Results 1 to 10 of about 1,482,996 (134)
柚皮素通过诱导血红素加氧酶-1的表达抑制氧化应激和血管钙化 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的研究柚皮素对血管钙化发生的作用及氧化应激机制。方法采用不同浓度的柚皮素（5、 10、 20 μmol/L）处理大鼠血管平滑肌细胞和血管环，研究柚皮素对高磷高钙诱导的血管平滑肌细胞和血管环钙化程度的影响。用茜素红染色法测定细胞和血管环钙化的程度，荧光探针DHE检测活性氧（ROS）水平，qPCR和western blot检测血红素加氧酶-1（HO-1）的表达水平。采用HO-1抑制剂ZnPP9处理血管平滑肌细胞，研究抑制HO-1对平滑肌细胞钙化的影响 ...
周芹, 宋艳, 李金河, 梁青春
doaj +2 more sources
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 【目的】研究附子多糖是否抑制血管平滑肌细胞钙化及探讨其机制是否与神经酰胺有关。【方法】我们采用氧化型低密度脂蛋白（Ox-LDL）诱导人体血管平滑肌细胞钙化，用不同浓度的附子多糖处理细胞，茜素红染色测细胞钙化，qRT-PCR检测成骨样分化标志物Msx2、Osterix、BMP2及收缩蛋白SMA的mRNA表达水平，Western blot检测Msx2、BMP2的蛋白表达水平，TUNEL法测细胞凋亡。此外，观察附子多糖对血管平滑肌细胞神经酰胺的水平及其代谢酶中性鞘磷脂酶（N-SMase）的活性的影响。【结果 ...
陈燕亭, 陆立鹤
doaj +1 more source
Linchuang shenzangbing zazhi, 2019 目的探讨血清胎球蛋白A(Fetuin-A)、C反应蛋白(CRP)及骨保护素(OPG)水平与血液透析患者血管钙化的相关性。方法纳入2017年2月至2018年6月间在新疆医科大学第五附属医院行血液透析患者150例,其中75例出现血管钙化(钙化组),75例未出现血管钙化(未钙化组)。回顾性分析与比较两组临床资料与病理资料,并对其进行Logistic回归与Pearson相关分析。结果 (1)两组患者年龄、收缩压、舒张压、红细胞计数、血红蛋白、总蛋白、三酰甘油、血总固醇、高密度脂蛋白、低密度脂蛋白、尿素氮、血肌酐、
MO Ying, REN Rong, ZHANG Yan
doaj +1 more source
Journal of Diabetes, Volume 15, Issue 11, Page 944-954, November 2023., 2023 Highlights Preclinical data showed that dipeptidyl peptidase‐4 inhibitors (DPP‐4is) may prevent insulin‐induced atherosclerosis. In patients treated with insulin for type 2 diabetes who underwent ≥2 serial coronary computed tomography angiographies(CCTA), a new obstructive coronary artery disease (OCAD) was less developed on the follow‐up CCTA in those
Young Choi +4 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 10, Page 853-865, October 2023., 2023 Highlights Few studies have investigated the association of large‐scale biomarkers and pulse wave velocity (PWV) among diabetic patients. This study investigates the relationships of serum laboratory tests with PWV and explored the associations between PWV and all‐cause mortality among diabetic patients.
Yong‐Qi Liang +9 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 7, Page 545-556, July 2023., 2023 Highlights High stress hyperglycemia ratio (SHR) was associated with elevated systematic inflammation in diabetic inpatients with pneumonia on admission. In the absence of hypoglycemia on admission, SHR was of J‐shaped associations with adverse clinical outcomes in diabetic inpatients with pneumonia of different severity.
Bing Liu, Yu Chen, Liping Yu, Min Zhou
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 8, Page 524-531, August 2022., 2022 Highlights In this ESCAPE‐extension study, cilostazol treatment reduced the incidence of adverse cardiovascular events in patients with type 2 diabetes when compared with aspirin for a 5.2‐year median follow‐up. During the follow‐up period, no adverse events were noted in the cilostazol group that exceeded those in the aspirin group.
Minji Sohn, Eun Ju Chun, Soo Lim
wiley +1 more source
Zhongguo cuzhong zazhi, 2018 目的 比较颅内椎动脉与基底动脉血管钙化在计算机断层扫描血管成像（computed tomography angiography，CTA）上的发生率和分布特点。 方法 连续收集2014年2月-2017年10月在本院住院并行头颈部CTA检查的患者资料，通过综合分析 CTA影像资料，比较血管钙化在颅内椎动脉和基底动脉发生率的差异及其在近、远段发生率的差异。 结果 共收集患者93例，其中男64例，女29例，平均年龄（62.8±12.9）岁。血管钙化组的平均年龄 （68.8±10.4）岁，明显高于无血管钙化组的 ...
刘奇，朱先进，赵志强，赵宇，金旻，刘洋，杜彬
doaj +1 more source
维持性血液透析患者血清OPN和iPTH水平与血管钙化的相关性研究
Zhongguo shiyan zhenduanxue, 2021 心血管并发症是维持性血液透析(MHD)患者首要的死亡原因,其血管相关性研究已经成为热点[1-2]。血清骨桥蛋白(OPN)、血清全段甲状旁腺素(iPTH)的变化可能参与了维持性血液透析(MHD)患者的血管钙化发生发展,本研究通过观察血清OPN、iPTH、钙、磷等指标与MHD患者血管钙化程度的关系,旨在探讨MHD患者血管钙化的可能诱发因素,报道如下。
王颜 +8 more
doaj
Integrative Conservation, Volume 4, Issue 4, Page 652-664, December 2025.We profiled nutritional and physiological markers in captive sifakas, endangered primates from Madagascar, managed in expansive, non‐native forest enclosures. Variation in many markers reflects freely foraged diets and the energy required to maintain homeostasis under more naturalistic conditions.
Lydia K. Greene +5 more
wiley +1 more source