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[Moxibustion Inhibits Postmenopausal Bone Loss by Regulating the Metabolism of Gut Microbiota-Related Serotonin]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
目的 探究中医艾灸疗法对卵巢切除的雌激素缺乏小鼠骨代谢调控作用并探究其机制。 方法 将12 周龄雌性C57BL/6J小鼠随机分为假手术组（SHAM）、卵巢切除术组（OVX）、卵巢切除术合并广谱抗生素干预组（OVX-A）、卵巢切除术后艾灸干预组（OVX-M）及卵巢切除术后广谱抗生素干预同时艾灸组（OVX-A-M），每组5只。手术后4周，分别给予广谱抗生素和（或）艾灸干预4周后处死取材。采用Micro-CT检测各组小鼠股骨远端骨量并进行参数分析〔包括骨体积分数（bone volume/tissue ...
Huang X, Camilo Alberto PG, Xu H, Lu L, Yang H, Li N, Wen Q.   +6 more
europepmc   +2 more sources

血清淀粉样蛋白A1(SAA1)与肿瘤疾病发展的综述

肿瘤研究与治疗, 2022
血清淀粉样蛋白A1(SAA1)是血清淀粉样蛋白A家族的其中一种蛋白，其本质属于一种载脂蛋白。另外SAA1还是一种急性期蛋白，在炎症和组织损伤反应中高度表达。这种蛋白可能是某些肿瘤的潜在生物标志物。在SAA1与肿瘤发展的关系方面，目前许多研究者对此进行了深入的实验研究和理论探索，目的旨在为一些肿瘤疾病的诊断提供新的思路，本文就近些年来对SAA1与肿瘤发展的研究进展加以综述。
发亮 唐
semanticscholar   +1 more source

固相萃取-气相色谱-串联质谱法同时测定武汉市普通人群血清中35种有机氯农药与多氯联苯

Se pu = Chinese journal of chromatography, 2022
有机氯农药(OCPs)和多氯联苯(PCBs)是两类重要的持久性有机污染物,可在环境介质中长期存在,并通过多种途径进入人体,导致人体的高暴露风险。OCPs和PCBs对人体存在诸多健康危害,精准定量人体内OCPs和PCBs的暴露水平是健康效应评价的关键。该研究基于固相萃取-气相色谱-串联质谱联用技术(SPE-GC-MS/MS)建立了同时检测100 μL血清中35种OCPs和PCBs的分析方法。血清样品经尿素沉淀蛋白后,采用Oasis® HLB小柱净化,正己烷-二氯甲烷混合溶液(1∶1, v/v)洗脱 ...
Xiang Li, Limei Wang, Lulu Song, Zhengce Wan, Jing Kou, M. Zhang, Yongman Lü, Youjie Wang, Surong Mei   +8 more
semanticscholar   +1 more source

血清和血清外泌体的蛋白质组分析及其在肝内胆管癌中的应用

Se pu = Chinese journal of chromatography, 2021
外泌体是由各种类型细胞在正常或非正常生理情况下分泌释放至细胞外且携带多种生物活性分子的细胞外囊泡,在细胞间通讯和免疫应答等生物过程中发挥着重要作用。肝内胆管癌是一种胆道上皮恶性肿瘤,早期无明显临床症状且生存率较低,目前常用的诊断手段包括依赖于影像设备的诊断方式和灵敏度及特异性较低的诊断标志物等,这些手段的不足对发展新的特异性标志物提出了需求。该文对血清中的外泌体进行了分离和表征,并采用液相色谱-质谱技术针对健康组与肝内胆管癌患者组的血清样本和血清外泌体样本进行了无标记定量蛋白质组学分析 ...
Kaige Yang, Weiwei Wang, Yan Wang, Chao Yan   +3 more
semanticscholar   +1 more source

Decreased in n‐3 DHA enriched triacylglycerol in small extracellular vesicles of diabetic patients with cardiac dysfunction 糖尿病合并心脏功能障碍患者细胞外小囊泡中n‐3 DHA 富集的三酰甘油减少

Journal of Diabetes, Volume 15, Issue 12, Page 1070-1080, December 2023., 2023
Highlights Lipid profiles of small extracellular vesicles (sEVs) in patients with diabetes or diabetic cardiovascular disease are rarely reported. n‐3 docosahexaenoic acid (DHA)‐enriched triacylglycerol (TG) was found to decrease in sEVs from serum of patients with diabetic cardiovascular disease (DM‐CAD).
Wei Ding, Xuejuan Zhang, Dandan Xiao, Wenguang Chang   +3 more
wiley   +1 more source

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
wiley   +1 more source

The link between obesity and insulin resistance among children: Effects of key metabolites 儿童肥胖与胰岛素抵抗之间的联系:关键代谢产物的影响

Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023
Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan, Su Wu, Qianqi Liu, Qingqing Zheng, Wei Gu, Xiaonan Li   +5 more
wiley   +1 more source

Plasma mitochondrial DNA is elevated in maternal serum at first trimester and may serve as a biomarker for prediction of gestational diabetes mellitus 血浆线粒体DNA在妊娠早期孕妇血清中升高，可能成为预测妊娠期糖尿病的生物标志物

Journal of Diabetes, Volume 15, Issue 12, Page 1095-1102, December 2023., 2023
Highlights In the first trimester, the plasma mitochondrial DNA (mtDNA) was higher in women who developed gestational diabetes mellitus (GDM) than in women who did not develop GDM during their pregnancy. The increased levels of plasma mtDNA were independent of age and fasting plasma glucose levels in the first trimester.
Dushyant Kumar Sahu, Jessy Abraham
wiley   +1 more source

Sensitivity of a Hymenoptera serological immunoglobulin (Ig)E assay for the diagnosis of venom hypersensitivity in dogs

Veterinary Dermatology, Volume 34, Issue 6, Page 543-553, December 2023., 2023
Background – Hymenoptera envenomation with honey bee (Apis mellifera) and paper wasp (Polistes spp.) may cause life‐threatening anaphylaxis in dogs. In human patients, clinical history, intradermal testing (IDT) and measurement of allergen‐specific serological immunoglobulin (Ig)E (sIgE) are used to support a diagnosis of Hymenoptera venom ...
Hilary H. Chan, Amanda K. Burrows, Giselle Hosgood, Rudayna Ghubash   +3 more
wiley   +1 more source

Glycosylated fibronectin improves first‐trimester prediction of pre‐eclampsia

Ultrasound in Obstetrics &Gynecology, Volume 62, Issue 4, Page 512-521, October 2023., 2023
ABSTRACT Objective To determine whether maternal serum glycosylated fibronectin (GlyFn) level in the first trimester increases the sensitivity of the Fetal Medicine Foundation (FMF) triple test, which incorporates mean arterial pressure, uterine artery pulsatility index and placental growth factor, when screening for pre‐eclampsia (PE) in an Asian ...
S. Moungmaithong, X. Wang, C. S. L. Lau, A. W. T. Tse, N. M. W. Lee, H. H. Y. Leung, L. C. Poon, D. S. Sahota   +7 more
wiley   +1 more source