ＴＧＦ－β１／Ｓｍａｄ７信号通路在哈萨克族食管癌上皮间质转化中的作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2015 【目的】 探讨ＴＧＦ－β１／Ｓｍａｄ７信号通路在哈萨克族食管鳞癌上皮间质转化（ＥＭＴ）中的作用及其机制。【方法】 运用免疫组织化学方法检测５０例哈萨克族食管鳞癌组织及远端对应癌旁组织中ＴＧＦ－β１与Ｓｍａｄ７蛋白的表达。进一步在细胞水平，针对食管鳞癌细胞系Ｅｃ９７０６，基于ＲＮＡ干扰技术，使用ＬｉｐｏｆｅｃｔａｍｉｎｅＴＭ ２０００试剂转染ＴＧＦ－β１ ｓｉＲＮＡ。采用ｑＲＴ－ＰＣＲ技术检测ＴＧＦ－β１及Ｓｍａｄ７ ｍＲＮＡ表达水平；Ｗｅｓｔｅｒｎ ｂｌｏｔ 技术检测转染后各组ＴＧＦ－β１ ...
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Analysis of Gut Flora in a Mouse Model of Esophageal Squamous Cell Carcinoma in Situ [PDF]
, 2022 BackgroundWith the application and development of high-throughput sequencing-based approaches for gut flora analysis, increasing studies have confirmed that gut flora is closely related to the development of various cancers.
ZHANG Yushuang, YU Fuyang, WU Zhongbing, WANG Yiran, LI Jing
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Preliminary study on involving field irradiation radiotherapy in neoadjuvant chemoradiotherapy for esophageal cancer [PDF]
, 2023 Background and purpose: The standard treatment for patients with locally advanced esophageal cancer is neoadjuvant chemoradiotherapy (NCRT) plus radical resection.
DONG Xiaohuan, LIU Jun, LI Hongxuan, CHENG Yan, LI Yue, YU Wen, CAI Xuwei, FU Xiaolong
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Esophageal squamous cell carcinoma : opportunities for prevention [PDF]
, 2020 Esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype of esophageal cancer, a highly fatal malignant neoplasm. Most ESCC patients are diagnosed at a late stage when tumors are unresectable or have metastasized.
Wang, Qiaoli
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Analysis of influencing factors of adaptation level in patients with permanent enterostomy [PDF]
, 2023 Objective·To investigate the level of stoma adaptation in patients with permanent enterostomy and its influencing factors.Methods·In this cross-sectional study, 260 patients with permanent enterostomy from North Campus in Hongkou and South ...
FANG Fang +3 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2014 摘 要： 【目的】 探讨颈部淋巴结的转移侧数对非手术胸段食管鳞癌预后的影响及胸段食管鳞癌放化疗预后因素。 【方法】 将３９５例接受同期放化疗治疗的食管鳞癌患者分为五组：Ａ组，无区域淋巴结转移及远处转移；Ｂ组，伴有区域淋巴结转移；Ｃ组，单侧颈部淋巴结转移不伴有其他远处转移；Ｄ组，双侧颈部淋巴结转移不伴有其他远处转移；Ｅ组，其他远处转移。研究终点是总生存率及无进展生存率，并对预后因素进行单因素和多因素分析。【结果】Ａ、Ｂ、Ｃ、Ｄ、Ｅ组的３年ＯＳ分别为 ４７．６％、４６．４％、３３．５％、１４．８％、５．７％（
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RSRC1 inhibits the proliferation and metastasis of ESCC by targeting PTEN/PI3K/AKT pathway [PDF]
, 2023 Objective To explore the role of arginine-and serine-rich coiled coil 1（RSRC1） in the proliferation and metastasis of esophageal squamous cell carcinoma（ESCC）. Methods The expression of PTEN in ESCC was detected by biogenic analysis.
Zhou Jiatian, Shang Guansheng, Zhang Cong, Jiang Dexiong, Yuan Dongdong, Tang Dengyao, Zhou Jiang
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Chinese expert consensus on clinical application of recombinant oncolytic adenovirus in the treatment of malignant tumors [PDF]
, 2023 Treatment using oncolytic virus as a new tumor immunologic agent has made continuous breakthroughs in basic and clinical research of tumor in recent years, and it is expected to play an important role in cancer immunotherapy in the future.
Expert Committee on Immunotherapy of Chinese Society of Clinical Oncology , Professional Committee on Cancer Biotherapy of Shanghai Anticancer Association
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Research on T Lymphocyte Subsets and NK Cells Activity in Peripheral Blood of Hypopharyngeal Squamous Cell Carcinoma [PDF]
, 2017 目的:分析下咽鳞状细胞癌患者外周血T淋巴细胞亚群和NK细胞活性情况,旨在为相关研究工作提供参考资料。方法:择取2011年6月-2016年5月本院收治的95例下咽鳞状细胞癌病患为病例组,另取此期间内来本院接受健康检查的72例志愿者为正常组。使用流式细胞仪对病患开展相关检查,分析病例组与正常组的淋巴细胞亚群、NK活性情况以及不同临床分期的下咽癌病患外周血T淋巴细胞亚群以及NK细胞活性之间的关系。结果:与正常组相比,病例组的NK细胞、总B淋巴细胞、总T淋巴细胞、辅助/抑制T细胞、辅助T细胞偏低(P0.05 ...
刘存山 +7 more
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食管癌组织中ADAMTS1、ADAMTS18基因mRNA的表达及其意义
Zhongguo shiyan zhenduanxue, 2021 目的探讨ADAMTS1和ADAMTS18基因在食管鳞状细胞癌组织中的表达及其与食管鳞状细胞癌临床病理特征的关系。方法应用半定量逆转录聚合酶链反应(RT-PCR)方法分别检测70例食管鳞状细胞癌组织及癌旁正常组织中ADAMTS1、ADAMTS18的mRNA表达,并分析基因表达与临床病理资料之间的关系。结果食管鳞状细胞癌组织中ADAMTS1、ADAMTS18基因的mRNA表达水平显著低于相应的癌旁正常组织(P0.05),ADAMTS1基因mRNA在有淋巴结转移组的表达量高于无淋巴结转移组(P0.05 ...
尹蕾 +5 more
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