Results 31 to 40 of about 795 (119)
Research progress in the expression of versican in malignant tumors and its biological roles [PDF]
Malignant tumors pose a serious threat to human health and are one of the main causes of human death worldwide. In order to further improve the therapeutic outcomes of malignant tumors and prolong patients' survival time, clarifying the pathogenesis of ...
FAN Zhisong +4 more
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CDC20 facilitates the proliferation of esophageal carcinoma cell by stabilizing NLRP3 expression [PDF]
Background and purpose: Esophageal carcinoma (ESCA) is one of the malignant tumors with high mortality rate, and the underlying mechanism of its development is largely unknown.
GUAN Ruirui, HAO Qian, ZHANG Yaqi, SUN Qinggang, CHEN Yitian, LI Xiumin, ZHOU Xiang, HAN Tao
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Esophageal cancer complicated with extensive cervical lymph node metastasis： a case report [PDF]
Cervical tumors may occur in a variety of benign and malignant tumors. It is difficult to make a correct diagnosis in the absence of other systemic symptoms and pathological biopsy， which is likely to delay the optimal treatment opportunity.
Wang Qianqian, Zou Kongzhen, Zhang Xiaoyu, Lin Pingping
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, 2004 我国是食管癌的高发地区 ,食管癌的死亡率占全国肿瘤死亡第二位 ,早发现早治疗是提高食管癌患者生存率的关键。食管癌相关基因甲基化与食管癌的发生、发展密切相关 ,基因的多态性与食管癌易感性相关。本文就近年来国内报道较少的有关食管癌基因甲基化 ...
刘莉莉, 陈亮
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Zhongguo shiyan zhenduanxue, 2015 食管癌是胸外科主要的常见病之一,其中颈段食管癌是食管外科领域中比较重要的课题,颈段食管癌的手术比中下段食管癌手术更为复杂、创伤大,预后差,术后生存时间短,因此该课题的研究更为重要,手术方式也需进一步改进,术后的放化疗效果也不理想。1临床资料1.1患者资料男56岁,因进食哽咽感半年,颈部肿痛半个月入院,患者因进食哽咽感半年于当地医院行食道镜检查并取病理报:食管鳞状细胞癌 ...
冯永刚, 李晓丽, 韩春山
doaj
KRT23 promotes the proliferation of liver cancer by activating AKT signaling pathway [PDF]
Objective To investigate the effect of high keratin 23 （KRT23） expression promoting cell proliferation on liver cancer. Methods The expression of KRT23 in liver cancer was analyzed by bioinformatics.
Liang Xinghua, Liu Foqiu, Yan Rong, Hu Juan
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Zhongguo shiyan zhenduanxue, 2018 研究发现程序性死亡因子-1(PD-1)、程序性死亡1-配体(PD-L1)在多种肿瘤细胞和肿瘤组织中均有表达,如黑色素瘤、非小细胞肺癌、肾母细胞瘤等,肿瘤组织中过度表达的PD-L1通过与PD-1结合下调抗肿瘤免疫反应[1,2]。目前已有多种免疫药物在临床上应用于多种恶性肿瘤,如pembrolizumab是一种高亲和力的结合PD-1的人源化IgG4-kappa抗体用于治疗晚期黑色素瘤,muvolumab用于治疗鳞状细胞肺癌,并取得美国食品药品管理局(FDA)通过及认证[3 ...
王耿杰 +3 more
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The expression of TNFAIP8 in gastric cancer and its clinical significance [PDF]
, 2012 目的通过检测胃癌组织中肿瘤坏死因子α诱导蛋白8(TnfAIP8)的表达,探讨其与胃癌临床病理参数的关系及与胃癌发生发展的关系,揭示胃癌的发病机制。方法采用免疫组化SP法,检测50例胃癌以及50例正常胃粘膜中TnfAIP8的表达。结果 50例正常胃粘膜组织中TnfAIP8无表达,而在50例胃癌组织中TnfAIP8阳性表达13例,TnfAIP8阳性率为26%。低分化胃癌组TnfAIP8阳性表达率明显高于中分化腺癌组 ...
刘忠臣 +5 more
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, 2018 环状RNA(circular RNA,circ RNA),作为非编码RNA(non-coding RNA)的重要成员,广泛存在于包括人类在内的多种原核及真核生物体内,对生命活动具有重要的调控作用,已成为非编码RNA研究领域的热点。与线性RNA相比,circ RNA呈共价闭合环状结构,具有结构稳定、序列保守、组织特异性、时空特异性等特点,在包括消化道肿瘤在内的多种疾病中发挥重要作用。circ RNA可通过竞争性吸附mi RNA、调控基因表达、参与蛋白质翻译等多种途径,参与肿瘤的发生发展,在肿瘤早期诊断 ...
施颖, 李金莹, 黄卫
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Zhongguo shiyan zhenduanxue, 2016 鳞状细胞癌伴小细胞神经内分泌癌最常见发生于肺,也可发生在食管、纵膈、宫颈等部位,但发生在胸壁的罕见。现报道如下。1临床资料患者,女,76岁,7年前发现胸壁一肿物,鸡蛋黄大小,无疼痛,不发热,未经系统治疗,近几个月来肿物逐渐增大并伴有表皮破溃,自行涂抹强力碘,未见好转,就诊于我院,查体 ...
祝红晶, 李彤, 黄文慧, 杨春荣
doaj