Results 11 to 20 of about 3,855 (101)

环状RNA-SCAF8通过miR-93-5p/TXNIP通路促进血管内皮细胞焦亡

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2023
目的 探究环状RNA（circRNA）-SR相关CTD相关因子8（SCAF8）在高糖环境下对血管内皮细胞焦亡发挥的作用及机制。 方法 将来源于人脐静脉内皮细胞分为正常对照组、高糖对照组分别置于5、33 mmol/L葡萄糖浓度的细胞培养基培养，RNA对照组、circRNA-SCAF8抑制组、微RNA（miR）-93-5p过表达组和miR-93-5p抑制组分别在高糖环境下加入无功能siRNA、circRNA-SCAF8抑制分子、miR-93-5p过表达分子和miR-93-5p抑制剂。采用细胞计数试剂盒8 ...
Bing Wang, Xinyu Yu, Tian-chi Chen, Chenyang Qiu, Yangyan He, Wei Lu, Xiangtao Zheng, Zi-heng Wu   +7 more
semanticscholar   +1 more source

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
wiley   +1 more source

Successful surgical removal of a pheochromocytoma in a mare via trans‐costal approach

Equine Veterinary Journal, Volume 55, Issue 6, Page 1012-1020, November 2023., 2023
Abstract Background Pheochromocytomas have been previously reported in horses, but successful antemortem diagnosis and surgical removal without recurrence of clinical signs have not been described. Objective To report the clinical presentation, diagnostic evaluation, surgical technique, anaesthetic management and post‐operative care of a mare diagnosed
Thomas J. O'Brien, Lynn M. Pezzanite, Elizabeth V. Acutt, Allison C. Vilander, Diana M. Hassel, Rachel C. Hector, Dean A. Hendrickson   +6 more
wiley   +1 more source

Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy 纳豆激酶对糖尿病视网膜病变微血管病变和神经炎症的保护作用

Journal of Diabetes, Volume 15, Issue 10, Page 866-880, October 2023., 2023
Highlights Nattokinase rescued endothelial dysfunction and pericyte loss in the diabetic retina. Nattokinase attenuated diabetes‐induced retinal inflammation and neurodegeneration. High mobility group box 1 signaling was involved in nattokinase‐mediated retinal protection.
Zijing Huang, Wai Kit Chu, Tsz Kin Ng, Shaolang Chen, Jiajian Liang, Chong‐Bo Chen, Yanxuan Xu, Biyao Xie, Shuping Ke, Qingping Liu, Weiqi Chen, Dingguo Huang   +11 more
wiley   +1 more source

Mechanisms of diabetic foot ulceration: A review 糖尿病足溃疡发生机制综述

Journal of Diabetes, Volume 15, Issue 4, Page 299-312, April 2023., 2023
Highlights With the increase in the elderly population, diabetic foot ulcers (DFUs) severely affect human health and societies worldwide. They will pose significant medical, social, and socioeconomic challenges. Reviewing the existing studies on the pathogenesis of DFUs, most of them focus on clinical nursing and treatment.
Haibo Deng, Binghui Li, Qian Shen, Chenchen Zhang, Liwen Kuang, Ran Chen, SiYuan Wang, ZhiQiang Ma, Gongchi Li   +8 more
wiley   +1 more source

Effects of SGLT2 inhibitors on patients with diabetic kidney disease: A preliminary study on the basis of podocyturia SGLT2抑制剂对糖尿病肾病患者的影响:基于尿足细胞的初步研究

Journal of Diabetes, Volume 14, Issue 4, Page 236-246, April 2022., 2022
Highlights Diabetic kidney disease is a progressive disease with the pathology of glomerular damage and loss of podocytes. Sodium glucose cotransporter 2 inhibitors (SGLT2i) can be expected to decrease the amount of podocyte excretion. Male patients receiving SGLT2i have better diabetic kidney disease‐related parameters and podocyturia levels. Abstract
Emre Durcan, Serbay Ozkan, Halil Ibrahim Saygi, Mevlut Tamer Dincer, Ozge Polat Korkmaz, Serdar Sahin, Cebrail Karaca, Cem Sulu, Alev Bakir, Hande Mefkure Ozkaya, Sinan Trabulus, Elif Guzel, Nurhan Seyahi, Mustafa Sait Gonen   +13 more
wiley   +1 more source

Dermoscopic evaluation of normal canine skin with a handheld dermoscope

Veterinary Dermatology, Volume 36, Issue 5, Page 593-601, October 2025.
Background – Dermoscopy is a noninvasive diagnostic tool that provides a magnified view of skin structures. While dermoscopy is described for certain canine dermatological diseases, large‐scale studies evaluating normal skin are lacking. Hypothesis/Objective – This study aimed to correlate dermoscopic findings with histopathological results in healthy ...
Rachael Loek, David Gardiner, George Moore, Ashfaq Marghoob, Carine Laporte   +4 more
wiley   +1 more source

TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells [PDF]

, 2016
溶血卵磷脂（lysophosphatidylcholine，lysoPC）是氧化低密度脂蛋白（oxidizedlow-densitylipoprotein，ox-LDL）的主要成分。早期的研究表明，lysoPC可诱导人冠状动脉平滑肌细胞（humancoronaryarterysmoothmusclecells，HCASMCs)凋亡，但具体机制尚不清楚。近期，我们通过细胞活力测定，流式细胞术，共聚焦显微镜及分子生物学手段对lysoPC作用的分子机制进行研究发现，lysoPC可引发细胞外钙离子内流 ...
王渊
core   +1 more source

The Role of Matrine and Mitogen-Ativated Protein Kinase/Extracellular Signal-Regulated Kinase Signal Transduction in the Inhibition of the Proliferation and Migration of Human Umbilical Veins Endothelial Cells Induced by Lung Cancer cells [PDF]

, 2009
Background and objective Matrine, one of the major alkaloid components of the traditional Chinese medicine Sophora roots, has a wide range of pharmacological effects including anti-inflammatory activities, growth inhibition and induction of cell ...
Jinchang LU, Ming BAI, Mingli TU, Ping CHENG, Qiang LUO, Xianjun LIU   +5 more
core  

血管内皮细胞生长因子表达肿瘤微血管密度的意义

Zhongguo shiyan zhenduanxue, 2006
目的应用小鼠肿瘤模型,通过血管内皮细胞生长因子表达肿瘤微血管密度,了解血管抑素抑制肿瘤血管新生。方法免疫组化测定血管内皮细胞生长因子,通过肿瘤微血管密度表达肿瘤血管生长的情况,探讨肿瘤血管新生发生的可能机制。结果血管内皮细胞生长因子在肿瘤中的表达较少,主要表达在内皮细胞中。结论血管内皮细胞生长因子可以表达肿瘤血管密度,证明血管抑素可以抑制肿瘤血管新生。
孙海侠, 范恩学, 李爱丽
doaj