Results 11 to 20 of about 7,251 (156)
Journal of Diabetes, Volume 14, Issue 4, Page 247-260, April 2022., 2022 Highlights Phosphoinositide 3‐kinase (PI3K)/Akt signaling is an emerging promising therapeutic target for diabetes. Modulation of the PI3K/Akt signaling pathway, via protein and peptide‐based biologics, parasite‐derived molecules, plant extracts, or through microRNA interactions, will regulate the processes that determine the function of β‐cells and ...
Inah Camaya +2 more
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Journal of Diabetes, Volume 13, Issue 12, Page 1007-1014, December 2021., 2021 Highlights This prospective study compares 15 patients with immune‐checkpoint induced diabetes mellitus (CPI‐DM) with a propensity score matched cohort of patients with other diabetes types. Diabetic ketoacidosis at onset and autoimmune comorbidity is more frequent in CPI‐DM patients. This can be avoided by regular glucose measurements and education on
Sascha R. Tittel +10 more
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Journal of Diabetes, Volume 13, Issue 7, Page 562-571, July 2021., 2021 Highlights Several psychiatric disorders were associated with levothyroxine therapy (LT4). Depression, anxiety disorders, and attention‐deficit/hyperactivity disorder showed the strongest relation to LT4. Thyroid autoimmunity itself (no LT4) was not associated with psychiatric disorders.
Alexander Eckert +9 more
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Autoimmune polyendocrine syndrome type 2 complicated with hyperthyroidism crisis and diabetic acute complications： a case report and literature review [PDF]
, 2023 Objective To enhance clinicians’ diagnosis and treatment capability for autoimmune polyendocrine syndrome type 2 （APS-2），and reduce missed diagnosis and misdiagnosis.
Jian Li, Wu Qinan, Zhao Qiquan, LYU Xinlu
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Diagnostic thinking of renal capillary endothelial cell hyperplasia [PDF]
, 2023 The diseases pathologically manifested with endothelial cell hyperplasia can present with multiple clinical manifestations， which correspond to different types of clinical diseases.
Lü Guangna, Yan Yu
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Ethical Reflection on Standardized Management of Intestinal Microbiota Transplantation [PDF]
, 2017 肠道微生态系统是人体健康所必需的重要且复杂的生物系统。肠道微生态系统的紊乱参与人体多种疾病的发生发展过程。而肠菌移植技术可有效调节肠道菌群，修复失衡的肠道微生态，为当今多种胃肠道及胃肠以外疾病的治疗带来新的突破。然而，目前尚缺乏完整的、系统性的肠菌移植技术管理规范。就肠菌移植技术规范化管理所涉及的内容进行探讨，并从医学伦理学角度思考规范化管理中所涉及的伦理问题，以期推动肠菌移植技术的临床应用。Intestinal microecology is an important and complex ...
任建林 +4 more
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Development of interleukin-21 as a therapeutic drug [PDF]
, 2017 白细胞介素21; (IL-21)是一种具有多效免疫调节活性的细胞因子,参与先天性免疫反应和适应性免疫反应的多个环节,与自身免疫性疾病、肿瘤、病毒感染等疾病的发病过; 程相关。研究表明,在动物模型中通过增强或抑制IL-21的生物学功能对多种疾病具有治疗意义,多项以重组人IL-21为受试药物的临床试验已经开展。本; 文就IL-21的生物学功能,以及IL-21作为生化药物在临床治疗中的研究进展和应用前景进行阐述。Interleukin-21 (IL-21) is a cytokine with broad ...
刘狄彤 +5 more
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Establishment and evaluation of nomogram for differential diagnosis of systemic lupus erythematosus based on laboratory indications [PDF]
Objective·To establish a nomogram for the differential diagnosis of early systemic lupus erythematosus (SLE) and other autoimmune diseases based on laboratory indications, and to evaluate its efficacy.Methods·A total of 535 SLE patients admitted to the ...
CHEN Liubao +4 more
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, 2017 抗中性粒细胞胞质抗体（antineutrophil cytoplasmic autoantibody,ANCA）相关性小血管炎（ANCA associated small vessel vasculiltis,AASV）是以中性粒细胞、单核细胞胞质成分为靶抗原的一组自身免疫性系统性疾病,主要包括肉芽肿性多血管炎、显微镜下多血管炎和嗜酸性肉芽肿性多血管炎。福建省自然科学基金（No ...
彭卫华, 陈凌舟
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