Results 81 to 90 of about 2,084 (151)
China-Australia Science and Technology Forum 2010 [PDF]
, 2010 This presentation was originally in Chinese. The following is only a brief description. From metazoan to mammals, the number of protein coding genes and functional scope are broadly similar, about two million, and the functions of these genes encoding ...
Liu, Guang Bin
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尿外泌体非编码RNA在糖尿病肾病发病机制及诊断中的最新研究进展
Zhongguo shiyan zhenduanxue糖尿病肾病（diabetic kidney disease,DKD）如今占所有导致终末期肾病（end-stage renal disease ESRD）原发病的近50%[1]。目前糖尿病肾病的诊断及分期主要依靠尿微量白蛋白的检测，其缺点是敏感性和特异性相对较低，而肾穿刺活检术则操作风险较高，尚缺少采集程序无创性的理想检测标志物。外泌体是直径范围40～160nm被脂质双层膜包裹的囊泡，广泛分布于血液、尿液等体液中。尿液中的外泌体是一种易采集的非侵入性生物标志物 ...
杨文昊, 云志飞, 李倩玉, 刘锋
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[Long non-coding RNA ABHD11-AS1 promotes glycolysis in gastric cancer cells to accelerate tumor progression]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Feng W, Lai Y, Wang J, Xu P.
europepmc +1 more source
Study on the mechanisms and functions of lncRNAs in regulating carboplatin resistance in ovarian cancer cells [PDF]
Objective To screen for differentially expressed long non-coding RNAs (lncRNAs) in carboplatinresistant ovarian cancer (OC) based on expression profiling microarrays and conduct functional enrichment analysis to comprehensively understand the signaling ...
CHEN Cuilan +3 more
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非小细胞肺癌术前循环miR-125和miR-205对预后判断价值比较
Zhongguo shiyan zhenduanxue, 2019 miRNA（小RNA）是长度约为20个核苷酸左右的一类内源保守的非编码RNA分子,在体内通过调控mRNA的翻译发挥生物学作用[1]。miRNA除了存在于组织细胞中,最近报道其在血液中也能稳定存在,并且循环miRNA已被证实在不同的病理条件下存在差异表达,因此其可作为疾病的生物标志分子[2,3 ...
李雪, 安然, 王海荣
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Spatial transcriptome analysis of long non-coding RNAs reveals tissue specificity and functional roles in cancer. [PDF]
J Zhejiang Univ Sci B, 2023 Xu K +10 more
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Transcriptional regulation of Dicer by FoxO3 [PDF]
, 2017 MicroRNAs（miRNAs）是一类16-29nt长的分布极其广泛的小的非编码RNA，作为RNA干扰沉默复合体的一部分，其最主要的作用是特异性靶向结合具有同源序列的mRNA进而负向调控基因的表达，参与调控了几乎所有的信号通路，对于维持机体正常的生物学功能至关重要。研究表明miRNA的异常突变或者异位表达常常伴随着疾病以及癌症。而作为RNA干扰沉默复合体的核心组分，Dicer一方面通过切割外源dsRNA为siRNA介导RNAi抵抗外来核酸的影响，还能通过将内源序列加工成miRNA调节内源基因的表达 ...
董文静
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Lnc-BM Promotes Gastric Cancer Progression by Regulating Mitochondrial Respiratory Function Through FASTK/MT-ND6 Axis [PDF]
Objective To explore the role and molecular mechanism of Lnc-BM in the occurrence and development of gastric cancer (GC). Methods GC tissues and paired adjacent normal tissues of 36 GC patients were collected, and the expression of Lnc-BM was detected by
CHEN Chen +3 more
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血管衰老驱动的动脉粥样硬化：lncRNA与miRNA的多层次调控
Zhongguo shiyan zhenduanxue动脉粥样硬化(atherosclerosis, AS)是心脑血管事件的核心病理基础，其发生发展与血管衰老密切相关。血管衰老可通过内皮功能障碍、氧化应激、炎症反应和自噬缺陷等途径促进斑块形成与进展。非编码RNA(non-coding RNA, ncRNA)，尤其是长链非编码RNA(long non-coding RNA, lncRNA)和微小RNA(microRNA, miRNA)，在AS发生发展中发挥多层次调控作用，显著影响血管内皮细胞和血管平滑肌细胞的衰老表型与功能状态，从而影响AS病程 ...
徐长霖 +4 more
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胃癌患者血清中miR-204水平变化及与幽门螺杆菌感染的关系
Zhongguo shiyan zhenduanxue, 2017 幽门螺杆菌（Hp）感染已经被国际癌症研究机构列为第一类癌病致病原[1]。目前大量研究已证实Hp感染与胃癌发生、发展密切相关,但具体机制尚不清楚。微小RNA（miRNA）是一种单链RNA,目前研究认为其具有非编码性和高度保守性[2]。Calin[3]研究发现有超过半数的miRNA的基因所在区域与肿瘤有关,诸如杂合子缺失的微小区域 ...
周保贞 +3 more
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