Results 31 to 40 of about 26,619 (170)
Mechanisms of activity hepatic stellate cells induced myeloid-derived suppressor cells accumulation and migration [PDF]
, 2015 原发性肝癌（hepatocellularcarcinoma，HCC）是全球第五大常见的恶性肿瘤，在肿瘤致死的病因中排名第三位。在全球，每年有超过50万人死于肝癌，且一半以上在中国。随着科学研究的发展，科研人员发现肝癌的发生发展不仅仅是病毒感染、环境因素、基因突变这些因素，肿瘤微环境对肿瘤的发生、发展、复发转移有着重要作用。肝脏是一个具有“免疫特赦”的脏器，肝癌微环境中的非实质细胞及其细胞因子是肝癌的免疫逃逸，复发转移的重要因素。 肝星状细胞（hepaticstellatecell，HSCs ...
许雅苹
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Photocatalytic hydrogen production from water splitting is a promising strategy for sustainable and clean energy generation. However, the design of low‐cost, highly active photocatalysts remains a critical challenge. In this study, covalent organic frameworks (COFs) were loaded onto the surface of Cd0.9Cu0.1S to fabricate COF/Cd0.9Cu0.1S ...
Yue Zhao +3 more
wiley +1 more source
The universal autophagic effect induced by micro- and nanomaterials depends on dispersity and endocytosis [PDF]
, 2016 越来越多的研究显示，大部分纳米材料显著提升细胞自噬水平，并伴随多种毒性反应。这使得纳米材料的自噬效应受到人们的关注。但目前关于纳米材料的性质与自噬效应之间的关系仍未被明确，纳米材料如何引发自噬也尚未可知。本文的研究将对此作出部分解答。全文研究从一个简单现象开始：柠檬酸钠修饰的纳米氧化铁发生聚集之后引发显著的自噬效应，而在分散良好的状态下则不引起自噬。这种现象在不同粒径、不同表面修饰的纳米氧化铁，纳米金，纳米二氧化硅以及不同的细胞系中均存在 ...
黄登通
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT The growing concern over human health issues, driven by increasingly severe electromagnetic pollution from 5G communication, has made the urgent development of high‐performance electromagnetic wave (EMW) absorbing materials. Although carbide‐based materials are promising because of their conductive and polarization losses, existing single ...
Chenqiang Duan +9 more
wiley +1 more source
野生动物学报, 2013 目的:确定毕赤酵母表达东北林蛙皮肤抗菌肽dybowskin-1ST基因的最佳诱导表达条件。方法:本研究将PCR合成的dybowskin-1ST基因克隆到毕赤酵母表达载体pPIC9K中,构建pPIC9K-dybowskin-1ST诱导型表达载体。表达载体经线性化后转化巴斯德毕赤酵母GS115,应用BMMY培养基诱导表达。采用单一变量法及正交试验法,对甲醇诱导的浓度、时间和温度进行了优化,通过SDS-PAGE电泳分析和体外抑菌试验检测目的肽表达丰度。结果:最佳诱导条件:甲醇终浓度为0.5%、诱导时间为72 ...
崔绍鹏 +4 more
doaj
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Platinum (Pt)‐based catalysts are crucial for the commercialization of hydrogen/metal air batteries, but they suffer from Pt scarcity, high cost, and nanoparticle dissolution/agglomeration, mainly leading to performance degradation. We address this by synthesizing a PtFe alloy catalyst (PtFe–PA–NC) via a phytic acid (PA) assisted pyrolysis ...
Chenyang Shu +9 more
wiley +1 more source
Huli yanjiu, 1989 诱导导尿是一种诱导尿潴留病人排尿的方法.此法简便易学,无付作用.但这种方法往往被人们忽视.本人曾遇一例,经多次行导尿术失败,而用诱导导尿成功的患儿,现报道如下;典型病例郭某、男、9岁,行单侧腹股沟斜病修补术后4小时,下腹部膨胀,排尿困难,责任护士草率诱导导尿,无效后,便匆忙行导尿术,多次插管均未成功 ...
贾海青
doaj
OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis [PDF]
, 2016 关于TGF-β信号在诱导上皮-间质转化（EMT）过程中的作用的研究在多种肿瘤中已经取得了很大的进展，然而，在乳腺肿瘤转移的过程中，TGF-β信号对EMT的调控机制尚未完全探明。在本研究中，我们证明了OVOL2，一种锌指蛋白转录因子，能抑制小鼠肿瘤细胞、人乳腺肿瘤细胞中的TGF-β信号诱导的EMT。从Oncomine数据库中获得的数据表明，OVOL2的表达与乳腺癌的进展之间存在着很强的负相关关系。此外，我们的实验表明，OVOL2在多个水平上抑制TGF-β信号，包括抑制Smad4mRNA的表达 ...
吴容思
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Fe‐based amorphous alloys are attractive soft magnetic materials for next‐generation power electronics, yet simultaneously achieving high saturation magnetic flux density (Bs), low coercivity (Hc), and low core loss under scalable processing conditions remains challenging.
Zhi‐Jun Guo +10 more
wiley +1 more source
Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b [PDF]
, 2016 目的：原发性肝细胞癌(hepatocellularcarcinoma，HCC)是我国公共卫生关注的热点问题之一，寻找增强HCC化疗敏感性的有效干预靶点具有重要意义。蛋白磷酸酶2A(proteinphosphatase2A，PP2A)是重要的肿瘤抑制因子；PPP2R2D基因编码的PP2A-B55δ亚基参与细胞周期有丝分裂调控。我们前期研究验证了PPP2R2D基因3’-非翻译区(3’-untranslatedregion，3’UTR)的+15G>C多态性位点受微小RNA-133b(microRNA-133b，
庄群瑛
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