Exomic somatic variation of esophageal squamous cell carcinoma [PDF]
, 2015 目的：食管鳞状细胞癌（esophagealsquamouscellcarcinoma,ESCC）是全球常见的致死性恶性肿瘤。为进一步探讨其分子机制，我们利用全基因组外显子测序技术寻找食管鳞癌中多发的突变，包括点突变、结构变异等，并且进一步鉴定食管鳞癌中多发的单核苷酸变异（Singlenucleotidevariation,SNV）。在体细胞水平探讨食管鳞癌发生发展的分子机制。 方法：1.通过外显子测序生成并收集数据库ESCC测序数据。2.128对食管鳞癌外显子测序数据采用新一代基因序列比对方法 ...
李慧莉
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Analysis of pathological remission degree and influencing factors of radical surgery after neoadjuvant immunotherapy combined with chemotherapy in patients with locally advanced esophageal squamous cell carcinoma [PDF]
Background and purpose: Radical surgery after neoadjuvant immunotherapy combined with chemotherapy (nICT) in patients with locally advanced esophageal squamous cell carcinoma (LAESCC) has good efficacy and safety, and it can improve the patients ...
LIAO Ziyi, PENG Yang, ZENG Beilei, MA Yingying, ZENG Li, GAN Kelun, MA Daiyuan
core +1 more source
基于数据挖掘分析ATP1A1基因在肾透明细胞癌中的表达及意义 [PDF]
, 2018 目的:通过数据挖掘分析ATP1A1在肾透明细胞癌中的表达及意义。方法:通过Oncomine数据库检索关于ATP1A1的mRNA信息,采用The Human Protein Atlas分析ATP1A1蛋白在正常肾组织和肾透明细胞癌中表达情况,GEPIA网站中TCGA数据对ATP1A1低表达的肾透明细胞癌患者进行生存分析,Meth HC数据库分析ATP1A1甲基化水平和蛋白相互作用,利用String-DB数据分析ATP1A1与上下游蛋白的相互作用。结果:肾透明细胞癌(Clear cell Renal ...
崔强 +6 more
core +1 more source
The expression and clinical significance of SATB2 in Esophageal Squamous Cell Carcinoma [PDF]
, 2015 摘要 研究目的：食管癌在中国是一种高发的消化系统恶性肿瘤。由于解剖位置深、临床症状隐匿、早期症状不明显、易以多种路径转移、高位癌手术残留、术后容易复发以及放化疗不敏感等特点，食管癌预后较差。因此，进一步深入研究食管癌发生发展、侵袭转移以及预后评估因素的内在机制具有重要的意义。SATB1是富含AT序列结合蛋白的特殊家庭成员之一，已被证明影响众多肿瘤致瘤性的过程。SATB2与肿瘤的关系密切一直是研究的关注点，然而，其在食管鳞状细胞癌组织中的作用不清楚。本论文以食管鳞癌为研究对象，以SATB2为切入点 ...
李宁
core
Correlation of SOAT1 and TREM1 expression with clinicopathological features and prognosis in esophageal squamous cell carcinoma [PDF]
"Objective To investigate the mRNA expression levels of sterol O⁃acyltransferase 1（SOAT1）and triggering receptor expressed on myeloid cells 1（TREM1）in esophageal squamous cell carcinoma（ESCC）tissues and analyze their associations with clinical ...
LU Yang，GAO Chao
core +2 more sources
沉默EC9706细胞NS基因对裸鼠移植瘤组织中EGF、EGFR基因表达的影响 [PDF]
, 2011 目的建立裸鼠食管癌移植瘤模型,探讨由RNAi诱导的EC9706细胞核干细胞因子(nucleostemin,NS)基因沉默对裸鼠移植瘤组织中EGF、EGFR基因表达的影响。方法裸鼠15只,采用STATA 8.0编制随机化分组程序,均分为3组,分别皮下注入pRNAT-U6.1-siNS2转染的EC9706细胞(siRNA干预组),pRNAT-U6.1-siC转染的EC9706细胞(无关siRNA对照组)以及正常EC9706细胞(空白对照组),接种5周,观察移植瘤生长情况 ...
关文池 +4 more
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Expression and biological role of Matrix metalloproteinases 16 in esophagus squamous cell carcinoma [PDF]
, 2013 背景及目的 食管癌是世界第六大癌症死因，临床上多数患者就诊时已经进入中晚期，手术效果差，五年生存率仅徘徊在10%～20%。其治疗效果不佳的主要原因是肿瘤的侵袭和转移。基质金属蛋白酶是肿瘤侵袭和转移过程中周围基质降解和重塑得重要酶，但MMP抑制剂在多种癌症患者身上进行实验时，这种药物无法减缓肿瘤生长，有时甚至加快肿瘤生长，这提示并非所有MMP均为原癌基因。基质金属蛋白酶-16在多种肿瘤组织中有较高的表达，但在食管癌中的表达及与食管癌侵袭和转移关系的研究目前尚未有报道。我们检测食管癌组织标本MMP ...
吴秋丽
core
miR-1-3p Inhibits Malignant Biological Behavior of Human Esophageal Squamous Cell Carcinoma Cells by Regulating STC2 [PDF]
ObjectiveTo explore the effect of miR-1-3p on the malignant biological behavior of human esophageal squamous cell carcinoma cells and the potential mechanisms.
Changlin GAO +6 more
core +1 more source
Research progress in the anti-cancer activity and related mechanisms of arenobufagin [PDF]
Toad venom is an active extract of toad, which is processed by distilling or drying at high temperature the venom secreted from the skin glands and ear-side glands of Toad Chinensis.
BAI Wenhui, SHEN Shukun, WU Yingli
core +1 more source
Clinical Significance of WISP-1 and VEGF-A Expression Levels in Elderly Patients with Esophageal Squamous Cell Carcinoma [PDF]
ObjectiveTo investigate the clinical value of WNT1 inducible signaling pathway protein 1 (WISP-1) and vascular endothelial growth factor-A (VEGF-A) as novel molecular markers of esophageal squamous cell carcinoma (ESCC) in elderly patients ...
Chenlu LI, Junxing HUANG
core +1 more source