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基于质谱的单细胞蛋白质组学分析方法及应用

Se pu = Chinese journal of chromatography, 2021
细胞是生命体的最小组成单位,遗传及外部环境等因素使单细胞异质性广泛存在于众多生物体中。传统的生物学实验获得的结果多是大量细胞的平均测量值,因此在单细胞层面开展研究对于精确理解细胞的生长发育以及疾病的诊断与治疗至关重要。而作为重要的细胞和生命活动的执行者,蛋白质由于其不具备扩增特性,且种类繁多、丰度低、动态分布范围宽,与核酸等其他生物大分子相比,其单细胞组学研究相对滞后。而在所有的检测手段中,荧光检测以及电化学分析方法具有极高的灵敏度,但是囿于其研究通量有限,以及电化学活性依赖 ...
Shaojie Qin, Yu Bai, Huwei Liu
semanticscholar   +1 more source

SARS‐CoV‐2 infection as cause of in‐utero fetal death: regional multicenter cohort study

Ultrasound in Obstetrics &Gynecology, Volume 62, Issue 6, Page 867-874, December 2023., 2023
ABSTRACT Objective Placental infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can lead to placental insufficiency and in‐utero fetal death (IUFD). The objective of this study was to confirm and quantify the extent to which fetoplacental infection with SARS‐CoV‐2 is a cause of fetal death.
M. Nkobetchou, M. Leruez‐Ville, T. Guilleminot, N. Roux, G. Petrilli, F. Guimiot, M.‐H. Saint‐Frison, I. Deryabin, Y. Ville, V. Faure‐Bardon   +9 more
wiley   +1 more source

Decreased in n‐3 DHA enriched triacylglycerol in small extracellular vesicles of diabetic patients with cardiac dysfunction 糖尿病合并心脏功能障碍患者细胞外小囊泡中n‐3 DHA 富集的三酰甘油减少

Journal of Diabetes, Volume 15, Issue 12, Page 1070-1080, December 2023., 2023
Highlights Lipid profiles of small extracellular vesicles (sEVs) in patients with diabetes or diabetic cardiovascular disease are rarely reported. n‐3 docosahexaenoic acid (DHA)‐enriched triacylglycerol (TG) was found to decrease in sEVs from serum of patients with diabetic cardiovascular disease (DM‐CAD).
Wei Ding, Xuejuan Zhang, Dandan Xiao, Wenguang Chang   +3 more
wiley   +1 more source

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
wiley   +1 more source

Increased glutamate in type 2 diabetes in the Korean population is associated with increased plasminogen levels 韩国2型糖尿病患者谷氨酸升高与纤溶酶原水平升高有关

Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023
Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee, Jeong Won Yeom, Ji Ho Yun, Han Byul Jang, Min‐Gyu Yoo, Hyo‐Jin Kim, Soo Kyung Koo, Hye‐Ja Lee   +7 more
wiley   +1 more source

MsaH2A.W is identified response to salt tolerance in Miscanthus sacchariflorus

GCB Bioenergy, Volume 15, Issue 8, Page 1058-1073, August 2023., 2023
To study the underlying genetic basis of Miscanthus adaptation to salt stress, the transcriptome variations of Miscanthus sinensis, Miscanthus sacchariflorus and their hybrid were analysed using RNA‐seq technology under salt treatment. According to the expression pattern of known salt‐tolerant genes, a histone variant gene MsaH2AW of M.
Ting Yu, Yancui Wang, Pingping Xu, Senan Cheng, Xinwei Hou, Guofeng Geng, Zhiqiang Pan, Shukai Wang, Dusheng Lu, Shubo Gu, Xitong Xu, Zhixin Liu, Cuixia Chen   +12 more
wiley   +1 more source

Insights from basic adjunctive examinations of GCK‐MODY, HNF1A‐MODY, and type 2 diabetes: A systemic review and meta‐analysis GCK‐MODY、HNF1A‐MODY和2型糖尿病的基础辅助检查的见解:一项系统回顾和meta分析

Journal of Diabetes, Volume 15, Issue 6, Page 519-531, June 2023., 2023
Highlights For distinguishing glucokinase maturity‐onset diabetes of the young (GCK‐MODY) from hepatocyte nuclear factor 1‐α MODY (HNF1A‐MODY), total triglycerides may help during the follow‐up period. In order to discriminate GCK‐MODY from MODY‐like type 2 diabetes, high‐sensitivity C‐reactive protein may be a suitable indicator in the early stage ...
Jing Liu, Xinhua Xiao, Qian Zhang, Miao Yu   +3 more
wiley   +1 more source

Equine allergic skin diseases: Clinical consensus guidelines of the World Association for Veterinary Dermatology

Veterinary Dermatology, Volume 34, Issue 3, Page 175-208, June 2023., 2023
Abstract Background Allergic skin diseases are common in horses worldwide. The most common causes are insect bites and environmental allergens. Objectives To review the current literature and provide consensus on pathogenesis, diagnosis, treatment and prevention. Materials and Methods The authors reviewed the literature up to November 2022.
R. Marsella, S. White, V. A. Fadok, D. Wilson, R. Mueller, C. Outerbridge, W. Rosenkrantz   +6 more
wiley   +1 more source

Effect of sodium‐glucose cotransporter 2 inhibitors on the rate of decline in kidney function: A systematic review and meta‐analysis 钠‐葡萄糖共转运蛋白2抑制剂对肾功能下降速度的影响:系统综述和meta分析

Journal of Diabetes, Volume 15, Issue 1, Page 58-70, January 2023., 2023
Highlights Sodium/glucose cotransporter‐2 inhibitors (SGLT‐2i) showed an important renoprotective effect on sustained administration, regardless of the presence of diabetes, the baseline estimated glomerular filtration rate (eGFR) and different types of SGLT‐2i. There was an acute decline of eGFR in the initial administration (4.02 ml/min/1.73 m2), and
Yanbei Duo, Junxiang Gao, Tao Yuan, Weigang Zhao   +3 more
wiley   +1 more source

Protein pyrrole adducts are associated with elevated glucose indices and clinical features of diabetic diffuse neuropathies 蛋白质吡咯加合物与血糖指数升高和糖尿病弥漫性神经病的临床特征相关

Journal of Diabetes, Volume 14, Issue 10, Page 646-657, October 2022., 2022
Highlights The protein pyrrole adducts in both plasma and urine correlated well with glucose indices, namely fasting blood glucose (FBG) and glycate hemoglobin A1c (HbA1c). Elevated plasma pyrrole adducts was related to positive distal symmetric polyneuropathy (DSPN) symptoms and a high resting heart rate.
Xiao Chen, Zhuyi Jiang, Lianjing Zhang, Wei Liu, Xiaohu Ren, Luling Nie, Desheng Wu, Zhiwei Guo, Weimin Liu, Xifei Yang, Yan Wu, Zhen Liang, Peter Spencer, Jianjun Liu   +13 more
wiley   +1 more source