人骨髓间充质干细胞成骨分化早期相关的长链非编码RNA的初步研究
Zhongshan Daxue xuebao. Yixue kexue ban, 2016 摘 要:【目的】 筛选与人骨髓间充质干细胞(hMSC)成骨分化早期相关的长链非编码RNA(lncRNA),分析其对于hMSC成骨分化早期的影响?【方法】 将成骨诱导分化7 d前后的hMSC作为研究对象,利用Agilent lncRNA芯片技术筛选出成骨诱导分化前后表达量具有2倍差异的lncRNA,选取其中1条表达量差异较大的lncRNA利用UCSC Genome Browser分析此lncRNA邻近蛋白编码基因?【结果】 hMSC经过成骨分化诱导7 d后具有明显成骨细胞特征;Agilent ...
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[Knockdown of long non-coding RNA MIR4697 host gene inhibits adipogenic differentiation in bone marrow mesenchymal stem cells]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2022 Shuai T, Liu J, Guo YY, Jin CY.
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LncRNA OIP5-AS1调节miR-186a-5p促进肝细胞癌凋亡及糖酵解
Zhongguo shiyan zhenduanxue目的 探讨lncRNA OIP5-AS1在肝细胞癌(HCC)中的表达及其对肿瘤发展的影响，并揭示其潜在的分子机制。方法 采用实时荧光定量PCR(RT-qPCR)分别检测LncRNA OIP5-AS1和miR-186a-5p在肝癌组织、癌旁组织的表达以及肝癌细胞系HepG2、Hep3B、Huh-7和正常肝细胞系LO2中的表达情况。Pearson相关分析评估LncRNA OIP5-AS1与miR-186a-5p表达水平的相关性。双荧光素酶报告实验检测LncRNA OIP5-AS1与miR-186a ...
臧书宁, 杨正波, 吴惧
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[Regulation of long non-coding RNA in cartilage injury of osteoarthritis]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2020 He L, Li Y, Wang G, Li C.
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[Long noncoding RNA ZEB1-AS1 aggravates cerebral ischemia/reperfusion injury in rats through the HMGB1/TLR-4 signaling axis]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Wang J +6 more
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Identification of apoptosis-related long non-coding RNAs expression profiles in patient with cervical intraepithelial neoplasia 3. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanLiu Z +5 more
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[Research progress of non-coding RNA-encoding polypeptides in primary hepatocellular carcinoma]. [PDF]
Zhonghua Gan Zang Bing Za ZhiChen DM, Yu Z, Zhang ZW, Huang JL.
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[7SK truncation at 128-179 nt suppresses embryonic stem cell proliferation in vitro by downregulating CDC6]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2021 Chen R +8 more
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Zhongshan Daxue xuebao. Yixue kexue ban铜是人体中的微量元素，与各种信号通路和肿瘤相关生物行为密切相关，但浓度超过稳态机制维持的阈值就会变得有毒，引发细胞死亡。铜死亡是一种全新的细胞死亡方式，不同于所有其他已知的细胞死亡途径，通过铜与三羧酸循环的硫辛酰化组分直接结合而发生，这导致硫辛酰化蛋白质聚集和铁硫簇蛋白丢失，引发蛋白毒性应激最终导致细胞死亡，在消化道肿瘤的发生、发展和预后中发挥作用。长链非编码RNA（lncRNA）、微小RNA（miRNA）和环状RNA（circRNA）等非编码RNA（ncRNAs ...
杜予心, 王小平
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