Results 21 to 30 of about 5,216 (129)
Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu +12 more
wiley +1 more source
, 2018 光动力学治疗(photodynamic therapy,PDT)是一种新兴的治疗癌症的方法。对比于传统疗法,PDT具有以下优点:毒性小、收效快[1],对肿瘤细胞具有相对选择性和组织特异性;冷光化学反应,不影响其他治疗,与手术、放疗和化疗等疗法相辅相成;可重复用药,无药物耐受性;治疗时间短,48～72 h即可发挥作用[2]。PDT包含3个可变参数:光敏剂、国家自然科学基金(81600537);;山西省回国留学人员科研资助项目(2017 ...
王毅民 +4 more
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To Ban or Not to Ban: The UK's Hamlet Moment With Farm Antibiotics
Politics &Policy, Volume 53, Issue 6, December 2025.ABSTRACT This article applies the Multiple Streams Framework (MSF) to examine post‐Brexit antimicrobial resistance (AMR) governance in UK agriculture, focusing on the contested regulation of prophylactic antibiotic use in farm animals. The study reveals how Brexit created a structural policy window, yet political and ideological dynamics rendered it ...
George Asiamah
wiley +1 more source
Discovery of small molecule inhibitors of tyrosine kinase RET [PDF]
, 2017 RET（TheREarrangedduringTransfection）是一种受体酪氨酸激酶，与细胞增殖、迁移、分化及神经嵴细胞的生存、肾脏器官的形成、精子发生等过程的信号转导有关。其异常表达、突变和重组与多种癌症的发生发展密切相关，如乳突状甲状腺癌、多发性内分泌腺瘤病2型、髓样甲状腺癌、嗜铬细胞瘤和甲状腺旁腺瘤等。在肺癌方面，RET基因的异常重组KIF5B-RET和CCDC6-RET与约1~2%的肺腺癌相关，其中KIF5B-RET更是占到了其中70~90%的比例，CCDC6-RET约占10~25 ...
杨燕茹
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Veterinary Dermatology, Volume 36, Issue 6, Page 862-869, December 2025.ABSTRACT Background Chronic cases of canine otitis externa (OE) often develop infections with Pseudomonas aeruginosa (PA). Given the organism's high level of resistance, veterinary surgeons often turn to compounded solutions. Limited data describing the stability and potency of compounded ceftazidime (CAZ) solutions are available, which may affect ...
McKenna Snidow +6 more
wiley +1 more source
Veterinary Dermatology, Volume 36, Issue 6, Page 825-837, December 2025.Background: Inhibition of the Janus kinase pathway is an established treatment for allergic dermatitis. Objective: To evaluate the efficacy and safety of ilunocitinib for control of pruritus in dogs with allergic dermatitis in a randomised, double‐masked clinical trial.
Sophie Forster +5 more
wiley +1 more source
野生动物学报, 2022 为探明死亡圈养小熊猫（Ailurus fulgens）体内分离大肠杆菌（Escherichia coli，MT820501）的耐药情况及致病性，对分离菌株进行药敏特性分析，同时以小鼠感染实验检测其致病性。结果显示：该分离菌株对哌拉西林、头孢西丁、头孢曲松、头孢吡肟、美罗培南、哌拉西林-他唑巴坦、氨苄青霉素-舒巴坦、卡那霉素、丁胺卡那、新霉素、米诺环素、左氧氟沙星、呋喃唑酮、多黏菌素B敏感，对大部分β-内酰胺类药物及少部分氨基糖苷类药物耐药；小鼠感染实验结果显示，分离菌株半数致死量为8.42×107 ...
李运莉 1 张东升 1 侯蓉 1 岳婵娟 1 苏小艳 1 燕霞 1 李林 1 杨奎兴 1 彭西 2 刘颂蕊 1
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The Function and Mechanism of AGR2 in Drug Resistant Cancer [PDF]
, 2017 前梯度蛋白2（anteriorgradient-2，AGR2）自发现以来就备受重视，现阶段的研究主要集中于内源性和分泌性AGR2在各种肿瘤中的作用及机制。AGR2蛋白结构特殊，在细胞内定位广泛，功能复杂多样。近期的一些研究证实AGR2可以与IGF-1、HIF-1α、p38等相互作用促进乳腺癌细胞对化疗药物的治疗产生耐药性。但是这些研究对于机制的研究都比较浅显，而且对于AGR2在其他肿瘤的耐药性中是否发挥功能及发挥功能的方式、机制都没有研究。我们想通过我们的研究探究AGR2在不同肿瘤耐药性中发挥的作用 ...
王奉莉
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Veterinary Dermatology, Volume 36, Issue 3, Page 302-313, June 2025.Background – Malassezia pachydermatis (MP) is implicated in severe dermatitis and otitis externa (OE) of companion animals and recently gained attention for its increasing resistance to azole compounds. For this reason, developing novel therapeutic strategies is of great interest. In a previous work, we used reference yeast isolates to evaluate several
Costanza Spadini +11 more
wiley +1 more source
多药耐药基因转染人骨髓间充质干细胞及对其化疗保护作用的实验研究
Zhongguo shiyan zhenduanxue, 2007 目的探讨逆转录病毒介导多药耐药基因（mdr1）体外转染人骨髓间充质干细胞（MSCs）能否提高其对化疗药物的耐受性。方法采用percoll密度梯度离心法自骨髓中分离MSC并进行纯化和扩增;脂质体转染法将携带有mdr1基因的逆转录病毒载体导入293T包装细胞,获得的病毒上清感染MSC,流式细胞术测定mdr1基因编码产物P-糖蛋白（P-g170）的表达水平;罗丹明（Rh123）排泌试验检测P-g170的功能活性;MTT法测定转染MSC对化疗药物耐受性。结果mdr1基因导入骨髓MSC后稳定表达P ...
叶明珠, 韩丽英, 岳鑫, 李荷莲
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