Recent Developments in Stem Cells from Human Exfoliated Deciduous Teeth in the Treatment of Non-oral Diseases [PDF]
, 2023 Stem cells from human exfoliated deciduous teeth (SHEDs) are odontogenic stem cells with strong proliferation ability and multilineage differentiation potential.
JIANG Zhihan, XU Ling
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Role of oxidative stress in trichloroethylene-induced toxicity [PDF]
, 2022 Trichloroethylene (TCE) is a common industrial organic solvent and environmental contaminant. People are exposed to TCE through occupational contact or environmental pollution, which leads to serious human health hazards.
Jinfeng ZHAO +4 more
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Current Status of PD-1/PD-L1 Anti-tumor Therapy and Exploration of the Mechanism of Immune-related Adverse Events [PDF]
, 2022 Programmed cell death protein-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors are a group of immune checkpoint inhibitors. Since May 2006, there have been 10 immune checkpoint inhibitors targeting PD-1 and PD-L1 for tumor treatment. Although PD-
YANG Leiyi, LIN Sang, XIE Qibing, YIN Geng
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Meta-analysis of Curative Effects and Safeties of Baraclude Versus Other Nucleoside Drugs for Treatment of HBeAg-positive Chronic Hepatitis B [PDF]
, 2017 目的：评价博路定和其他抗乙肝病毒核苷酸类药物对核苷初治的乙型肝炎 e 抗原（HBeAg）阳性慢性乙型肝炎（CHB）患者的疗效和安全性。方法：计算机检索 PubMed、Mestre、中国期刊全文数据库（CNKI）、中文科技期刊数据库（VIP）、万方数据库（建库至2015年10月）公开发表的有关博路定和其他抗乙肝病毒核苷酸类药物对核苷初治的 HBeAg 阳性 CHB 患者疗效的随机对照试验（RCTs），并追查已获文献的参考文献。由两名研究者独立筛选文献，提取数据，按照改良后 Jadad 评分标准进行质量评价。
严国鸿 +5 more
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Correlation analysis of bile acid spectrum and thyroid function in patients with autoimmune liver disease [PDF]
"Objective To explore the correlation between bile acid metabolic components and thyroid function indicators in patients with autoimmune liver disease（AILD）.
SONG Keyu，QIAO Runjie，WANG Wenjing，ZHANG Qin，TAN Guolei
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Research progress in the role of M1/M2 polarization of macrophages in different liver diseases [PDF]
Macrophages have strong plasticity and heterogeneity, and can undergo functional transformation in response to different signal stimuli, such as classical activation of M1 type (M1 type polarization) and selective activation of M2 type (M2 type ...
LI Zhengju +5 more
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The association study between the polymorphisms in P53 and MDM2 and the genetic susceptibility of primary hepatocellular carcinoma among Xiamen population [PDF]
, 2015 目的 探讨厦门市P53基因rs1042522位点、MDM2基因rs2279744位点的单核苷酸多态性（SNP）与原发性肝细胞癌（HCC）遗传易感性的关系，为筛检肝癌高危人群，以及进行肝癌一、二级预防提供参考依据。 方法 采用病例-对照研究设计，抽样调查在2011年1月至2014年10月间厦门市综合性三甲医院就诊的肝癌患者和健康对照者。病例组纳入标准：根据HCC诊断依据在调查期间被首次确诊为HCC、年龄≥18岁、现住址与调查地属同一区（县）级范围、无任何其他肿瘤史的患者。排除标准：患有HCC以外的肿瘤 ...
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乳糜泻(celiac disease，CeD)是一种由遗传易感性和环境因素共同作用引起的自身免疫性小肠疾病，主要影响携带HLA-DQ2/DQ8基因的人群。尽管CeD曾被认为是一种罕见病，但其全球发病率逐年上升，已逐渐成为公共卫生问题。中国部分地区已开展CeD的流行病学调查，初步结果显示CeD的发病率并不低。然而，诊断延误仍然普遍存在，未得到及时治疗的患者可能面临营养不良、并发其他自身免疫性疾病，甚至癌症等长期并发症。本文概述CeD的流行病学情况，分析其常见症状及高风险人群，并总结早期筛查和诊断流程 ...
刘秀莹, 陈烨, 龚云英
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Insulin enhances proliferation of hepatoma carcinoma cells by regulating the ubiquitination of glycolytic enzyme pyruvate kinase M2 [PDF]
, 2016 流行病学调查显示，胰岛素增加某些癌症的发病风险。胰岛素可作为一种生长因子促进细胞分裂；当体内有肿瘤细胞或突变细胞存在时，胰岛素可放大癌症的风险。但胰岛素对肿瘤细胞增殖调控的具体机制尚未明确。现有研究表明，丙酮酸激酶PKM2，在肿瘤中呈高表达，不仅是糖酵解限速酶，而且还具有转录因子活性，调控肿瘤细胞的增殖、迁移和侵袭过程，进而促进恶性肿瘤的发生发展。此外，核孤儿受体TR3能通过基因转录、蛋白质相互作用等参与细胞生长、自噬、增殖、凋亡、分化等生理过程，并且其功能发挥与亚细胞定位密切相关 ...
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Establishment and evaluation of nomogram for differential diagnosis of systemic lupus erythematosus based on laboratory indications [PDF]
Objective·To establish a nomogram for the differential diagnosis of early systemic lupus erythematosus (SLE) and other autoimmune diseases based on laboratory indications, and to evaluate its efficacy.Methods·A total of 535 SLE patients admitted to the ...
CHEN Liubao +4 more
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