Results 81 to 90 of about 70,351 (171)
Zhongguo shiyan zhenduanxue, 2010 目的探讨临床创面组织中生长相关因子c-sis和c-jun的表达变化规律。方法应用免疫组化方法对临床16例烧伤病人创面愈合过程中c-sis和c-jun表达变化进行检测,计算阳性表达细胞数。结果临床创面愈合中c-sis和c-jun有明显的规律性的表达。但二者表达模式不尽相同。c-sis在伤后5天表达量增加,10天达峰值,其阳性颗粒主要分布于真皮层成纤维细胞的胞核中。c-jun的表达在伤后1天达最高值,其阳性颗粒主要分布于表皮基底细胞胞浆及真皮成纤维细胞的胞核内。结论烧伤可以诱导皮肤创面组织原癌基因c ...
隋志甫 +4 more
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The Expression and Biological Significance of PD-L1 on Lung Cancer Cell Lines [PDF]
, 2009 Background and objective Tumor-associated PD-L1 expression was recently shown to promote T-cell apoptosis and proposed as a potential mechanism of immune evasion by tumors. On the basis of the ability of tumor-associated PD-L1 to mediate activated T-cell
Cheng CHEN +6 more
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Zhongguo shiyan zhenduanxue, 2013 目的检测乳腺癌组织中Her-2/neu和CD138的表达情况,探讨二者在乳腺癌中表达的意义和相互关系。方法应用免疫组化方法（S-P法）观察102例乳腺癌,30例乳腺良性病变组织（15例乳腺良性肿瘤与15例正常乳腺组织）Her-2/neu和CD138的表达。结果①102例乳腺癌组织和30例乳腺良性病变组织中Her-2/neu阳性表达率分别为58%和0%,CD138阳性表达率分别为41%-42%和100%。乳腺癌组织中Her-2/neu阳性表达率显著高于其在良性病变组织的阳性表达率 ...
陈军, 胡永均, 张桃华, 陈玲玲
doaj
Detection of MTAP Protein and Gene Expression in Non-small Cell Lung Cancer [PDF]
, 2011 Background and objective The abnormal expression of MTAP, a tumor suppressor gene, is found in a variety of tumor tissues. The aim of this study is to detect the expression of MTAP mRNA protein and the clinical significance for the therapy of non-small ...
Baoqing DING +3 more
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拓扑异构酶2α受抑癌基因p53的调控并调节前列腺癌细胞的增殖能力
Zhongguo shiyan zhenduanxue, 2017 目的观察TOP2α对前列腺癌细胞增殖能力的影响以及抑癌基因p53对TOP2α的调控能力。方法以Lipofectamine2000试剂转染针对p53和非特异性对照组的siRNA,干扰前列腺癌细胞C4-2中p53的表达,采用Realtime PCR和Western Blot检测细胞内TOP2α的mRNA和蛋白水平表达变化;采用质粒转染法在293T细胞中过表达p53后检测TOP2α蛋白水平的变化,明确p53对TOP2α表达的影响 ...
梁婷婷, 王永坤, 王尧
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Clinicopathological Research and Expression of PTEN/PI3K/Akt Signaling Pathway in Non-small Cell Lung Cancer [PDF]
, 2009 Background and objective It has been known that abnormality of PTEN/PI3K/Akt signal pathway played an important role in initiation of some malignant tumors.
Can XU +3 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】探讨脐血中T 淋巴细胞和自然杀伤(NK)细胞上杀伤性抑制性受体(KIR)的表达特性。【方法】采用流 式细胞仪检测26 份正常分娩新生儿脐血的T/ NK 细胞表面KIR 分子表达(CD158a , CD158b 和CD94), 并与正常外周血比较。 【结果】脐血中T 淋巴细胞和NK 细胞均存在KIR 分子表达;脐血和外周血中T 淋巴细胞CD158 分子表达低于NK 细胞(P
陈 纯, 黄绍良, 魏 菁
doaj
Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/-catenin Signaling [PDF]
, 2016 SRC-1（Steroidreceptorcoactivator1）不仅是雄激素受体（androgenreceptor，AR）和雌激素受体（estrogenreceptor，ER)等激素受体的转录辅激活因子，而且能辅激活许多转录因子。SRC-1在乳腺癌和前列腺癌的发生发展进程中起着重要的作用，但是人们对于它在肝癌发生发展进程中所起的作用仍不清楚。在本文中，我们报道了SRC-1在62.5%（25/40）的肝癌组织样本（humanhepatocellularcarcinoma，HCC）中过表达。敲低SRC ...
童章炜
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Zhongguo shiyan zhenduanxue, 2016 目的探讨IKKɑ调控表皮角朊细胞的增殖和分化及与p63的关系。方法原代分离培养野生型（wildtype,WT）和Ikkɑ基因敲除小鼠（Ikkα-/-）的表皮角朊细胞（WT-KTC及Ikkα-/-KTC）,Western blot检测Ikkα-/-中p63的表达。含0.5mM Ca2+培养基刺激分化后,免疫荧光染色观察分化标记物Zonula occludens-1（ZO-1）及增殖标记物BrdU的表达。制备沉默p63表达的慢病毒并感染Ikkα-/-KTC,观察其增殖及分化能力的变化。结果在正常培养条件下 ...
沈燕君 +4 more
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Correlations between IGF-IR Expression and Clinicopathological Factors and Prognosis in Patients with Lung Adenocarcinoma [PDF]
, 2010 Background and objective The incidence of lung adenocarcinoma increases rapidly, and IGF-IR is the key mediator of several growth factors signal transduction, therefore it plays an important role in the proliferation and differentiation of cancer cell ...
Baohui HAN +4 more
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