海马干细胞来源的外泌体对血管性痴呆大鼠学习记忆能力改善作用及其机制探究 附视频
Zhongguo shiyan zhenduanxue目的 分析海马干细胞来源的外泌体对血管性痴呆大鼠学习记忆能力改善作用及其机制。方法 取新生SD大鼠海马组织，提取海马干细胞外泌体。成年特殊清洁级(SPF)健康雄性SD大鼠90只，随机分为假手术组、模型组及外泌体组，每组30只，检测各组大鼠学习记忆能力、氧化应激因子水平、海马组织病理学变化、海马组织因子、脑微血管密度以及凋亡相关因子变化。结果 透射显微镜观察到海马干细胞来源外泌体结构呈圆形或椭圆形杯状结构的小囊泡，其结构完整，直径50～100 nm之间；特异性标记蛋白CD9、CD63表达阳性 ...
doaj +2 more sources
[Influencing factors of cognitive function decline in elderly patients with type 2 diabetes mellitus]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanZeng H +5 more
europepmc +1 more source
[Development and validation of a risk prediction model for cognitive impairment in rural elderly Chinese populations: evidence from the CHARLS study]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoWang F, Li W, Shang X, Li F.
europepmc +1 more source
[Association of sodium-glucose linked transporter 2 inhibitors with functional outcomes at discharge in diabetic patients with acute ischemic stroke]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanHuang X +8 more
europepmc +1 more source
[Periodontitis and systemic diseases: Thinking and explorations]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanCao P, Luan Q.
europepmc +1 more source
[Aging-Associated Oral Microbiota Dysbiosis and Hypofunction: Their Role in Alzheimer's Disease Pathogenesis]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLi Y, Chen Y, Chen S, Huang X.
europepmc +1 more source
[Effect of 40 Hz pulsed magnetic field on mitochondrial dynamics and heart rate variability in dementia mice]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za ZhiZhang L, Geng D, Xu G, An H.
europepmc +1 more source