Results 81 to 90 of about 1,357 (146)
The role of ferroptosis suppressor protein 1 in tumors [PDF]
Ferroptosis suppressor protein 1 （FSP1） is a key suppressor in the process of ferroptosis， which can prevent cell death and has important biological functions and potential value in clinical application.
LI Hantong, LI Yuefan, ZHOU Yan, WANG Lin
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长链非编码RNA FOXD3-AS1在急性髓系白血病中的表达及功能
Zhongguo shiyan zhenduanxue, 2022 目的 探究长链非编码RNA FOXD3-AS1(LncRNA FOXD3-AS1)在急性髓系白血病（AML）患者骨髓单个核细胞（PBMCs）中表达及在AML中的功能。方法 选择2015年1月-2017年6月血液科收治AML（非M3型）患者73例作为观察组，选择另选择同期健康志愿者75例作为对照组。采集两组观察对象骨髓标本，采用实时荧光定量PCR(qRT-PCR)法检测骨髓PBMCs中LncRNA FOXD3-AS1表达情况，分析LncRNA FOXD3-AS1表达与AML患者临床病理特征及预后的相关性 ...
鲁猛, 刘香来, 王芳, 赵耀顺
doaj
Research advances in platinum resistance and its treatment in ovarian cancer [PDF]
Ovarian cancer is one of the most malignant gynecological tumors. Platinum-based chemotherapy is an important part of ovarian cancer treatment, with platinum resistance as a difficult problem in ovarian cancer treatment. Platinum resis-tance is a complex
LIU Yan, HUANG Li
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尿外泌体非编码RNA在糖尿病肾病发病机制及诊断中的最新研究进展
Zhongguo shiyan zhenduanxue糖尿病肾病（diabetic kidney disease,DKD）如今占所有导致终末期肾病（end-stage renal disease ESRD）原发病的近50%[1]。目前糖尿病肾病的诊断及分期主要依靠尿微量白蛋白的检测，其缺点是敏感性和特异性相对较低，而肾穿刺活检术则操作风险较高，尚缺少采集程序无创性的理想检测标志物。外泌体是直径范围40～160nm被脂质双层膜包裹的囊泡，广泛分布于血液、尿液等体液中。尿液中的外泌体是一种易采集的非侵入性生物标志物 ...
杨文昊, 云志飞, 李倩玉, 刘锋
doaj
Zhongguo shiyan zhenduanxue, 2017 目前,心血管疾病已经成为了严重威胁人类生命健康的重大慢性疾病之一。尽管日益发展的医疗技术使心血管疾病的患者经过医治后,症状能够得到一定的缓解,生活质量得到改善,但是至今仍无法从根本上使心血管疾病得到逆转或终止其进一步发展。不仅如此,相比于过去几十年,人类新的不良生活习惯也渐渐成为心血管疾病新的危险因素 ...
赵洋 +4 more
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长链非编码RNA CCAT1调控MAPK信号通路对于胶质瘤细胞的影响
Zhongguo shiyan zhenduanxue, 2020 目的探讨长链非编码RNA CCAT1表达对人胶质瘤细胞U251增殖、侵袭能力的影响及其作用机制。方法选取人胶质瘤细胞U251进行转染实验,分为空白组、sh-NC组和sh-CCAT1组;利用实时荧光定量qRT-PCR检测抑制效果;采用MMT、Transwell试验检测下调CCAT1对于胶质瘤细胞增殖、侵袭能力的影响;利用Western blot检测丝裂原活化蛋白激酶(MAPK)信号通路相关分子的表达变化。结果在转染48h后,sh-CCAT1组CCAT1的表达较NC组和sh-NC组显著降低 ...
王春辉 +4 more
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MiRNA调控脑缺血/再灌注诱导的自噬信号通路研究进展 [PDF]
脑卒中时缺血缺氧致脑组织功能损伤，且缺血后脑组织再恢复血液供应时，大量自由基、钙超载等引起脑缺血/再灌注损伤，进一步加重病情。自噬是一种维持细胞内环境稳态的自我保护机制，但过度自噬引起脑组织损伤。MiRNA为小的内源性非编码RNA分子，通过与其靶基因mRNA的3’ -UTR中的互补序列结合，导致翻译抑制或mRNA降解，从基因水平上调控多种生理活动。MiRNA不仅直接作用于自噬相关蛋白，还可通过多种信号通路，参与缺血/再灌注诱导的自噬调控。但关于miRNA调控脑缺血 ...
刘筱蔼, 罗友根
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[Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2022 Shi X, Ni H, Li M, Wu Y, Xu Y.
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Screening and analysis for autophagy-related lncRNA in fibroblast-like synoviocytes from patients with rheumatoid arthritis. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Shang H, Peng Q, Liu J, Liu Y, Long L.
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Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection [PDF]
Heart transplantation is an effective treatment for patients with end-stage heart failure, but faces challenges such as organ shortage and rejection.
LIU Dezhao, ZENG Zhiyu
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