Effects of Cinacalcet HCl on Secondary Hyperparathyroidism and Renal Injury in the Uremic Rat [PDF]
, 2016 目的 慢性肾脏病患者随着肾脏功能的逐渐减退，早期即可出现钙磷失衡、维生素D缺乏、甲状旁腺激素以及成纤维生长因子FGF23的升高，而这种矿物质代谢紊乱又可促使患者出现继发性甲状旁腺功能亢进以及加重肾脏损伤。目前CaSR激动剂作为有效抑制甲状旁腺增生的临床药物，适用于已发生SHPT的透析患者，为探究其是否也能防治继发性甲状旁腺亢进、矿物质代谢紊乱及肾脏损伤，本研究通过5/6肾大部切除术结合高磷饮食建立尿毒症大鼠模型，分别在造模成功早期预防性给予大鼠西那卡塞干预以及在大鼠慢性肾衰确立后给予盐酸西那卡塞干预 ...
孙青宜
core
Protection Effect of Exogenous Fibroblast Growth Factor 21 on the Kidney Injury in Vascular Calcification Rats [PDF]
, 2018 Background: Chronic kidney disease (CKD) is closely related to the cardiovascular events in vascular calcification (VC). However, little has known about the characteristics of kidney injury caused by VC.
Cheng, Shu-Juan +8 more
core +3 more sources
Laser‐Driven Halide Exchange and High‐Resolution Multicolor Patterning of Perovskite Films
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Translating the excellent properties of metal halide perovskites (MHPs) into practical flexible optoelectronic devices requires high‐resolution multicolor patterning techniques that are compatible with post‐fabrication processing. However, such a capability has remained elusive.
Shu Yang +6 more
wiley +1 more source
Effects of FGF on the growth and development of Echinococcus multilocularis and its molecular mechanism [PDF]
, 2015 泡状棘球蚴病是由多房棘球绦虫续绦期幼虫引起的一种严重威胁人类生命安全的人兽共患寄生虫病，泡球蚴在宿主体内的生长发育过程受到宿主生长因子的影响。本文在实验室成功构建的泡球蚴体外培养体系的基础上，探讨宿主成纤维生长因子FGF与泡球蚴生长发育的相互关系，并初步阐述了FGF通过调控泡球蚴体内的ERK信号通路影响泡球蚴生长发育的分子机制。本文主要包括以下内容： （1）FGF影响体外培养泡球蚴的生长过程。分别从FGF影响泡球蚴囊泡的存活率、生长率来阐述FGF对于泡球蚴的生长过程的影响。在有血清和无血清培养液中 ...
王亮
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Expanding near‐infrared (NIR) spectral response and utilizing ultraviolet (UV) photons are effective strategies for enhancing the power conversion efficiency (PCE) of lead halide perovskite solar cells (PSCs). However, the range of NIR spectral response extension and the utilization of UV light for devices are not enough, and the loss of ...
Li He +9 more
wiley +1 more source
The effects of miR-30c-1-3p regulating group ⅡA secretory phospholipase A2（sPLA2-ⅡA）expression on the pathogenic mechanism of atherosclerosis [PDF]
, 2015 动脉粥样硬化（Atherosclerosis，AS）是急性冠脉综合症、脑卒中等众多心脑血管疾病共同的病理基础。sPLA2-ⅡA在动脉粥样硬化病变处含量明显增多、活性显著增强，同时伴随中性粒细胞的增多。sPLA2-ⅡA以酶的催化水解作用和作为致炎因子的促炎症反应双重生物学作用参与AS发生发展的各个阶段。 MicroRNA（miRNA）是近年发现广泛存在于真核细胞中的高度保守的、非编码单链小分子RNA，具有最广泛的基因调节功能，参与机体多种生理、病理过程的调控。 我们运用miRNA靶基因预测软件发现miR ...
夏小春
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT The development of high‐efficiency, stable, and scalable perovskite solar cells/perovskite solar modules (PSCs/PSMs) highly depends on the performance and cost‐effectiveness of functional layers such as electron transport layers (ETLs) and hole transport layers (HTLs).
Baochang Wang +11 more
wiley +1 more source
中性鞘磷脂酶2/神经酰胺调节高磷高钙诱导的血管平滑肌细胞成骨样分化和钙化
Zhongshan Daxue xuebao. Yixue kexue ban, 2018 ： 【目的】阐明nSMase2是否调控高磷高钙诱导的血管平滑肌细胞钙化。【方法】采用人血管平滑肌细 胞钙化体外模型，用高磷高钙诱导血管平滑肌细胞钙化。分别用鞘磷脂酶抑制剂GW4869和siRNA干扰敲低 nSMase2 处理血管平滑肌细胞，检测骨相关蛋白 BMP2、Runx2、Osterix 的表达和细胞钙化程度。【结果】在细胞 钙化过程中 nSMase2 的表达水平和神经酰胺的含量增高 ...
梁青春, 陈燕亭, 陆立鹤
doaj
A Multifunctional Reducing Molecular Dopant for 16% Efficient Tin Perovskite Solar Cells
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Although lead‐based photovoltaics have seen remarkable progress, tin‐based perovskite solar cells (Sn‐PSCs) continue to face challenges due to their limited power conversion efficiency and insufficient operational stability. The primary cause of this performance gap is the susceptibility of Sn2+ to oxidation, which promotes rapid defect ...
Xianyong Zhou +12 more
wiley +1 more source
Toxic effect of carbon dioxide and water soluble fractions of crude oil on marine madaka’s reproductive system [PDF]
, 2016 海洋酸化和原油污染对海洋鱼类的影响时有报道，但海洋酸化和原油污染及两者联合暴露对海洋鱼类生殖系统的影响却鲜见报道。本实验以黑点青鳉为实验动物模型，分别采用原油组（500μg/LWSF）、酸化组（1500ppmCO2）和混合暴露组（1500ppmCO2+500μg/LWSF）对黑点青鳉从受精卵开始暴露，探究海洋酸化和原油污染对海洋鱼类的生殖系统的毒性作用及可能机制，结果如下： 原油水溶性成分和二氧化碳暴露的雄鱼表现出精细胞的成熟延迟，并且精原细胞的分裂和分化都受到影响；雌鱼则表现出卵细胞的成熟加速 ...
卢梦超
core