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血管新生抑制因子在糖尿病微血管并发症中的研究及 应用前景

Zhongshan Daxue xuebao. Yixue kexue ban, 2017
糖尿病微血管并发症累及全身各个器官，导致糖尿病患者寿命下降和生活质量降低。血管新生是糖尿病微 血管并发症的基本病理特征，而血管新生抑制因子在血管新生平衡调控和糖尿病微血管并发症发生发展中起了重要作 用。本文就血管新生抑制因子与糖尿病微血管并发症的研究进展及治疗前景作一综述，包括血管新生抑制因子与糖尿病 各种微血管并发症（糖尿病视网膜病变、糖尿病足、糖尿病勃起功能障碍和糖尿病肾病等）等的关系，最后概述了糖尿病微 血管并发症的临床治疗现状与内源性新生血管抑制因子在其中的应用前景。
高国全
doaj   +1 more source

女性2型糖尿病患者血糖控制与骨密度关系的分析 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 2007
【目的】研究女性2型糖尿病患者血糖水平与骨密度的关系。【方法】以73名女性2型糖尿病患者作为研究对象,根据血糖控制情况分为血糖控制良好组32例和血糖控制不佳组41例,采用双能X线骨密度仪测定所有患者腰椎及股骨近端的骨密度,并与年龄和绝经年限相匹配的女性健康对照30例进行比较。【结果】血糖控制良好的糖尿病组和对照组各部位的骨密度值均比血糖控制不佳的糖尿病组高,差别有统计学意义（P〈0.05）。血糖控制良好的糖尿病组和对照组比较,各部位的骨密度值差别无统计学意义（P〉0.05）。【结论 ...
郭颖, 丁鹤林, 傅祖植
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儿童肝糖原贮积病血糖及生化指标的横断面调查 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban
目的肝糖原贮积病（GSD）患者有反复的低血糖发作。本研究的目的是调查分析儿童肝糖原贮积病（GSD）日常血糖及生化指标，为预防低血糖发作和临床管理提供数据支持。方法横断面现场调查研究，收集2024年7月14日在广东省人民医院儿科进行医患交流义诊活动的肝GSD患者及家长的临床资料，现场采集患者及家庭对照者的外周血，检测和分析两组间血糖及生化指标的差异。结果44例肝GSD患者中男34例，女10例。亚型包括GSD Ib型14例、Ia型15例，Ⅲ型2例，Ⅵ型7例，Ⅸ型6例。年龄为7.60（5.08~11.98）岁，
马妮, 吴昊天, 王颖, 杨静, 梁丹霞, 杨敏   +5 more
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纯母乳喂养新生儿低血糖影响因素研究 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 2000
【目的】探讨纯母乳喂养新生儿血糖变化及低血糖的影响因素。【方法】在出生后1、4、8、12 、24、48 、72 h 对纯母 乳喂养的新生儿306 例进行血糖系列监测。【结果】新生儿出生后1 h 的平均血糖浓度较低为(2.8±0.95)mmol/ L, 4 h 后升 高并逐渐稳定为(3.22±1.03)mmol/ L;有糖代谢异常母亲的新生儿、巨大儿、低体重儿, 其出生3 天内低血糖的发生率分别 为22.4 %(11/49)、36.9%(31/ 84)、29.6 %(8/27 ...
谢红宁, 谭丽君, 陈筠虹, 詹前胜, 房小玲   +4 more
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Rationale and design for the Blood Pressure Control Target in Diabetes (BPROAD) study 糖尿病血压控制目标(BPROAD)研究的原理和设计

Journal of Diabetes, Volume 15, Issue 12, Page 1029-1040, December 2023., 2023
Highlights The Blood Pressure Control Target in Diabetes (BPROAD) study is a multicenter, randomized controlled trial conducted in mainland China to test the hypothesis of whether intensive blood pressure (BP) management (systolic BP <120 mm Hg) has additional benefits over standard BP management (systolic BP <140 mm Hg) over a follow‐up period of up ...
The BPROAD Study Group, Guang Ning, Jiang He, Weiqing Wang, Yufang Bi, Dalong Zhu, Jiguang Wang, Shengdi Chen, Yu Xu, BPROAD coordinating team at Ruijin Hospital, Lawrence J. Appel, William C. Cushman, Vivian A. Fonseca, Jeff D. Williamson, David M. Reboussin, Yaling Han, Hongbing Shen, Minghui Zhao, Hui Wang   +18 more
wiley   +1 more source

