Protective effects of the salt-induced kinase inhibitor HG-9-91-01 on sepsis-associated cognitive dysfunction in mice and the underlying mechanisms. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Wang X, Wang S, Cui Y.
europepmc +1 more source
[Spatial distribution of cognitive dysfunction and its risk factors in Chinese population aged 45 years and above]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 He S, Zhang J, Yang R, Yuan P.
europepmc +1 more source
The role of appoptosin in apoptosin-promoting and Parkinson's Disease [PDF]
, 2015 摘要 帕金森氏病（Parkinson’sDisease，PD）是一种中老年人常见的慢性进行性神经系统退行性疾病，其主要病理变化是黑质致密部多巴胺能神经元进行性死亡、残存神经元多巴胺合成能力降低，从而导致锥体外系运动调节功能减弱。目前关于帕金森氏病的发病机制研究涉及到遗传易感、环境毒素、老化、凋亡等很多方面，其中Ⅱ型囊泡单胺转运体（VMAT2）在储存传递单胺类神经递质、清除神经毒性物质入囊泡等方面的功能在帕金森氏病发病机制中起到了关键的作用。Appoptosin，又名SLC25A38，是一个与APP ...
李远方
core
Research progress on the effects and mechanisms of tonifying traditional Chinese medicine ingredients in the treatment of Alzheimer's disease over the past five years [PDF]
With the intensification of population aging, the number of patients with Alzheimer's disease (AD) continues to rise. However, the exact pathogenesis of AD remains unclear, and existing drugs can only alleviate symptoms without providing a cure ...
GUO Hongwei +4 more
core +1 more source
Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Dong X, Sun H, Mao J, Zhang S, Meng C.
europepmc +1 more source
Cuta deficiency causes memory impairments in middle-aged mice [PDF]
, 2016 阿尔茨海默症（AD）发病机制的核心是具有神经毒性的淀粉样蛋白（Aβ）在大脑中的过度堆积。Aβ是由淀粉样蛋白前体蛋白（APP）经过β-分泌酶（β-secretase或BACE1）和γ-分泌酶（γ-secretase）的顺序切割加工而成。CUTA是CutA二价阳离子耐受蛋白，参与调控乙酰胆碱酯酶在细胞内的聚合和转运。本实验室的前期研究发现CUTA和BACE1相互作用，并调节BACE1在细胞中的定位以及Aβ的生成。为了在体内研究CUTA的作用，本实验室构建了Cuta基因敲除的小鼠模型 ...
石准
core
The correlation of serum s⁃100β，TPO⁃Ab and Hcy levels with cognitive function in patients with schizophrenia [PDF]
"Objective To explore the predictive value of serum astrocyte⁃derived protein s⁃100β，thyroid peroxidase antibody（TPO⁃Ab）and homocysteine（Hcy）levels for cognitive impairment in patients with schizophrenia.
LI Lijuan*，TIAN Baitong，SUN Yu，ZHANG Enlong，XU Defeng，WANG Linping
core +2 more sources
Multimorbidity status and risk factors among adults aged 45-64 years in 15 provinces of China in 2018: Based on association rule analysis [PDF]
BackgroundMultimorbidity imposes a heavy burden on individuals, families, and society. There are relatively few studies exploring patterns of multimorbidity among middle-aged adults in China.
Bing ZHANG +7 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2017 目的通过评价最近15年来的相关临床实验,使得颈动脉内膜剥脱术后高血压引起的高灌性脑损伤与术后1天内认知功能损伤的相关性能得到明确,得到可靠的结论。方法本研究的质量控制根据系统评价及荟萃分析首选报道项目指南进行。搜索策略为Hypertention OR blood pressure AND postoperative OR Cognitive dysfunction AND Carotid Endarterectomy OR Cognitive impairment AND Carotid ...
黄家明, 王先伟, 李树芃, 陈东
doaj
Zhongguo cuzhong zazhi目的 探讨血清IL-6、胱抑素C（cystatin C，CysC）、三碘甲状腺原氨酸（triiodothyronine，T3）水平以及影像学总负荷评分与脑小血管病（cerebral small vessel disease，CSVD）患者认知障碍的相关性。 方法 回顾性连续纳入2021年1月—2023年1月就诊的CSVD患者，根据住院期间MoCA评分分为认知障碍组和认知功能正常组。收集患者的人口学信息、既往病史、实验室及影像学检查等数据。分析血清IL-6、CysC ...
于世林1，郝春波2 (YU Shilin1, HAO Chunbo2)
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