Results 31 to 40 of about 20,264 (157)

Photodynamic and antiangiogenic effect of fullerene-cyclodextrin/thalidomide inclusion compound [PDF]

open access: yes, 2016
近年来肿瘤发病率有呈上升的趋势,由于传统治疗方法有风险大、毒副作用强等弊端,人们积极寻找更安全有效的治疗手段。光动力治疗(photodynamictherapy,PDT)具有非侵入性、可多次安全重复使用等优点。抗肿瘤血管生成治疗(antiangiogenictherapy)以肿瘤血管内皮细胞为作用靶点,系统毒性较小,不易产生耐药性,与肿瘤化学药物联用可以起到协同效应。纳米颗粒输送系统基于生物体实体瘤的高通透性和滞留效应(enhancedpermeabilityandretentioneffect,EPR)
周童
core  

Exploring pathophysiological insights to improve diagnostic utility of ultrasound markers for distinguishing placenta accreta spectrum from uterine‐scar dehiscence

open access: yesUltrasound in Obstetrics &Gynecology, Volume 65, Issue 1, Page 85-93, January 2025.
ABSTRACT Objective Accurate differentiation between placenta accreta spectrum (PAS) and uterine‐scar dehiscence with underlying non‐adherent placenta is often challenging, even for PAS experts, both prenatally and intraoperatively. We investigated the use of standardized two‐dimensional grayscale ultrasound and Doppler imaging markers in ...
T. Adu‐Bredu   +3 more
wiley   +1 more source

Roles of Receptor UNC5B in Vascular Development and Tumor Metastasis [PDF]

open access: yes, 2012
血管和神经系统都构成复杂的分支网络,遍布身体的各个区域,并提供信息的双向流动(感觉和运动神经元;动脉和静脉血流)。在体内分布上血管和神经纤维也总是相伴而行到达同一远隔靶位,二者在结构和功能上的相似性,暗示着它们可能受到某些共同信号分子调控。很多神经导向因子都参与了对血管生长发育的调节。UNC5B是首个被证实参与血管发育调控的UNC5受体。但目前对于UNC5B在血管发育中的作用因所使用的动物模型以及UNC5B基因敲除后对表型分析的不同而存在很大的争议,争议的焦点在于UNC5B是促进,还是抑制血管的发育 ...
解宏
core  

响 Impact on the apoptosis, invasion, proliferation ET-1 interfere with the formation of lung cancer [PDF]

open access: yes, 2015
摘要 目的: 肺癌是最常见的恶性肿瘤之一,威胁着全世界人民生命和健康。同时它也是世界上发病率和死亡率增长最快的疾病之一。而且大多数肺癌患者到晚期才被诊断发现,在现阶段肺癌的治疗中,它仍然是无法治愈的。Endothelin(ET),由内皮细胞合成,是一种生物活性肽,是一种强烈的血管收缩剂,具有很强的收缩血管作用,随着对内皮素研究的不断深入,人们发现内皮素与肿瘤关系密切,对肿瘤细胞的生长、增殖、转移、凋亡及化学耐药等都方面都有影响。ET能够产生细胞生长因子可以促进肿瘤DNA合成,基因表达和肿瘤细胞增殖 ...
张振宇
core  

Radiological findings in the proximal sesamoid bones of yearling and 2‐year‐old Thoroughbred sales horses: Prevalence, progression and associations with racing performance

open access: yesEquine Veterinary Journal, Volume 57, Issue 1, Page 87-100, January 2025.
Abstract Background Radiological findings in the proximal sesamoid bones (sesamoids) are a persistent source of controversy at Thoroughbred sales, due to inconsistent classification and conflicting assignment of potential clinical importance. Objectives To define the prevalence of sesamoid findings on sales repository radiographs in yearling and 2‐year‐
Frances J. Peat   +5 more
wiley   +1 more source

Roles of Sema3C on Breast Cancer Angiogenesis and Metastasis [PDF]

open access: yes, 2012
神经系统的发育依赖于一系列导向系统的控制。近年来的研究结果表明,神经导向系统不仅调控神经系统的发育,在血管新生和肿瘤发展等方面也发挥着重要的调控作用。神经生长导向因子Class3semaphorins(Sema3s)是脊椎动物中semaphorin家族中唯一一个的分泌型亚族。在Sema3s家族中的大部分成员在肿瘤发展过程中起抑制作用,而Sema3C却可能是一个促进肿瘤发展的因子。目前对于Sema3C在肿瘤中的作用主要集中在对肿瘤迁移、侵袭的影响等方面,对于肿瘤血管新生的影响还未见报道 ...
叶丽颖
core  

Combined first‐trimester screening and invasive diagnostics for atypical chromosomal aberrations: Danish nationwide study of prenatal profiles and detection compared with NIPT

open access: yesUltrasound in Obstetrics &Gynecology, Volume 64, Issue 4, Page 470-479, October 2024.
ABSTRACT Objectives Our aim was to examine the prenatal profiles of pregnancies affected by an atypical chromosomal aberration, focusing on pathogenic copy‐number variants (pCNVs). We also wanted to quantify the performance of combined first‐trimester screening (cFTS) and a second‐trimester anomaly scan in detecting these aberrations. Finally, we aimed
K. Gadsbøll   +6 more
wiley   +1 more source

Exploring barriers to menstrual education between maternal figures and young girls: A pilot study in South Africa

open access: yesSexuality, Gender &Policy, Volume 7, Issue 3, Page 305-321, August 2024.
Abstract The study sought to explore barriers to menstrual education between maternal figures and young girls. Menstruation is a key part of the reproductive process and affects young adolescent girls. Menstrual blood is perceived as contaminating and impure, leading to the socialization of women and girls undergoing menstruation to feel soiled and ...
Viwe Sobudula, Dhee Naidoo
wiley   +1 more source

卵巢肿块中超声造影参数图像处理软件的DVP表现及与VEGF和HIF-1a同步相关研究

open access: yesZhongguo shiyan zhenduanxue, 2017
对于实质性的肿瘤微环境来说,缺氧状态属于一种非常常见的基本特征[1]。因为恶性肿瘤增殖生长的速度过于迅速,和肿瘤细胞中的血管不成比例,造成局部组织严重缺氧[2]。肿瘤可通过多种方式适应缺氧微环境,其中最重要的代偿机制和肿瘤血管的诱导形成密切关联[3,4]。血管内皮生长因子(Vascular endothelial growth factor,VEGF)属于一种非常重要的生长因子,主要作用是对恶性肿瘤血管的形成产生刺激作用 ...
仲跻凤, 孟庆欣
doaj  

蒙药肉桂对LPS诱导血管内皮细胞损伤的保护性机制的研究进展

open access: yesZhongguo shiyan zhenduanxue, 2021
肉桂(Cinnamon)即是一种香料,也是一种重要的药材,属于传统蒙药里的镇赫依药物,其生物活性在多种生物功能中得到了广泛的研究,包括抗菌、抗氧化、抗炎、抗癌、降血糖、抗心血管疾病等作用[1-2]。血管内皮细胞(VECs)是构成动脉、静脉和毛细血管的单细胞层,在血管腔内的循环血液和血管壁之间形成一道屏障[3]。VECs功能障碍与心血管、脓毒症、糖尿病和血管炎等多种疾病的发病机制有关。脂多糖(LPS)可通过诱导组织细胞释放TNF-α、IL-6等细胞因子,促进血管内皮细胞的黏附以及炎症反应 ...
宋利华, 福泉, 杨航, 包丽丽
doaj  

Home - About - Disclaimer - Privacy