志愿者10名。收集患者临床资料如眩晕障碍量表（ DHI）评分、头部影像学、脑电图、前庭功能检查、脑脊液常规、生化、细胞形态学、病原学二代测序、误诊情况等。分析各类检查对患者诊断价值的ROC曲线下面积（AUC）。对比治疗前后各检查的变化情况。结果89.19%（33/37）患者的初步诊断存在误诊。64.86%（24/37 ...
周香雪, 许少华, 钟威
core +4 more sources
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 炎症和免疫是脑血管病病理生理的重要部分，其动态变化影响着脑血管病的进程和预后。缺血性卒中急性期的炎症激活造成大脑病灶的炎症损伤，还参与衰老相关的脑小血管病的脑损害，引起血管性痴呆等认知功能障碍。本文就炎症和免疫与脑血管病相互作用机制的研究进展进行综述，以更好地了解和探索免疫调节在治疗中的潜力。
陆正齐
doaj
Improving the inhibitors targeting enterovirus 71 3C proteinase [PDF]
, 2015 手足口病（HFMD）的频繁爆发，给许多婴幼儿带来痛苦甚至导致死亡。目前，没有任何疫苗和抗病毒治疗可用于预防和治疗手足口病。肠道病毒71型（EV71）是引起手足口病的主要病原体，它能够侵入中枢神经系统引起严重的后遗症。3C蛋白酶是EV71病毒复制过程中的一个重要蛋白酶，在EV71的成熟过程和拮抗宿主细胞的先天性免疫反应中有着重要作用。因此，EV713C蛋白酶是一个很好的抗EV71药物靶点。 AG7088最先是针对人病毒3C蛋白酶进行设计的，已被证实可有效抑制EV71病毒活性 ...
吴彩明
core
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
Rare Metals, EarlyView.ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source