FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Comment on “Solving the riddle of the bright mismatches: Labeling and effective binding in oligonucleotide arrays” [PDF]
, 2006 Enrico Carlon +3 more
openalex +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Semantic Segmentation of highly class imbalanced fully labelled 3D\n volumetric biomedical images and unsupervised Domain Adaptation of the\n pre-trained Segmentation Network to segment another fully unlabelled\n Biomedical 3D Image stack [PDF]
, 2020 Shreya Roy, Anirban Chakraborty
openalex +1 more source
Efectos de los atributos de la hembra de ñandú (Rhea americana) sobre la viabilidad del huevo [PDF]
, 2019 We conducted a study throughout a breeding season in a captive-bred population of Greater rheas (Rhea americana) to evaluate the association between egg viability and the female´s body weight and age.
Bazzano, Gisela del Valle +3 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Revue des Sciences Humaines, 2017 ‘Pseudo-native speaker’ is the term given to a foreign language learner who has reached a high level of proficiency. Such level of proficiency is characterised by the mastery of grammar, vocabulary, and pronunciation.
Mohamed Akram Arabet
doaj
Collinear order in a frustrated three-dimensional spin-$\frac12$ antiferromagnet Li$_2$CuW$_2$O$_8$
, 2015 Magnetic frustration in three dimensions (3D) manifests itself in the spin-$\frac12$ insulator Li$_2$CuW$_2$O$_8$. Density-functional band-structure calculations reveal a peculiar spin lattice built of triangular planes with frustrated interplane ...
Kasinathan, D. +6 more
core +1 more source