Results 1 to 10 of about 1,784 (148)
外源性硫化氢通过PI3K/Akt/eNOS通路改善过氧化氢诱导的人脐静脉内皮细胞衰老 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的本研究拟探讨磷脂酰肌醇3激酶/蛋白激酶B/内皮型一氧化氮合酶（PI3K /Akt /eNOS）通路对硫化氢（H2S）改善内皮细胞衰老的作用。方法建立60 μmol/L过氧化氢（H2O2）诱导的人脐静脉内皮细胞（HUVEC）衰老模型；衰老模型的评估及不同浓度硫氢化钠（NaHS）预处理对衰老的作用均通过检测纤溶酶原激活物抑制剂1（PAI-1）的表达水平和衰老相关β-半乳糖苷酶（SA-β-Gal）染色阳性率来研究评估。同时通过Western blot法检测各组内皮细胞中蛋白激酶B（Akt）蛋白 ...
牛海名 +7 more
doaj +3 more sources
浙江大学学报. 医学版病毒诱导的衰老（VIS）是一种重要的生物学现象，对机体产生多方面影响，包括免疫系统功能下降、衰老相关疾病的发生发展以及机体的加速老化。多种常见RNA病毒（严重急性呼吸综合征冠状病毒2型）、DNA病毒（疱疹病毒、乙型肝炎病毒等）以及蛋白质病毒（朊病毒）均能诱导宿主细胞发生VIS，主要涉及cGAS-STING信号通路的异常激活及DNA损伤应答等机制，也可能与细胞内相分离引起的整合应激反应相关。研究发现，病毒感染与细胞衰老之间的作用是相互的。细胞衰老是宿主细胞限制病毒复制和传播的一种防御机制 ...
常 允闯 +4 more
doaj +2 more sources
Journal of Diabetes, 2022 Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation and pollution, and epidermal function itself can regulate cutaneous and extracutaneous ...
Mao‐Qiang Man +3 more
doaj +2 more sources
浙江大学学报. 医学版肝疾病中的炎症衰老作用机制和干预措施是当前研究的热点。炎症衰老是一种与慢性炎症相关的细胞功能衰退过程，广泛参与肝疾病的发生发展。对于病毒性肝炎，炎症衰老的机制主要涉及氧化应激、细胞凋亡和坏死以及肠道菌群失调。非酒精性脂肪性肝病中的炎症衰老机制较为复杂，涉及胰岛素抵抗和脂肪沉积、脂质代谢紊乱、肠道菌群失调以及NAD+代谢异常。肝脏肿瘤中的炎症衰老则表现为肿瘤抑制机制的减弱、肝脏微环境的重塑、代谢重编程以及免疫逃逸机制的强化。目前，针对炎症衰老的治疗策略正在逐步发展，抗氧化治疗 ...
徐 燕萍 +3 more
doaj +2 more sources
韭菜子等补肾中药促进雷帕霉素诱导的急性退化胸腺再生 [PDF]
浙江大学学报. 医学版目的：探讨以韭菜子为代表的多种补肾中药对小鼠胸腺急性退化后再生过程的影响。方法：8周龄BALB/c雄性小鼠48只，随机分为正常对照组、模型对照组、阴性对照组、阳性对照组、蛇床子组、补骨脂组、覆盆子组和韭菜子组，每组6只。除正常对照组外，各组小鼠接受雷帕霉素（1 mg·kg－1·d－1）连续腹腔注射5 d并饥饿处理14 h诱导胸腺急性退化。造模成功后，阴性对照组腹腔注射等量等渗氯化钠溶液，阳性对照组腹腔注射二甲双胍（300 mg·kg－1·d－1），其他各组分别灌胃给予蛇床子（0.78 g·kg－1·d ...
温 许诺 +4 more
doaj +2 more sources
Journal of Diabetes, Volume 15, Issue 5, Page 382-396, May 2023., 2023 HighlightsAutophagy is closely related to retinal neurovascular units in diabetes retinopathy. Different cells participate in the occurrence and development of diseases through autophagy, and targeted autophagy may be a new direction of treatment in the future. Emphasized the close relationship between diabetic retinopathy (DR) and autophagy Summarized
Xiongyi Yang +6 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 4, Page 325-331, April 2023., 2023 Highlights Leukocyte telomere length was independently associated with the risk of cardiovascular mortality. Leukocyte telomere length was not associated with the risk of all‐cause mortality in patients with diabetes. Telomere length may be a predictor of cardiovascular mortality in diabetes.
Ziwei Chen +6 more
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022 Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques +4 more
wiley +1 more source
RBX1 regulates uveal melanoma immune-related genes via STAT1 [PDF]
, 2023 Objective·To investigate the role of RBX1 (ring-box protein 1) in the regulation of immune-related genes in uveal melanoma (UVM) tumor cells.Methods·The Cancer Genome Atlas (TCGA) was searched to analyze the expression levels of RBX1 in tumors and the ...
FAN Xianqun +4 more
core +1 more source
The latest research progress on P53 and tumor metabolism [PDF]
, 2023 P53 is a key factor encoded by the TP53, and it prevents cells from becoming cancerous and has a wide range of powerful functions. p53 is found to play an important role in inducing DNA repair, apoptosis, cell cycle arrest and senescence, and the loss of
ZHAI Haihui, LIU Yuanqi, ZHANG Congzheng, GUAN Liping, HAN Tao
core +1 more source