Results 11 to 20 of about 1,826 (102)
Effect and mechanism of microRNAs on various diabetic wound local cells microRNA对各种糖尿病创面局部细胞的作用及机制
Journal of Diabetes, Volume 15, Issue 11, Page 955-967, November 2023., 2023 Highlights For the first time, we have examined the impact of microRNA on diabetic wounds at a cellular level. We have analyzed how a particular microRNA influences different types of cells, uncovering its function and mechanism. This study furthers the discovery of the clinical potential of diverse microRNAs by evaluating their distinct effects and ...
Hongjie Li, Shengyu Jing, Hongbo Xu
wiley +1 more source
A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化
Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023 Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh +3 more
wiley +1 more source
New Phytologist, Volume 247, Issue 2, Page 504-517, July 2025.Summary Repetitive DNA is a feature of all organisms, ranging from archaea and plants to humans. DNA repeats can be seen both in coding and in noncoding regions of the genome. Due to the recurring nature of the sequences, simple DNA repeats tend to be more prone to errors during replication and repair, resulting in variability in their unit length ...
Sridevi Sureshkumar +3 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2015 微小核糖核酸（microRNA,miRNA）为非编码RNA（ncRNA）,它长度约22个核苷酸序列,与特定信使在相应的位点结合,通过改变信使RNA的稳定性来调节翻译过程,发挥调控作用,是一种重要的调控因子。多个研究发现miRNA作为ncRNA物种一个非常重要的部分[1],其存在鼠、线虫、果蝇等多个物种中,迄今为止估计人类miRNA序列编码约有1000个,预测它们可能调控约20%-30 ...
李莹 +4 more
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miR-31在人结肠癌细胞系HT-29对RhoBTB1表达的影响
Zhongguo shiyan zhenduanxue, 2013 结肠癌（colon cancer）是世界上最常见的恶性肿瘤之一,每年死亡病例居各种恶性肿瘤第三位[1]。目前为止,根治结肠癌最有效的方法还是手术切除联合化疗,对于局部肿瘤5年生存率达到93%[2]。microRNA（miRNA）是一种大小19-24个核苷酸的非编码单链小RNA分子,能够通过排序这些基因的3’段非编码区调整下游目标基因 ...
徐瑞斯, 张斌
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Zhongguo shiyan zhenduanxue, 2019 胃癌在我国占肿瘤总死亡率的第二位[1],主要依靠胃镜下对可疑肿瘤部位取活检后做病理来确诊。肿瘤标志物(CEA,CA125等)对癌症患者的筛查具有预测作用[2],但敏感性和特异性较低。近年来随着非编码RNA的发现,其在癌症组织和健康组织中存在差异性表达成为研究热点,并有望成为肿瘤的新的血清学标志物及治疗的靶点[3 ...
李金秋 +3 more
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Research progress in the role of non-coding RNAs and embryo implantation. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Liu L, Guo J, Gao W, Gao M, Ma X.
europepmc +1 more source
Zhongguo shiyan zhenduanxue特发性膜性肾病（IMN）是肾病综合征最常见的病理类型，其特征为肾小球系膜广泛增厚和电子致密物沉积。现有诊断方法具有创伤性，迫切需要开发新型无创生物标志物。本综述系统探讨了尿外泌体非编码RNA在特发性膜性肾病发病机制和诊断中的研究进展。综述重点分析了微小RNA（miRNA）、长非编码RNA（lncRNA）和环状RNA（circRNA）三类非编码RNA的分子机制。研究发现，这些尿外泌体非编码RNA在揭示IMN复杂的免疫学过程，包括免疫复合物沉积、肾小球损伤和足细胞损伤等方面具有重要意义。研究结果表明 ...
高枫 +4 more
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Zhongguo shiyan zhenduanxue, 2017 MicroRNA（miRNA）是一类非编码单链小分子RNA,由内源基因编码,长度约为20-25个核苷酸,因此又被称为微小RNA。MicroRNA能够与特定的mRNA结合,引起对应靶mRNA的降解,从而抑制其正常的翻译过程,达到基因转录后水平表达调控的目的。卵巢癌是常见的女性生殖系统恶性肿瘤之一,该病发病率和致死率极高,且起病隐匿,当患者出现典型症状时大多已发展为晚期 ...
钟莉莉, 陈雪, 赵银龙
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Zhongguo shiyan zhenduanxue, 2022 糖尿病肾病(DKD)是终末期肾衰竭的主要原因之一[1]。在DKD初期，尿白蛋白逐渐升高，将白蛋白尿作为疾病的危险分层，而随着病情进展，血肌酐逐渐升高，eGFR逐渐下降，故可将肾功能作为疾病的危险分层[2-4]。Elabela(ELA)是一种新发现的非编码RNA转录基因，经表达产生的成熟型短肽可作用apelin受体。
李延玲, 朱莹莹, 李莉, 徐锋
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