Results 131 to 140 of about 214 (150)

Luminescence Spectra Simulation of Ce3+‐Activated Phosphors by Accumulating Emission Lines Along First‐Principles Molecular Dynamics Trajectories

Advanced Theory and Simulations, Volume 9, Issue 6, June 2026.
A density functional theory‐based method is introduced to predict the luminescence emission spectra of candidate compounds, including broadening caused by atomic thermal motion. For each snapshot from the molecular dynamics of the Ce‐activated system using the excited‐state electron configuration, the transition energies and probabilities are ...
Satoru Matsuishi, Hidekazu Ikeno, Yukinori Koyama, Takashi Takeda   +3 more
wiley   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Identification of Novel Small‐Molecule Inhibitors Targeting KDM5B and Evaluation of Their Antitumour Effects

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT KDM5B, a member of the KDM5 family of histone demethylases, plays a critical role in transcriptional repression by demethylating H3K4me2/3. It regulates key biological processes such as development, stem cell maintenance, and oncogenesis, and its aberrant expression is implicated in various cancers. Accordingly, KDM5B is considered a promising
Tomoaki Hara, Sikun Meng, Masamitsu Konno, Naohiro Nishida, Jun Koseki, Kanji Meguro, Yasuhiko Kawano, Toshiya Morie, Shingo Dan, Taroh Satoh, Shuji Akai, Kazutake Tsujikawa, Hidetoshi Eguchi, Masaki Mori, Yutaka Miura, Nobuhiro Nishiyama, Hideshi Ishii   +16 more
wiley   +1 more source

A Short Synthesis of Cyclo(‐RGDfK) Using a Microflow Reactor

ChemistryEurope, Volume 4, Issue 6, June 2026.
An efficient synthesis of cyclo(‐RGDfK) was achieved by combining a one‐flow three‐component coupling (3CC) reaction via α‐amino acid N‐carboxy anhydrides with rapid macrolactamization using a microflow reactor. Precise control of the water content and base loading in the 3CC reaction enabled the gram‐scale synthesis of the desired tripeptides and ...
Naoto Yamasaki, Mina Kim, Kana Miyamoto, Yuma Otake, Kyohei Adachi, Daisuke Kubo, Shinichiro Fuse   +6 more
wiley   +1 more source

Facile Synthesis of Dicyclohepta[cd,fg]‐as‐indacene and Confirmation of its Anti‐Kasha S3 Emission

ChemistryEurope, Volume 4, Issue 6, June 2026.
A six‐step synthesis of dicyclohepta[cd,fg]‐as‐indacene bearing phenyl and methyl groups was developed, which was achieved by a new strategy to prepare a 4,4’‐biazulene scaffold via single‐electron reduction‐induced dimerization of 6‐methylazulene. During the detailed investigation of the photophysics of dicyclohepta[cd,fg]‐as‐indacene, anti‐Kasha ...
Ryoji Hatakenaka, Keitaro Yamamoto, Mitsuaki Yamauchi, Yoshiyuki Mizuhata, Fumito Tani, Toshihiro Murafuji, Hiroko Yamada   +6 more
wiley   +1 more source

In Vitro Live Cell Imaging Reveals Nuclear Dynamics and Role of the Cytoskeleton During Asymmetric Division of Pollen Mitosis I in Nicotiana Benthamiana

Cytoskeleton, Volume 83, Issue 6, Page 394-406, June 2026.
ABSTRACT Pollen is a male gametophyte of angiosperms. Following meiosis, the microspore undergoes an asymmetric division called pollen mitosis I (PMI), which produces two cells of different sizes: a large vegetative cell and a small generative cell. Polarized nuclear migration and positioning during PMI are important for successful pollen development ...
Yoko Mizuta, Masako Igarashi, Tomomi Shinagawa, Ikuma Kaneshiro, Haoto Anan, Daisuke Kurihara   +5 more
wiley   +1 more source

Efficient Gene Expression System in Medaka Embryos Enables Functional Characterization of nt5c1a Paralogs Involved in Inosine Monophosphate Metabolism

genesis, Volume 64, Issue 3, June 2026.
ABSTRACT Optimizing transient expression systems in fish embryos is crucial for rapid gene function analysis. Here, we established an efficient system in medaka (Oryzias latipes) embryos by evaluating nucleic acid type and injection site. Our results revealed that injecting the elongation factor 1αA (ef1αA) promoter‐driven plasmid into the yolk yielded
Yu Murakami, Tomohisa Horibe, Masashi Ando, Toru Kobayashi   +3 more
wiley   +1 more source