[Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Wang H, Li W, Zhang D.
europepmc +1 more source
Plasticizer DEHP exposure in early pregnancy affects the endometrial decidualization in mice through reducing lncRNA RP24-315D19.10 expression. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2023 Yuan L +6 more
europepmc +1 more source
Prediction and characteristic research of MicroRNA [PDF]
, 2014 MicroRNA（miRNA）是一种非编码RNA，长度约为22个核苷酸，研究证实miRNA在基因表达中其重要的调控作用。对miRNA进行研究有助于人们了解基因功能，疾病关系以及生物进化规律。近年来，miRNA研究已经成为生物信息学领域重要课题之一，本文研究了miRNA有关了几个热点问题：miRNA预测及其家族预测分类，主要完成的工作为： （1）本文介绍了miRNA相关知识和当前挖掘方法。生物信息学中miRNA的研究大都利用了其生物特性，例如，miRNA序列的保守性，pre ...
胡玲玲
core
Protective effect of dihydromyricetin against hippocampal neuronal injury caused by iron overload and its mechanism [PDF]
Objective To investigate the protective effect of dihydromyricetin (DMY) against injury of primary hip-pocampal neurons caused by ferric ammonium citrate (FAC) and its mechanism.
SUI Yunjie, MA Zegang
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[Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2022 Shi X, Ni H, Li M, Wu Y, Xu Y.
europepmc +1 more source
Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis [PDF]
Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes,
FAN Zhisong, FENG Li, ZHANG Zongwen
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野生动物学报, 2020 鹿茸是雄性鹿科动物（除驯鹿外）特有的能够周期性再生的器官，其生长发育受到多种因素的共同调控。miRNA（microRNA）是一类在真核生物中发现的内源性的具有调控功能的非编码RNA，在基因表达调控、细胞周期、生物体发育等方面发挥着重要的调控作用。本文从miRNA的相关技术、鹿茸组织中miRNA的鉴定、miRNA对生长因子的调控作用、miRNA对鹿茸细胞增殖的作用以及miRNA对鹿茸再生调控的研究几个方面就现有miRNA对鹿茸生长发育的研究进行总结和展望，为今后鹿茸生长发育机理的诠释具有一定的意义。
韩若冰 +4 more
doaj
Zhongguo shiyan zhenduanxue, 2018 微小RNA(miRNA)是内源性非编码的小分子RNA的一个种类,大约只有18-25个bp的长度。在动物基因组中,它大多以单拷贝、多拷贝或基因簇等形式广泛存在着。它虽然只是占人类基因组的约1%的内容,但是人类将近三成的基因却受其调节。它不但可作为癌基因存在,也可以作为抑癌基因而起到作用。在Mitchell等人[1]的研究中已证明外周血血浆中存在稳定的miRNA。miR ...
王先伟, 陈东, 李召磊
doaj
Screening and analysis for autophagy-related lncRNA in fibroblast-like synoviocytes from patients with rheumatoid arthritis. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Shang H, Peng Q, Liu J, Liu Y, Long L.
europepmc +1 more source
A preliminary study on the colocalization of miR-574-5p with TLR7/8 in cells and the effects of inhibition of miR-574-5p-TLR7/8 signaling on lupus and lupus nephritis in a line of lupus-prone mice [PDF]
, 2017 MicroRNA(miRNA)是一种小型的非编码RNA，可以识别信使RNA的3’端非编码区进而可使得信使RNA降解抑制其翻译，调控基因的表达。有研究揭示了miRNA非传统性功能，可以与内源性的单链RNA竞争与Toll样受体结合。还有研究表明，在癌症细胞中，miR-21和miR-29a可以与小鼠mTlr7/人hTLR8结合，激活TLR信号通路促进炎症反应。然而，miRNA在自身免疫性疾病中的功能目前还知之甚少。B6.MRL-Faslpr/J小鼠是研究SLE的重要小鼠模型，伴随有自身抗体的产生 ...
张艳
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