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代谢性脑血管病：概念、方法、挑战和未来方向 Cerebro-Metabolic Disease: Concept, Method, Challenge and Future Directions
Zhongguo cuzhong zazhi, 2023 代谢危险因素是导致心脑血管病的重要原因。目前代谢性心血管病已有明确的概念和综合管理体系，而在我国发病率高、异质性强的脑血管病领域，尚未形成统一的代谢性脑血管病的定义和概念。本文综述脑血管病的代谢危险因素，提出代谢性脑血管病的概念和分类，阐述基于多组学技术的多学科、多器官水平的研究方法，介绍近年来涌现的具有心血管获益的代谢药物的特点及未来面临的挑战和研究方向，为代谢性脑血管病的综合管理提供理论依据。 Abstract: Metabolic risk factors are important ...
许杰，王拥军
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Zhongshan Daxue xuebao. Yixue kexue ban, 2021 炎症和免疫是脑血管病病理生理的重要部分，其动态变化影响着脑血管病的进程和预后。缺血性卒中急性期的炎症激活造成大脑病灶的炎症损伤，还参与衰老相关的脑小血管病的脑损害，引起血管性痴呆等认知功能障碍。本文就炎症和免疫与脑血管病相互作用机制的研究进展进行综述，以更好地了解和探索免疫调节在治疗中的潜力。
陆正齐
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脑微血管炎性损伤病理学意义解析与药物调控研究进展 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2018 脑血管病发病率居高不下，临床尚缺乏有效的治疗方法。通过深入解析脑血管病的发病机制来发现潜在的重要药物靶标，这仍然是目前创新药物研发的重要策略。作为大脑必需的氧气和能量来源的重要通道，脑微血管具有区别于外周微血管系统的专有结构和功能属性。 脑微血管是神经血管单元和构成血脑屏障的重要组成部分，也是急、慢性脑血管病的病因源头因素，炎症免疫反应和氧化/硝化应激等因素是造成脑微血管损伤和功能障碍的重要机制。采用能特异性反映临床脑微血管损伤病理过程的体内外疾病模型，结合活体可视化等技术 ...
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脑梗死后再发缺血性卒中与脑出血患者微血管病变及预后的比较 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2006 【目的】探讨脑梗死后再发缺血性卒中与脑出血患者的临床特点、影像学上微血管病变及预后的异同。【方法】连续收集急性复发性卒中的住院病例（初发事件为脑梗死，复发事件包括脑梗死或脑出血），详细记录临床资料。观察脑内微出血及自质病变的严重程度，随访有无严重血管事件及死亡的发生。【结果】175例再发脑梗死患者。19例复发事件为脑出血的患者进入本研究。155例（88．6％）再发脑梗死患者，以及18例（94．7％）脑出血患者存在自质病变。77例（44％）再发脑梗死患者和16例（84．2％）脑出血患者存在脑内微出血 ...
杨淞然 +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1989 本文对365例不同原因的脑血管病变尸检病例作了分析讨论。高血压动脉硬化占全部病例的26.85％。平均年龄58.4岁。脑的病变包括出血、出血伴梗塞及单纯梗塞。其中脑出血最多,但随着脑动脉粥样硬化程度加重,脑出血比例相对地减少,脑出血加梗塞及脑梗塞相对增加。
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中西医结合护理, 2023 Objective Methods 120 elderly patients suffering from aneurysmal subarachnoid hemorrhage and receiving craniotomy from June 2019 to June 2021 were enrolled.
CAO Shuonan (曹硕楠) +2 more
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Journal of Diabetes, Volume 15, Issue 12, Page 1041-1047, December 2023., 2023 Highlights The optimal blood pressure (BP) target in patients with type 2 diabetes mellitus (T2DM) for the management of cognitive decline remains unknown. The Blood Pressure Control Target in Diabetes (BPROAD) Cognitive Study was designed to determine whether intensive BP treatment (systolic BP <120 mm Hg) reduces risk of dementia and mild cognitive ...
The BPROAD Study Group +18 more
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Journal of Diabetes, Volume 15, Issue 11, Page 968-977, November 2023., 2023 Highlights Among 301 studies, diabetes mellitus was the most studied cardiometabolic risk factor. In the network meta‐analysis, cerebrovascular disease had the highest impact (relative risk [RR] 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors.
Alina Binbin Li +9 more
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Journal of Diabetes, Volume 15, Issue 10, Page 838-852, October 2023., 2023 Highlights This review outlines the history of miRNA discovery and its major advances in the field of metabolism. We explore the roles of miRNAs in diabetes‐related cognitive impairment. We innovatively propose that miRNAs also act with a certain organ‐targeting specificity due to the organ‐targeting nature of extracellular vesicles, which may aid ...
Yining Chao +5 more
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Journal of Diabetes, Volume 15, Issue 5, Page 397-408, May 2023., 2023 Highlights Neprilysin (NEP) inhibitors may lead to beneficial effects through inhibition of NEP, which involves impairment of glucose homeostasis through modulation of insulin resistance and the development of pancreatic β cell dysfunction as observed in type 2 diabetes mellitus.
Faisal Holil AlAnazi +8 more
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