Results 81 to 90 of about 1,178 (146)
Progress in the role of exosomes in sepsis⁃induced cardiomyopathy [PDF]
"Sepsis is a life⁃ threatening organ dysfunction triggered by a dysregulated host response to infection. Sepsis⁃ induced cardiomyopathy（SICM）is an acute cardiac condition caused by sepsis，characterized by high incidence and extremely high mortality ...
ZHENG Ye*，LI Shaoling，HAN Fei
core +2 more sources
长链非编码RNA CCAT1调控MAPK信号通路对于胶质瘤细胞的影响
Zhongguo shiyan zhenduanxue, 2020 目的探讨长链非编码RNA CCAT1表达对人胶质瘤细胞U251增殖、侵袭能力的影响及其作用机制。方法选取人胶质瘤细胞U251进行转染实验,分为空白组、sh-NC组和sh-CCAT1组;利用实时荧光定量qRT-PCR检测抑制效果;采用MMT、Transwell试验检测下调CCAT1对于胶质瘤细胞增殖、侵袭能力的影响;利用Western blot检测丝裂原活化蛋白激酶(MAPK)信号通路相关分子的表达变化。结果在转染48h后,sh-CCAT1组CCAT1的表达较NC组和sh-NC组显著降低 ...
王春辉 +4 more
doaj
长链非编码RNA FOXD3-AS1在急性髓系白血病中的表达及功能
Zhongguo shiyan zhenduanxue, 2022 目的 探究长链非编码RNA FOXD3-AS1(LncRNA FOXD3-AS1)在急性髓系白血病（AML）患者骨髓单个核细胞（PBMCs）中表达及在AML中的功能。方法 选择2015年1月-2017年6月血液科收治AML（非M3型）患者73例作为观察组，选择另选择同期健康志愿者75例作为对照组。采集两组观察对象骨髓标本，采用实时荧光定量PCR(qRT-PCR)法检测骨髓PBMCs中LncRNA FOXD3-AS1表达情况，分析LncRNA FOXD3-AS1表达与AML患者临床病理特征及预后的相关性 ...
鲁猛, 刘香来, 王芳, 赵耀顺
doaj
[Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2022 Shi X, Ni H, Li M, Wu Y, Xu Y.
europepmc +1 more source
Protective effect of dihydromyricetin against hippocampal neuronal injury caused by iron overload and its mechanism [PDF]
Objective To investigate the protective effect of dihydromyricetin (DMY) against injury of primary hip-pocampal neurons caused by ferric ammonium citrate (FAC) and its mechanism.
SUI Yunjie, MA Zegang
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尿外泌体非编码RNA在糖尿病肾病发病机制及诊断中的最新研究进展
Zhongguo shiyan zhenduanxue糖尿病肾病（diabetic kidney disease,DKD）如今占所有导致终末期肾病（end-stage renal disease ESRD）原发病的近50%[1]。目前糖尿病肾病的诊断及分期主要依靠尿微量白蛋白的检测，其缺点是敏感性和特异性相对较低，而肾穿刺活检术则操作风险较高，尚缺少采集程序无创性的理想检测标志物。外泌体是直径范围40～160nm被脂质双层膜包裹的囊泡，广泛分布于血液、尿液等体液中。尿液中的外泌体是一种易采集的非侵入性生物标志物 ...
杨文昊, 云志飞, 李倩玉, 刘锋
doaj
Zhongguo shiyan zhenduanxue, 2017 目前,心血管疾病已经成为了严重威胁人类生命健康的重大慢性疾病之一。尽管日益发展的医疗技术使心血管疾病的患者经过医治后,症状能够得到一定的缓解,生活质量得到改善,但是至今仍无法从根本上使心血管疾病得到逆转或终止其进一步发展。不仅如此,相比于过去几十年,人类新的不良生活习惯也渐渐成为心血管疾病新的危险因素 ...
赵洋 +4 more
doaj
Zhongguo shiyan zhenduanxue, 2020 胃癌是一种较为常见的消化道肿瘤疾病,其发病率和死亡率分别位居第4位和低2位[1]。目前CA199、CA724等血清标志物对胃癌的诊断有提示作用,但是胃癌的诊断主要依据胃镜检查。早期胃癌经手术切除后生存率可达90%以上 ...
程玉华, 连丽丽, 董红梅, 丁璐
doaj
Screening and analysis for autophagy-related lncRNA in fibroblast-like synoviocytes from patients with rheumatoid arthritis. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Shang H, Peng Q, Liu J, Liu Y, Long L.
europepmc +1 more source
Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection [PDF]
Heart transplantation is an effective treatment for patients with end-stage heart failure, but faces challenges such as organ shortage and rejection.
LIU Dezhao, ZENG Zhiyu
core +1 more source