Results 11 to 20 of about 4,989 (115)

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
wiley   +1 more source

The link between obesity and insulin resistance among children: Effects of key metabolites 儿童肥胖与胰岛素抵抗之间的联系:关键代谢产物的影响

Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023
Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan, Su Wu, Qianqi Liu, Qingqing Zheng, Wei Gu, Xiaonan Li   +5 more
wiley   +1 more source

Noncompartmental pharmacokinetics of three intravenous mycophenolate mofetil concentrations in healthy Standardbred mares

Veterinary Dermatology, Volume 34, Issue 3, Page 222-234, June 2023., 2023
Background – Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA) which acts as an immunosuppressive agent. During the biotransformation of MMF to MPA, additional metabolites including MPA phenol glucuronide (MPAG), MPA acyl glucuronide (AcMPAG) and MPA phenol glucoside (MPG) are formed.
Dylan L. Burroughs, Gwendolen Lorch, Yizhen Guo, Kasey Hill, Eric L. Schroeder, Lynette K. Cole, Mitch A. Phelps   +6 more
wiley   +1 more source

Transdermal drug delivery in horses: An in vitro comparison of skin structure and permeation of two model drugs at various anatomical sites

Veterinary Dermatology, Volume 34, Issue 3, Page 235-245, June 2023., 2023
Background – Oral and parenteral drug delivery in horses can be difficult. Equine‐specific transdermal drug formulations offer improved ease of treatment; development of such formulations requires a deeper understanding of the structural and chemical tissue barrier of horse skin. Hypothesis/Objectives – To compare the structural composition and barrier
Samuel C. Bizley, Jayesh Dudhia, Roger K. W. Smith, Adrian C. Williams   +3 more
wiley   +1 more source

Fasting and refeeding triggers specific changes in bile acid profiles and gut microbiota 禁食和再进食触发胆汁酸谱和肠道微生物群的特异性变化

Journal of Diabetes, Volume 15, Issue 2, Page 165-180, February 2023., 2023
Highlights For the first time, our study contributed a systematic evaluation of bile acid (BA) profiles in plasma, feces and liver tissue and gut microbiota changes triggered by fasting‐refeeding cycle in mice. Our work clearly demonstrated that overnight fasting leads to significant, but reversible changes in BA profiles and gut microbiota composition.
Yi Zhang, Hongyan Qi, Long Wang, Chunyan Hu, Aibo Gao, Qihan Wu, Qiaoling Wang, Huibin Lin, Banru Chen, Xingyu Wang, Shuangyuan Wang, Hong Lin, Weiqing Wang, Yufang Bi, Jiqiu Wang, Jieli Lu, Ruixin Liu   +16 more
wiley   +1 more source

Ceramide changes in abdominal subcutaneous and visceral adipose tissue among diabetic and nondiabetic patients 糖尿病和非糖尿病患者腹部皮下和内脏脂肪组织神经酰胺的变化

Journal of Diabetes, Volume 14, Issue 4, Page 271-281, April 2022., 2022
Highlights The gender‐specific role of sphingolipids in obesity‐related metabolic dysfunctions is unclear. The aim of this study is to identify ceramide species by liquid chromatography‐mass spectrometry that accumulate in central fat in relation to status of diabetes and gender for subjects with a body mass index ≥40 kg/m2 or > 35 kg/m2 with ...
Michelle Brusatori, Michael H. Wood, Stephanie C. Tucker, Krishna Rao Maddipati, S. Kiran Koya, Gregory W. Auner, Kenneth V. Honn, Berhane Seyoum   +7 more
wiley   +1 more source

Chemical and microbiological stability of diluted ceftazidime in three different solutions under three storage temperatures over a 28 day period

Veterinary Dermatology, Volume 32, Issue 5, Page 456-e124, October 2021., 2021
Background – Ceftazidime (CAZ) solutions are being used based on anecdotal reports for otitis externa complicated by multidrug‐resistant Pseudomonas aeruginosa (MDR PA). The chemical and microbiological stability of these proposed compounded solutions have not been evaluated, and likely are affected by the diluent and storage duration or temperature ...
Sarah E. Hoff, Darren J. Berger, Austin K. Viall, Dwayne Schrunk, James O. Noxon   +4 more
wiley   +1 more source

Anthropogenic threats to evolutionary heritage of angiosperms in the Netherlands through an increase in high‐competition environments

Conservation Biology, Volume 34, Issue 6, Page 1536-1548, December 2020., 2020
Abstract Present biodiversity comprises the evolutionary heritage of Earth's epochs. Lineages from particular epochs are often found in particular habitats, but whether current habitat decline threatens the heritage from particular epochs is unknown. We hypothesized that within a given region, humans threaten specifically habitats that harbor lineages ...
Igor V. Bartish, Wim A. Ozinga, Mark I. Bartish, G.W. Wieger Wamelink, Stephan M. Hennekens, Benjamin Yguel, Andreas Prinzing   +6 more
wiley   +1 more source

Faecalibacterium prausnitzii‐derived microbial anti‐inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression 普拉梭菌活性产物‐微生物抗炎分子通过调控细胞紧密连接蛋白表达修复糖尿病小鼠肠道屏障

Journal of Diabetes, Volume 12, Issue 3, Page 224-236, March 2020., 2020
Highlights Diabetic conditions induce compositional dysbiosis of the gut microbiota and impair gut barrier integrity. Diabetic conditions markedly downregulate the abundance of Faecalibacterium prausnitzii in the gut. Under diabetic conditions, microbial anti‐inflammatory molecules from Faecalibacterium prausnitzii restore the gut barrier and ZO‐1 ...
Jihao Xu, Rongrong Liang, Wang Zhang, Kuangyi Tian, Jieyao Li, Xianming Chen, Tao Yu, Qikui Chen   +7 more
wiley   +1 more source

International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation

Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019
目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua, Wenchong Du, Xiaotian Dai, Meiqin Wu, Xianying Cai, Min Shen, Liping Zhu   +6 more
wiley   +1 more source