Results 131 to 140 of about 284,135,228 (316)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On the Placenta of a Monkey

open access: yes, 1877
Volume: 29Start Page: 194End Page ...
Chapman, Harold C.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The Fur Trade and the Fur Supply

open access: yes, 1922
Volume: 3Start Page: 1End Page:
Ashbrook, F. G.
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

تلقي رثاء ابن العسَّال لطليطلة بين التفهم والإنكار

open access: yesRevue des Sciences Humaines, 2017
تعدّ نظرية التلقي من أهمّ النظريات التي اهتمت بالمتلقّي، ودوره الداعم لعملية الإبداع في الشِّعر بخاصّة. ومن بين النّصوص الشِّعرية التي حظيت باهتمام الدارسين والنقّاد أبيات ابن العسّال التي نظمها في رثاء طليطلة، فقد كانت في مستوى البرقية المزلزلة وجّهها ...
مليكة حيمر   +1 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Stone\u27s \u27The Birds of New Jersey\u27

open access: yes, 1910
Volume: 27Start Page: 95End Page ...
Stone, Witmer.
core   +1 more source

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