胰高血糖素放射免疫分析研究

Zhongshan Daxue xuebao. Yixue kexue ban, 1984
胰高血糖素为一单键肽,含29个氨基酸残基,分子量为3485,主要由胰岛A细胞分泌。胰高血糖索的生理作用广泛,它与胰岛B细胞分泌的胰岛素互相调节,为维持体内血糖稳定主要因素之一。血浆胰高血糖素含量的测定,对糖尿病发病机理及其他多种疾病的研究,均有重要的意义。胰高血糖素分子量较小,抗原性较弱,且与肠胰高血糖素的分子结构部分相同。要获得高效价、高亲和力和高特异性的抗体,以及制备免疫活性和稳定性良好、放比强度符合要求的标记抗原并不容易,因而建立胰高血糖素放射免疫分析,有较多的困难。国内迄今未有成功的报道 ...
吕植
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Blood pressure targets for prevention of cognitive decline in patients with diabetes and hypertension: Design of the Blood Pressure Control Target in Diabetes (BPROAD) Cognitive Study 高血压目标对于预防糖尿病和高血压患者的认知下降:BPROAD认知研究的设计

Journal of Diabetes, Volume 15, Issue 12, Page 1041-1047, December 2023., 2023
Highlights The optimal blood pressure (BP) target in patients with type 2 diabetes mellitus (T2DM) for the management of cognitive decline remains unknown. The Blood Pressure Control Target in Diabetes (BPROAD) Cognitive Study was designed to determine whether intensive BP treatment (systolic BP <120 mm Hg) reduces risk of dementia and mild cognitive ...
The BPROAD Study Group, Guang Ning, Jiang He, Weiqing Wang, Yufang Bi, Dalong Zhu, Jiguang Wang, Shengdi Chen, Yu Xu, BPROAD coordinating team at Ruijin Hospital, Lawrence J. Appel, William C. Cushman, Vivian A. Fonseca, Jeff D. Williamson, David M. Reboussin, Yaling Han, Hongbing Shen, Minghui Zhao, Hui Wang   +18 more
wiley   +1 more source

Patient experiences of continuous glucose monitoring and sensor‐augmented insulin pump therapy for diabetes: A systematic review of qualitative studies 糖尿病患者接受连续血糖监测和传感器增强胰岛素泵治疗的体验:对定性研究的系统综述

Journal of Diabetes, Volume 15, Issue 12, Page 1048-1069, December 2023., 2023
Highlights We identified that CGM can increase motivation for self‐management and confidence in treatments. A supportive treating team may help to reduce the practical and psychological burden in patients with type 1 and type 2 diabetes. Abstract Aims Blood glucose control is central to the management of diabetes, and continuous glucose monitoring (CGM)
Patrizia Natale, Sharon Chen, Clara K. Chow, Ngai Wah Cheung, David Martinez‐Martin, Corinne Caillaud, Nicole Scholes‐Robertson, Ayano Kelly, Jonathan C. Craig, Giovanni Strippoli, Allison Jaure   +10 more
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Decreased in n‐3 DHA enriched triacylglycerol in small extracellular vesicles of diabetic patients with cardiac dysfunction 糖尿病合并心脏功能障碍患者细胞外小囊泡中n‐3 DHA 富集的三酰甘油减少

Journal of Diabetes, Volume 15, Issue 12, Page 1070-1080, December 2023., 2023
Highlights Lipid profiles of small extracellular vesicles (sEVs) in patients with diabetes or diabetic cardiovascular disease are rarely reported. n‐3 docosahexaenoic acid (DHA)‐enriched triacylglycerol (TG) was found to decrease in sEVs from serum of patients with diabetic cardiovascular disease (DM‐CAD).
Wei Ding, Xuejuan Zhang, Dandan Xiao, Wenguang Chang   +3 more
wiley   +1 more source

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
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