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Recent Advances in the Regulation Mechanism of Initial Adhesion during Biofilm Formation and Its Application in Food Quality Control [PDF]
, 2023 Bacteria mainly exist in the form of a biofilm in nature. The initial adhesion of bacteria starts the life cycle of biofilm formation. Initial adhesion is a process in which bacteria in a planktonic state adsorb on biotic/abiotic surfaces and begin to ...
XIONG Ruheng, YAN Jun, XIE Jing
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Veterinary Dermatology, Volume 27, Issue 5, Page 391-e98, October 2016., 2016 Background– Pseudomonas aeruginosa (PA) may cause suppurative otitis externa with severe inflammation and ulceration in dogs. Multidrug resistance is commonly reported for this organism, creating a difficult therapeutic challenge. Objective– The aim of this study was to evaluate the in vitro antimicrobial activity of a gel containing 0.5 µg/mL of ...
Giovanni Ghibaudo +6 more
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, 2018 近年来的研究发现,细菌应答抗生素压力时会产生特异的非编码小RNA(small RNA,sRNA)谱,进而可能调控下游基因的表达,帮助细菌克服抗生素压力。sRNA以各种方式调控细菌耐药相关基因(如抗生素转运蛋白、药物外排泵、细胞被膜的合成与修饰),参与细菌耐药网络。因此,sRNA及其相关因子(如Hfq)可能被用作抗菌治疗的靶标。本文将从sRNA应答抗生素压力并产生抗生素耐药及其作为药物靶点的前景等方面,综述sRNA在细菌耐药调控方面的研究进展。国家自然科学基金(No.31370166、No ...
方鼎丽, 李娜, 洪守强, 王岱
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, 2018 目的了解医院血培养病原菌的菌种分布及常见病原菌的耐药情况,为临床用药提供参考依据。方法对2017年1～12月临床送检的血培养标本进行回顾性统计分析。结果 4 447份血培养标本共分离出病原菌225株,阳性检出率为5. 1%。主要病原菌:大肠埃希菌82株占36. 4%、凝固酶阴性葡萄球菌31株占13. 8%、肺炎克雷伯菌17株占7. 6%、铜绿假单胞菌10株占4.
廖蕴惠, 赵军
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Drug-herb interactions between Scutellaria baicalensis and pharmaceutical drugs : insights from experimental studies, mechanistic actions to clinical applications [PDF]
, 2021 Whilst the popular use of herbal medicine globally, it poses challenges in managing potential drug-herb interaction. There are two folds of the drug-herb interaction, a beneficial interaction that may improve therapeutic outcome and minimise the toxicity
Fu, Ling +5 more
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Veterinary Dermatology, Volume 36, Issue 2, Page 148-158, April 2025.Background – Biofilm production by canine otitis externa (COE) pathogens and resistance development to multiple antimicrobials are commonly reported problems in veterinary practice. The use of adjuvants to disrupt biofilms may be a viable adjunctive therapy.
Bhumika F. Savaliya +3 more
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Optimization of beta lactam antibiotics regimens against bloodstream infection caused by Pseudomonas aeruginosa [PDF]
, 2017 目的制定某院beta内酰胺类在铜绿假单胞菌(PA)血流感染中的治疗方案。方法收集某院2015年至2016年血培养中铜绿假单胞菌共64株,测定; beta内酰胺类(哌拉西林/他唑巴坦,头孢他啶,头孢吡肟,亚胺培南,美罗培南)对铜绿假单胞菌的最低抑菌浓度(MIC)。用蒙特卡洛模拟计算多种治疗; 方案的达标率(PTA)和累积反应分数(CFR)。结果经验治疗时,哌拉西林/他唑巴坦4.5 g(q6 h),头孢他啶2 g(q8 h),头孢吡肟2; g(q8 h),亚胺培南1 g(q6 h),美罗培南1 g(q8 h,
于迪 +4 more
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Veterinary Dermatology, Volume 35, Issue 3, Page 325-336, June 2024.Background – Norway spruce (Picea abies) resin‐based products are used in human medicine. A resin‐based otic rinse also could be useful in supportive care of canine otitis externa (COE), yet information on its antimicrobial effect against canine pathogens or ototoxicity is lacking.
Elina Aimo‐Koivisto +5 more
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SPF级实验小鼠4种致病菌多重PCR方法的建立及优化 [PDF]
, 2018 目的建立一种可同时检测4种SPF级屏障环境常见致病菌的多重PCR方法。方法本研究针对鼠伤寒沙门氏菌inv A基因、肺炎克雷伯杆菌khe基因、嗜肺巴斯德菌16SrRNA基因、铜绿假单胞菌ecf X基因序列分别设计合成特异性引物,构建可同时鉴别4种菌的多重PCR反应体系,优化后测定其特异性、灵敏性并人工模拟感染样本。结果建立的4重PCR方法能对同一样品中的4种致病菌模板进行特异性扩增,无交叉反应;对4种目的菌的检测灵敏度为10-3ng/μL;也可从混合感染的病料中特异性地检测出4种致病菌 ...
张越华, 郑秀青
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Progress in Research on Bacteriophage Receptor-Binding Proteins and Host Range Extension [PDF]
, 2023 Phages are one of the most diverse and widely distributed organisms on the earth today, and have great advantages in eliminating bacteria, especially multi-drug resistant bacteria that are widespread at present.
LI Fan, YU Zhenxing, ZHANG Ming, LIN Hong, LI Xuepeng, LI Jianrong, ZHANG Defu
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