Study on establishing an approach for rapid screening RXRα ligands from medicinal herbs [PDF]
, 2016 维甲酸X受体α（RXRα）是研究抗癌药物的重要靶点之一，其配体Targretin已由FDA批准用于治疗皮肤癌，目前已知的天然RXRα小分子配体非常有限，因此建立一种新的活性筛选模型从中药及天然产物中快速发现以RXRα为活性靶点的新型小分子配体具有重要意义。 前期研究发现黄牛木属植物中的氧杂蒽酮类化合物能够抑制RXRα的转录活化功能，其中，CF-31能够直接与RXRα通过疏水性相互作用的方式结合，因此，本研究以黄牛木属植物黄牛木和红芽木为拟建立活性筛选体系的候选药材，对其60%乙醇水提取物经大孔树脂90 ...
陈虹
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Rare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man +7 more
wiley +1 more source
Resonance Light-Scattering Spectra of Bovine Serum Albumin and Its Analytical Application [PDF]
, 1999 研究了牛血清白蛋白水溶液本身的共振光散射光谱信号， 基于其光谱强度与牛血清白蛋白的浓度呈线性相关的现象， 初步建立了一种步骤简单的测定方法.The resonance light-scattering spectra of BSA have been studied using an ordinary spectrofluorometer.The signal intensity of BSA is enhanced with the increase of concentration of BSA ...
朱庆枝 +4 more
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Optimization of preparation process and molecular characterization of limonin-albumin nanoparticles using response surface methodology [PDF]
[Objective] The construction of limonin-albumin nanoparticles provides a theoretical basis for the further application of limonin. [Methods] Limonin-albumin nanoparticles were prepared by desolvation-chemical crosslinking method using bovine serum ...
CHEN Deqiang +4 more
core +1 more source
Several Original Applications of Water-soluble Phthalocyanines as Optical Probes in Analytical Sciences [PDF]
, 2016 酞菁化合物大多性质稳定、易于合成、结构可修饰性强，可引入各类活性基团从而获得具有各种功能的衍生物。尤为难得的是，中心配位原子为反磁性的金属酞菁化合物大多具有荧光量子产率高、荧光发射在红色区域且可进行长波激发（因而可有效避开背景荧光和散射光的干扰）等优良荧光特性。本学位论文围绕金属酞菁作为光学分子探针在分析科学的应用而展开，共六章。 第一章首先对酞菁的结构、基本性质与应用作了简要介绍。重点阐述酞菁在分析科学领域的应用，包括酞菁在催化动力学分析中的应用、酞菁作为光学探针的应用以及酞菁作为光学成像探针的应用等。
郭梦林
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Spectroscopic Method Combined with Molecular Docking Technique to Study the Interaction of Limonin with Bovine Serum Albumin [PDF]
In order to study the interaction between limonin (LM) and bovine serum albumin (BSA), in this paper, the interaction mechanism between LM and BSA was explored by ultraviolet (UV) spectroscopy, fluorescence spectroscopy and molecular docking technology ...
Qingliang DONG, Xinfu LIANG
core +1 more source
Synthesis and Characterization of [Ni(Hlact)_2(phen)]·2H_2O and Its Interaction with BSA Studied by Fluorescence Spectroscopy [PDF]
, 2013 利用溶液法合成了配合物[nI(HlACT)2(PHEn)]·2H2O(1),并对该配合物进行了元素分析、红外光谱和X-射线单晶衍射表征。通过荧光光谱法研究了不同温度下配合物1与牛血清白蛋白相互作用时的荧光强度的变化,计算了在不同温度下,配合物1与牛血清白蛋白(bSA)的结合常数、结合位点数以及热力学函数,并进一步讨论了配合物1与bSA相互作用时的作用力类型和两者之间的距离。结果表明,配合物1对牛血清白蛋白的荧光猝灭为静态猝灭过程,它与牛血清白蛋白的相互作用有一个位点,结合常数的平均值5.06x105l ...
周朝晖 +3 more
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Objectives：The purposes of the study were to investigate the incidence of pressure ulcer of orthopedics patients undergoing selective operation, and to identify the risk factors of pressure ulcer.Methods: A prospective cohort study was employed in this ...
Huang, Shao-hua +3 more
core +2 more sources
Malignancy-associated metabolic profiling of human glioma cell lines using 1H NMR spectroscopy [PDF]
, 2015 胶质瘤恶性转化的原因和机制不明，给临床诊疗带来极大困难。越来越多的研究表明肿瘤恶性转化与细胞代谢紊乱密切相关，但胶质瘤恶性转化相关的细胞代谢特点目前尚不清楚。因此，探寻不同恶性程度胶质瘤细胞的代谢轮廓，将有助于开发监测胶质瘤恶性进展的非入侵式生物标志物和靶向代谢通路的治疗策略。本研究收集5种不同病理级别瘤组织来源的人脑胶质瘤细胞系（CHG5／SHG44／U118／U87／U251），其中CHG5和SHG44为WHOII级来源；U118,U87和U251为WHOIV级来源。体外培养后，首先通过侵袭能力 ...
邵巍
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, 2010 为认识我国淡水鱼类烂鳃病的病原以及柱形病在我国的发生情况,实验从发生烂鳃病的病鱼中分离细菌性病原,经过生理生化特性分析以及是否在含托普霉素的Shieh培养基中生长并形成黄色假根状菌落,是否产生降解明胶和硫酸软骨素的酶类等特性的鉴定,并结合16SrDNA序列分析,证实柱状黄杆菌(Flavobacterium columnare)是所分离的烂鳃病的病原。同时,研究也证实20世纪曾经命名为烂鳃(Gill-rot)病病原的鱼害黏球菌(Myxococcus piscicola Lu,Nie & Ko,1975 ...
姚卫建 +7 more
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