Results 11 to 20 of about 4,177 (151)

The effect of electroacupuncture at ST25 on Parkinson's disease constipation through regulation of autophagy in the enteric nervous system

open access: yesThe Anatomical Record, Volume 306, Issue 12, Page 3214-3228, December 2023., 2023
Abstract The effectiveness and safety of electroacupuncture (EA) for constipation have been confirmed by numerous clinical studies and experiments, and there are also studies on the efficacy of EA for Parkinson's disease (PD) motor symptoms. However, there are few researches on EA for PD constipation.
Li‐Zhe‐Xiong Song   +8 more
wiley   +1 more source

Toll‐like receptor‐ligand induced thymic stromal lymphopoietin expression in primary equine keratinocytes

open access: yesVeterinary Dermatology, Volume 31, Issue 2, Page 154-e30, April 2020., 2020
Background Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. Hypothesis To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions.
Iva Cvitas   +4 more
wiley   +1 more source

Effects of Nicotinamide on Growth and Secondary Metabolite Synthesis of Monascus purpureus(烟酰胺对紫色红曲菌生长和次级代谢产物合成的影响) [PDF]

open access: yesShipin kexue jishu xuebao, 2021
Monascus purpureus M1 with stable yield of Monacolin K preserved in the Beijing Engineering and Technology Research Center of Food Additive, was used as the starting strain, the effects of nicotinamide addition on the secondary metabolites of Monascus ...
ZHANG Han(张函)   +6 more
doaj   +1 more source

Changes on Mitochondrial DNA Content in Non-small Cell Lung Cancer [PDF]

open access: yes, 2011
Background and objective It has been proven that the mitochondrial DNA (mtDNA) mutations and content change were associated with increasing risk of tumorigenesis. MtDNA content is significantly reduced in most substantive tumors. The aim of this study is
Hongmei WANG, Jigang DAI
core  

Incremental yield of whole‐genome sequencing over chromosomal microarray analysis and exome sequencing for congenital anomalies in prenatal period and infancy: systematic review and meta‐analysis

open access: yesUltrasound in Obstetrics &Gynecology, Volume 63, Issue 1, Page 15-23, January 2024.
ABSTRACT Objectives First, to determine the incremental yield of whole‐genome sequencing (WGS) over quantitative fluorescence polymerase chain reaction (QF‐PCR)/chromosomal microarray analysis (CMA) with and without exome sequencing (ES) in fetuses, neonates and infants with a congenital anomaly that was or could have been detected on prenatal ...
N. Shreeve   +6 more
wiley   +1 more source

Regulation of PI3K and MAPK inhibitors on the activity of FOXO1 and their effect on biological behavior of GIST-T1 gastric stromal tumor cell lines [PDF]

open access: yes, 2015
胃肠道间质瘤(gastrointestinalstromaltumors,GISTs)是消化道最常见的间叶组织肿瘤。目前普遍认为GISTs起源于向cajal细胞分化的原始间叶细胞或幼稚干细胞,具有多向分化特征,可以向平滑肌、神经分化或不定向分化,是一种具有恶性潜能的胃肠道肿瘤,但其确切起源尚不明确。其发病率为1~2/10万人口,似乎正逐渐增加。近年来有研究表明,PI3K(磷脂酰肌醇-3-激酶)和MAPK(丝裂原活化蛋白激酶)信号通路活性在胃肠道间质瘤显著增高 ...
高华
core  

Screening and Cloning the Heavy Metal Tolerance-associated Genes in Avicennia marina (Forsk.) under Cadmium stress by Suppression Subtractive Hybridization [PDF]

open access: yes, 2015
白骨壤(Avicenniamarina)作为红树林的先锋树种,广泛分布于海岸河口的低潮带,其独特的生物学和生态学特性为探索红树植物对重金属耐受性的分子机理提供了最佳的研究对象。红树林生态系统虽然承受大量重金属污染物胁迫,但对重金属污染物却表现出很强的耐受性和抗性,其中白骨壤对重金属的耐受性较其他红树植物更为突出。本研究以红树植物白骨壤为材料,研究重金属污染物镉(Cadmium)胁迫下的白骨壤幼苗基因表达差异,寻找与重金属耐受性相关的候选基因,并为红树植物的基因组研究建立相关的基因文库 ...
张骥诚
core  

中华绒螯蟹铁蛋白基因的克隆及表达分析 [PDF]

open access: yes, 2010
铁蛋白普遍存在于生物体内,具有铁离子解毒和储存等功能。在构建脂多糖刺激的中华绒螯蟹cDNA文库的基础上,获得了中华绒螯蟹铁蛋白基因EsFer的cDNA序列,其全长为1118bp,包含480bp的开放阅读框,推测编码的蛋白质为159氨基酸,其5′和3′端的非编码区分别为178bp和461bp,预测的分子量为18.3ku,理论等电点为5.81,在15~37aa处有一个跨膜螺旋。在5′非编码区核甘酸序列的135~162的位置有个特殊的结构,即铁反应元件(iron response element,IRE ...
付建平   +5 more
core  

MicroRNA-186 inhibits prostate cancer cell proliferation and tumor growth by targeting YY1 and CDK6 [PDF]

open access: yes, 2016
目的 目前的研究已经证实miRNA186在包括非小细胞肺癌、膀胱癌、胰腺导管癌等肿瘤中起着重要的调控作用,但是miRNA186与前列腺癌之间的关系目前还没有研究。本研究的目的主要是探究miRNA186对前列腺癌细胞生物学功能的影响,寻找miRNA186在前列腺癌细胞中作用的下游靶基因,探究其作用的机制。 方法 首先通过荧光定量PCR的方法检测miRNA186在前列腺上皮细胞和3种不同前列腺癌细胞之间的表达情况,然后构建高表达miRNA186的重组质粒载体 ...
陆树
core  

荧光定量PCR与RT-PCR技术检测HCV-RNA的比较观察

open access: yesZhongguo shiyan zhenduanxue, 2000
目的 比较荧光定量 PCR与RT-PCR(定性)检测不同检材中的 HCV-RNA,评价荧光定量PCR技术测定HCV-RNA水平的价值。方法 采用荧光定量PCR及 RT-PCR(定性)技术同时检测了71例血液透析患者的血清、血浆、淋巴细胞、尿液标本中 HCV-RNA。结果 血清、淋巴细胞、尿液标本中 HCV-RNA的荧光定量 PCR检出率(46.38%、85.51%、80.00%),分别高于相应标本中HCV-RNA的RT-PCR(定性)阳性率(24.64、28.99%、20.00%),有统计学意义(P<0.
林潮双   +5 more
doaj  

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