Results 91 to 100 of about 69,546 (177)

Expression and Significance of gp96 and Immune-related Gene CTLA-4, CD8 in Lung Cancer Tissues [PDF]

open access: yes, 2010
Background and objective It has been proven that gp96 plays an important role in specific cytotoxic immune response which is involved in anti-tumor effect in the body.
Haiyan ZHENG   +4 more
core  

Coalitions and Characters: Tracing the Maturity of Sweden's Preventing and Countering Violent Extremism Policies

open access: yesReview of Policy Research, Volume 43, Issue 2, March 2026.
ABSTRACT We trace the shift from a nascent to a mature policy subsystem by examining a hitherto overlooked aspect in policy process scholarship: the relationship between advocacy coalition beliefs and the narratives they express over time. The empirical focus of this case study is Sweden's Preventing and Countering Violent Extremism (P/CVE) policies ...
Simone Grännsjö   +3 more
wiley   +1 more source

人脐血T/NK 细胞KIR 分子表达的初步探讨

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2002
【目的】探讨脐血中T 淋巴细胞和自然杀伤(NK)细胞上杀伤性抑制性受体(KIR)的表达特性。【方法】采用流 式细胞仪检测26 份正常分娩新生儿脐血的T/ NK 细胞表面KIR 分子表达(CD158a , CD158b 和CD94), 并与正常外周血比较。 【结果】脐血中T 淋巴细胞和NK 细胞均存在KIR 分子表达;脐血和外周血中T 淋巴细胞CD158 分子表达低于NK 细胞(P
陈 纯, 黄绍良, 魏 菁
doaj  

Analysis of Dvl function and expression patterns of Wnt/β-catenin signaling genes in amphioxus [PDF]

open access: yes, 2015
Wnt/β-catenin信号通路是后生动物中一条相对保守的信号通路,广泛参与早期胚胎体轴的建立以及多种器官的形态建成与分化。该信号通路在很多物种中都已有研究,但是在脊索动物文昌鱼中该信号通路的研究才刚刚开始,研究的内容仅包括Wnts、β-catenin、Tcf、Axin、Dkks和sFRPs基因的表达谱分析以及化学试剂处理对胚胎发育的影响,在文昌鱼中关于该信号通路中很多重要基因的功能研究尚未开始。 本文鉴定和克隆了文昌鱼Wnt/β-catenin信号通路中的Dvl(Dishevelled)基因 ...
王净
core  

Immigration, Beneficiary Assumptions, and Welfare Support

open access: yesReview of Policy Research, Volume 43, Issue 2, March 2026.
ABSTRACT Previous research demonstrates that assumptions and perceptions about who benefits from welfare programs and the deservingness of those welfare beneficiaries play a considerable role in shaping individuals' welfare attitudes. However, a holistic understanding of how these assumptions and perceptions are formed remains limited. In this study, I
Hang Qi
wiley   +1 more source

拓扑异构酶2α受抑癌基因p53的调控并调节前列腺癌细胞的增殖能力

open access: yesZhongguo shiyan zhenduanxue, 2017
目的观察TOP2α对前列腺癌细胞增殖能力的影响以及抑癌基因p53对TOP2α的调控能力。方法以Lipofectamine2000试剂转染针对p53和非特异性对照组的siRNA,干扰前列腺癌细胞C4-2中p53的表达,采用Realtime PCR和Western Blot检测细胞内TOP2α的mRNA和蛋白水平表达变化;采用质粒转染法在293T细胞中过表达p53后检测TOP2α蛋白水平的变化,明确p53对TOP2α表达的影响 ...
梁婷婷, 王永坤, 王尧
doaj  

Study on the effects of down-regulating Annexin A3 expression on biological behaviors of lung adenocarcinoma and its molecular mechanism [PDF]

open access: yes, 2015
肺癌是我国第一大癌症,其发病率和死亡率均居恶性肿瘤之首,严重危害人类健康。肺癌按组织学类型可分为鳞癌、腺癌、小细胞癌和大细胞癌。近年来,肺腺癌(lungadenocarcinoma,AdC)的发病率呈逐步上升趋势,且患者死亡率高、预后极差。癌细胞易转移是肺腺癌患者预后差的主要原因,因此,探寻肺腺癌转移的分子机制及其新的治疗靶标,对于提高肺腺癌患者预后意义重大。我们前期研究中,采用定量蛋白质组学技术鉴定出AnnexinA3(Anxa3)为一个新的肺腺癌转移相关分子 ...
刘青青
core  

大肠癌原发灶及粪便标本中基因mRNA表达及其临床意义

open access: yesZhongguo shiyan zhenduanxue, 2012
目的通过对COX-2,CK-20,CD44v6mRNA在结直肠原发灶及病人粪便中的表达,证实粪便中COX-2,CK-20,CD44v6mRNA表达来源于原发灶肿瘤细胞的脱落所致,为临床结直肠癌筛查选择合适的多基因标记物联合检测指标。方法对38例行结肠癌根治术的病人,原发灶及术前收集的粪便标本采用RT-PCR技术对COX-2,CK-20,CD44v6mRNA表达进行检查。结果研究发现,COX-2mRNA在原发灶及粪便中同时阳性表达率为44.7%(17/38),同时阴性表达率为39.5%(15/38 ...
赵金伟   +4 more
doaj  

Abnormal lipid metabolism in pterygium [PDF]

open access: yes, 2015
研究背景:翼状胬肉作为一种常见的眼科疾病,其发病机理尚未明确,目前缺乏有效的药物治疗方法,手术切除是唯一有效的治疗方式。深入研究翼状胬肉的病理改变将有助于揭示翼状胬肉的病理生理过程,为发展新的治疗方法奠定基础。近年来,有研究发现翼状胬肉组织中存在异常脂类代谢,但是异常脂类代谢在翼状胬肉发生发展中的作用仍不清楚。 实验目的:检测翼状胬肉组织中的异常脂类代谢,探究脂类代谢异常在翼状胬肉发生发展过程中的作用。 实验方法:本实验收集35例翼状胬肉患者的病理组织和5例患者的正常结膜组织,用于冰冻包埋 ...
邹笃雷
core  

两种载体表达人乳头瘤病毒6型L1基因的比较

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 1991
以表达融合蛋白的载体PUR288以及高效表达载体PBV221作载体,在大肠杆菌内成功地表达了我国克隆的HPV6BVL_I基因,并对表达蛋白进行免疫学鉴定,对两种载体的表达情况进行了讨论。
doaj  

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