Results 91 to 100 of about 1,701 (142)

分泌型卷曲相关蛋白1通过Wnt/β-catenin通路抑制血管平滑肌细胞钙化

Zhongshan Daxue xuebao. Yixue kexue ban
目的探讨分泌型卷曲相关蛋白1（SFRP1）通过Wnt/β-catenin通路对血管平滑肌细胞成骨分化的影响。方法使用原代人主动脉血管平滑肌细胞，转染SFRP1小干扰RNA（siSFRP1）敲低SFRP1在人血管平滑肌细胞表达，转染慢病毒Lenti-Sfrp1过表达SFRP1，使用3 mmol/L的磷酸二氢钠（Pi）刺激构建细胞血管钙化模型。体内实验采用维生素D3（VD3）构建急性血管钙化模型，腹腔注射SFRP1抑制剂WAY316606（0.5 mg/kg，7 d），Micro-CT检测小鼠主动脉钙化程度。
罗文君, 刘灿昭, 王先宝
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颈总动脉压诱导的小鼠移植静脉血管重构

Zhongshan Daxue xuebao. Yixue kexue ban, 2011
【目的】 研究血压升高引起血管重构的机制【方法】 手术取出麻醉后的11 ~ 12周供体C57BL/6J小鼠的下腔静脉，连接到同窝出生的受体小鼠颈总动脉，构建“静脉桥”继而,收获受颈总动脉压作用不同时间(0,2,4,8周)后的移植静脉,经石蜡包埋HE染色丽春红-维多利亚蓝染色以及平滑肌特异性抗体免疫组化染色后观察其血管构筑【结果】术后各时间点均可见移植静脉血管壁增厚及新生内膜的形成,呈时间依赖性与正常静脉[(11.10 ± 0.9)μm)]相比,术后8周血管壁[(88.97 ± 16)μm)]增厚了8倍 ...
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[Rosa laevigata Michx. inhibits pulmonary arterial smooth muscle cell proliferation in hypertension by modulating the Src-AKT1 axis]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Yang Z, Lü C, Dong Z, Ji S, Bi S, Zhang X, Wang X.   +6 more
europepmc   +1 more source

[Silencing DDX17 inhibits proliferation and migration of pulmonary arterial smooth muscle cells <i>in vitro</i> by decreasing mTORC1 activity]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Deng X, Wang J, Xiong M, Wang T, Yang Y, Li, Sun X.   +6 more
europepmc   +1 more source

[Research progress on calcification mechanism and anti-calcification strategies of vascular grafts]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Su X, Qiu F, Wang H, Han Q.
europepmc   +1 more source

[Efficacy and safety of inhaled salbutamol sulfate combined with beclomethasone dipropionate in children with bronchial asthma: a randomized controlled study]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Chen CZ, Yang Q.
europepmc   +1 more source

[Extracellular matrix materials and tissue regeneration and repair]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Zhao L, Xie H.
europepmc   +1 more source

[Clinical study on repair of oral and perioral tissue defects with facial artery perforator myomucosal flap in 8 cases]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Yi L, Li Z.
europepmc   +1 more source

[1 case of recurrent nasal vestibular aggressive angiomyxoma]. [PDF]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Wang Y, Ai J, Zhao J, Kang Y, Guo S, Wang J.   +5 more
europepmc   +1 more source

CTLA-4Ig融合蛋白对ApoE基因缺陷小鼠动脉粥样 硬化的抑制作用

Zhongshan Daxue xuebao. Yixue kexue ban, 2009
【目的】 探讨CTLA-4Ig融合蛋白对高脂饮食饲养的载脂蛋白E基因缺陷小鼠(ApoE-/-)动脉粥样硬化病变的抑制作用65377;【方法】 25只10周龄ApoE-/-小鼠,高脂饮食饲养4周后,随机取5只验证AS病变(对照组);剩余20只随机分为4组(每组5只),继续高脂饮食饲养,分别采用CTLA-4Ig65380;PBS65380;IgG1腹腔注射,第4组不予处理;8周后取小鼠主动脉进行病理学检查,检测AS相关指标,包括斑块面积/管腔面积比65380;血管内膜/中膜厚度比,斑块内脂质65380 ...
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