Zhongguo shiyan zhenduanxue, 2021 在病因和发病机制的TOAST分型中,以大动脉粥样硬化型脑梗死最为常见。随着分子生物学技术的发展,越来越多的microRNA被发现参与机体代谢的各个途径,对动脉粥样硬化斑块形成起到重要调节作用。本文针对大动脉粥样硬化型脑梗死发生、发展的关键环节,综述了microRNA在其中的作用和预测价值。1 miRNA概述微小核糖核苷酸(MicroRNAs),简称miRNA,长度18-25个核苷酸[1],为内源性单链非编码RNA。其通过与特定的信使RNA(mRNAs ...
doaj
Application of Forensic Transcriptomics in the Identification of Tissue Origin of Body Fluid Stains [PDF]
The inference of tissue origin of body fluid stains is crucial for case investigation and court proceedings. However, traditional methods for identification of body fluid stains, such as morphological, chemical, and immunoassay identifications have ...
BAI Yi-fan +5 more
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Screening and analysis for autophagy-related lncRNA in fibroblast-like synoviocytes from patients with rheumatoid arthritis. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Shang H, Peng Q, Liu J, Liu Y, Long L.
europepmc +1 more source
假基因来源的lncRNA DUXAP8表观遗传沉默CDKN1A和KLF2促进胰腺癌细胞的生长 [PDF]
, 2019 背景与目的最近研究表明假基因来源的长链非编码RNA(long non-coding RNAs,lncRNA)是癌症的关键调控因子。然而,在胰腺癌中却鲜有对lncRNA的鉴定和研究。我们旨在明确假基因来源的lncRNA DUXAP8与胰腺癌细胞生长的关系。方法我们通过比较分析3个来自GEO的独立数据集,筛选出与人胰腺癌相关的假基因来源的lncRNA。通过实时定量反转录PCR检测DUXAP8在胰腺癌组织和细胞中的相对表达水平。应用功能缺失的方法在体外和体内研究DUXAP8对胰腺癌细胞的增殖和凋亡的作用 ...
Chuangxing Xiao +5 more
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Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis [PDF]
Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes,
FAN Zhisong, FENG Li, ZHANG Zongwen
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A preliminary study on the colocalization of miR-574-5p with TLR7/8 in cells and the effects of inhibition of miR-574-5p-TLR7/8 signaling on lupus and lupus nephritis in a line of lupus-prone mice [PDF]
, 2017 MicroRNA(miRNA)是一种小型的非编码RNA，可以识别信使RNA的3’端非编码区进而可使得信使RNA降解抑制其翻译，调控基因的表达。有研究揭示了miRNA非传统性功能，可以与内源性的单链RNA竞争与Toll样受体结合。还有研究表明，在癌症细胞中，miR-21和miR-29a可以与小鼠mTlr7/人hTLR8结合，激活TLR信号通路促进炎症反应。然而，miRNA在自身免疫性疾病中的功能目前还知之甚少。B6.MRL-Faslpr/J小鼠是研究SLE的重要小鼠模型，伴随有自身抗体的产生 ...
张艳
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Research progress on the pathogenesis of acute lung injury in sepsis [PDF]
Sepsis is a systemic inflammatory response syndrome caused by severe infection leading to host dysfunction，often involving multiple organs and causing functional failure.
WANG Qin，YU Xu，LI Qingying，LU Yibin
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野生动物学报, 2020 鹿茸是雄性鹿科动物（除驯鹿外）特有的能够周期性再生的器官，其生长发育受到多种因素的共同调控。miRNA（microRNA）是一类在真核生物中发现的内源性的具有调控功能的非编码RNA，在基因表达调控、细胞周期、生物体发育等方面发挥着重要的调控作用。本文从miRNA的相关技术、鹿茸组织中miRNA的鉴定、miRNA对生长因子的调控作用、miRNA对鹿茸细胞增殖的作用以及miRNA对鹿茸再生调控的研究几个方面就现有miRNA对鹿茸生长发育的研究进行总结和展望，为今后鹿茸生长发育机理的诠释具有一定的意义。
韩若冰 +4 more
doaj
[Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2021 Zhang K +5 more
europepmc +1 more source
Prediction and characteristic research of MicroRNA [PDF]
, 2014 MicroRNA（miRNA）是一种非编码RNA，长度约为22个核苷酸，研究证实miRNA在基因表达中其重要的调控作用。对miRNA进行研究有助于人们了解基因功能，疾病关系以及生物进化规律。近年来，miRNA研究已经成为生物信息学领域重要课题之一，本文研究了miRNA有关了几个热点问题：miRNA预测及其家族预测分类，主要完成的工作为： （1）本文介绍了miRNA相关知识和当前挖掘方法。生物信息学中miRNA的研究大都利用了其生物特性，例如，miRNA序列的保守性，pre ...
胡玲玲
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