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外源性硫化氢通过PI3K/Akt/eNOS通路改善过氧化氢诱导的人脐静脉内皮细胞衰老 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 2021
目的本研究拟探讨磷脂酰肌醇3激酶/蛋白激酶B/内皮型一氧化氮合酶（PI3K /Akt /eNOS）通路对硫化氢（H2S）改善内皮细胞衰老的作用。方法建立60 μmol/L过氧化氢（H2O2）诱导的人脐静脉内皮细胞（HUVEC）衰老模型；衰老模型的评估及不同浓度硫氢化钠（NaHS）预处理对衰老的作用均通过检测纤溶酶原激活物抑制剂1（PAI-1）的表达水平和衰老相关β-半乳糖苷酶（SA-β-Gal）染色阳性率来研究评估。同时通过Western blot法检测各组内皮细胞中蛋白激酶B（Akt）蛋白 ...
牛海名, 李建伟, 陈妙莲, 刘定辉, 吴琳, 凌叶盛, 余显冠, 钱孝贤   +7 more
doaj   +3 more sources

海马神经元和神经递质的衰老性变化及自由基分析——探讨老年性记忆减退的神经基础 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 1988
用形态计量、显微光学测定,放射自显影和ESR分析等方法研究揭示,衰老时海马神经元的RNA、核仁体积、衰老色素(LP)和谷氨酸(Glu)递质等发生了明显的改变;海马自由基含量显著高于其他脑区。本文就自由基损害与海马衰老的易感性,神经元损害间的联系及其与老年性记忆减退的关系进行了讨论。
姚志彬
doaj   +2 more sources

Neighborhood disadvantage is associated with biological aging: Intervention‐induced enhancement of couple functioning confers resilience

Family Process, Volume 62, Issue 2, Page 818-834, June 2023., 2023
Abstract The accelerated pace of biological aging predicts mortality and morbidity later in life. The current study examines whether a change in supportive couple functioning buffers accelerated aging associated with stressful community environments among Black Americans who live in rural, Southern, disadvantaged neighborhoods.
Man‐Kit Lei, Steven R. H. Beach
wiley   +1 more source

Autophagy in the retinal neurovascular unit: New perspectives into diabetic retinopathy 视网膜神经血管单元自噬:糖尿病视网膜病变的新视角

Journal of Diabetes, Volume 15, Issue 5, Page 382-396, May 2023., 2023
HighlightsAutophagy is closely related to retinal neurovascular units in diabetes retinopathy. Different cells participate in the occurrence and development of diseases through autophagy, and targeted autophagy may be a new direction of treatment in the future. Emphasized the close relationship between diabetic retinopathy (DR) and autophagy Summarized
Xiongyi Yang, Zexin Huang, Mei Xu, Yanxia Chen, Mingzhe Cao, Guoguo Yi, Min Fu   +6 more
wiley   +1 more source

Longer leukocyte telomere length increases cardiovascular mortality in type 2 diabetes patients 白细胞端粒长度增长会增加2型糖尿病患者的心血管死亡率

Journal of Diabetes, Volume 15, Issue 4, Page 325-331, April 2023., 2023
Highlights Leukocyte telomere length was independently associated with the risk of cardiovascular mortality. Leukocyte telomere length was not associated with the risk of all‐cause mortality in patients with diabetes. Telomere length may be a predictor of cardiovascular mortality in diabetes.
Ziwei Chen, Yao Shen, Jing He, Yang Shen, Weida Zhu, Xiaohui Wu, Mingbing Xiao   +6 more
wiley   +1 more source

The Association of Retinal age gap with metabolic syndrome and inflammation 视网膜年龄差与代谢综合征和炎症的关系

Journal of Diabetes, Volume 15, Issue 3, Page 237-245, March 2023., 2023
Highlights Retinal age gap is a non‐invasive and cost‐effective aging biomarker. Retinal age gap was significantly associated with metabolic syndrome and inflammation. Retinal age gap could be potentially used as a screening tool for metabolic syndrome in large populations.
Zhuoting Zhu, Dan Liu, Ruiye Chen, Wenyi Hu, Huan Liao, Katerina Kiburg, Jason Ha, Shuang He, Xianwen Shang, Yu Huang, Wei Wang, Honghua Yu, Xiaohong Yang, Mingguang He   +13 more
wiley   +1 more source

Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease 2型糖尿病患者表皮功能的变化及其对治疗的意义

Journal of Diabetes, Volume 14, Issue 9, Page 586-595, September 2022., 2022
Highlights Individuals with type 2 diabetes display epidermal dysfunction. Epidermal dysfunction can provoke cutaneous and extracutaneous inflammation. Because of the pathogenic role of inflammation in type 2 diabetes, improvements in epidermal functions could benefit type 2 diabetes.
Mao‐Qiang Man, Joan S. Wakefield, Theodora M. Mauro, Peter M. Elias   +3 more
wiley   +1 more source

Werner syndrome presenting as early‐onset diabetes: A case report

Journal of Diabetes Investigation, Volume 13, Issue 3, Page 592-598, March 2022., 2022
We report a Chinese patient with Werner syndrome with uncommon early‐onset diabetes at age 18 years, who had low body mass index, insulin resistance, negative antibodies of diabetes and early onset of cataracts. Genome sequencing and reverse transcription polymerase chain reaction confirm the diagnosis.
Xiaoli Wang, Siruo Liu, Fengye Qin, Qian Liu, Qiuyue Wang   +4 more
wiley   +1 more source

Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells 2型糖尿病、细胞功能障碍和氧化还原信号的关系:人胰腺α‐和β‐细胞单细胞基因表达的meta分析

Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022
Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques, Emily Formato, Wenle Liang, Emily Leonard, Alicia R. Timme‐Laragy   +4 more
wiley   +1 more source

Can defined contribution pensions survive the pandemic? The Chilean case

International Social Security Review, Volume 75, Issue 1, Page 31-50, January/March 2022., 2022
Abstract The impact of the COVID‐19 pandemic threatens the viability of Chile’s defined contribution (DC) pension system, undermining its financial foundation and exposing its vulnerability to political risk. The COVID‐19 crisis led to the approval of three rounds of emergency withdrawals of 10 per cent of pension savings (as of April 2021).
Stephen J. Kay, Silvia Borzutzky
wiley   +1 more source