[Clinical features and prognosis of Pseudomonas aeruginosa infection in patients with hematologic malignancies]. [PDF]
Zhonghua Xue Ye Xue Za Zhi目的 探讨恶性血液病患者发生铜绿假单胞菌感染的临床特征及预后影响因素。 方法 回顾性分析2019年1月1日至2021年12月31日期间在福建医科大学附属协和医院血液科住院的197例合并铜绿假单胞菌感染的恶性血液病患者的临床资料。根据对碳青霉烯类药物的敏感性分为敏感组（CSPA感染组）和耐药组（CRPA感染组），比较两组患者临床特征的差异，分析容易发生CRPA感染的危险因素及预后情况。 结果 Logistic回归多因素分析显示住院天数>50 d（P＝0.010，OR＝3.581，95％CI 1.356～9.
Gao HZ +5 more
europepmc +2 more sources
Whole genome analysis and molecular traceability of Pseudomonas aeruginosa in drinking water [PDF]
, 2023 Objective: Provide data support for the source tracing and pollution prevention of Pseudomonas aeruginosa in drinking water in Hunan Province. Methods: According to the national food safety standards of GB 8538—2016, the bottled water was tested randomly
GAO Han +5 more
core +1 more source
Analysis of characteristics of infectious pathogens in malignant tumors combined with bloodstream infection and significance of serum glucose detection [PDF]
, 2023 Background and purpose: The incidence rate of bloodstream infection (BSI) in patients with malignant tumor increases gradually with the progress of anti-tumor treatment. The treatment outcome is closely related to the infection of pathogen.
CHEN Zhujun, DING Zhimin, MA Xiaolu, WANG Yanchun, HU Haoyun, LU Renquan, GUO Lin
core +1 more source
Development and evaluation of a real-time recombinase-aid amplification assay for rapid detection of Pseudomonas aeruginosa [PDF]
, 2020 Objective To establish a real-time recombinase-aid amplification (RAA) method for rapid detection of Pseudomonas aeruginosa. Methods Specific primers and exo probes based on ecfX gene of P.
Jialin XIANG +8 more
core +1 more source
Distribution of blood culture pathogens and clinical characteristics in children with acute leukemia complicated with septic shock [PDF]
, 2022 Objective To explore the distribution of blood culture pathogens and clinical characteristics in children with acute leukemia complicated with septic shock.
Liu Tinghua, Lei Jiaying, Mai Yougang
core +1 more source
Analysis of global burden of bacterial infections: an interpretation of Global mortality associated with 33 bacterial pathogens in 2019 [PDF]
, 2023 The Global Burden of Bacterial Infections report showed that in 2019, there were approximately 13.7 million deaths worldwide due to infection (95% UI ranging from 10.9 million to 17.1 million), and bacterial infection related deaths accounted for 13.6 ...
ZHANG Ying, JIANG Xiaofei
core +1 more source
Recent Advances in the Regulation Mechanism of Initial Adhesion during Biofilm Formation and Its Application in Food Quality Control [PDF]
, 2023 Bacteria mainly exist in the form of a biofilm in nature. The initial adhesion of bacteria starts the life cycle of biofilm formation. Initial adhesion is a process in which bacteria in a planktonic state adsorb on biotic/abiotic surfaces and begin to ...
XIONG Ruheng, YAN Jun, XIE Jing
core +1 more source
Optimization of β lactam antibiotics regimens against bloodstream infection caused by Pseudomonas aeruginosa [PDF]
, 2017 目的制定某院B内酰胺类在铜绿假单胞菌（PA）血流感染中的治疗方案。方法收集某院2015年至2016年血培养中铜绿假单胞菌共64株，测定B内酰胺类（哌拉西林／他唑巴坦，头孢他啶，头孢吡肟，亚胺培南，美罗培南）对铜绿假单胞菌的最低抑菌浓度（MIC）。用蒙特卡洛模拟计算多种治疗方案的达标率（PrA）和累积反应分数（CFR）。结果经验治疗时，哌拉西彬他唑巴坦4．5g（q6h），头孢他啶2g（q8h），头孢吡肟2g（q8h），亚胺培南1g（q6h），美罗培南1g（q8h，q6h），共6种方案的CFR值〉90 ...
于迪 +4 more
core +1 more source
, 2018 抗生素发现\"黄金时代\"的结束以及日趋严重的抗生素耐药性问题给我们留下一个戏剧性的、缺乏新型药物来防治耐药病原体感染的难题。这使得从现有非抗生素药物中筛查抗菌活性药物成为一种新尝试。近期研究表明:美国食品药品监督管理局(FDA)批准的、本来用于治疗高血钙的药物硝酸镓具有良好的抗菌活性。不同于其他抗生素,镓的药理性质依靠化学拟态,它可以在目标酶分子中取代铁,从而干扰、扰乱细菌含铁蛋白的功能及细菌代谢,无论是在体外实验还是在体内实验中,镓对多种病原体,包括多重耐药病原体都表现出杀菌活性 ...
刘周 +6 more
core +1 more source
, 2018 近年来的研究发现,细菌应答抗生素压力时会产生特异的非编码小RNA(small RNA,sRNA)谱,进而可能调控下游基因的表达,帮助细菌克服抗生素压力。sRNA以各种方式调控细菌耐药相关基因(如抗生素转运蛋白、药物外排泵、细胞被膜的合成与修饰),参与细菌耐药网络。因此,sRNA及其相关因子(如Hfq)可能被用作抗菌治疗的靶标。本文将从sRNA应答抗生素压力并产生抗生素耐药及其作为药物靶点的前景等方面,综述sRNA在细菌耐药调控方面的研究进展。国家自然科学基金(No.31370166、No ...
方鼎丽, 李娜, 洪守强, 王岱
core +1 more source