Results 51 to 60 of about 858,524 (249)

Modelling intentions to provide smoking cessation support among mental health professionals in the Netherlands

Tobacco Induced Diseases, 2016
Introduction Tobacco use prevalence is elevated among people with mental illnesses, leading to elevated rates of premature smoking-related mortality.
Matthijs Blankers, Renate Buisman, Petra Hopman, Ronald van Gool, Margriet van Laar   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Agricultural practices can threaten soil resilience through changing feedback loops

npj Sustainable Agriculture
Soil has supported terrestrial food production for millennia; however, agricultural intensification may affect its resilience. Using a systems-thinking approach, we reviewed the impacts of conventional-agriculture practices on soil resilience and ...
Alison M. Carswell, Simon Willcock, Martin S. A. Blackwell, Hari Ram Upadhayay, Paul Harris, Graham McAuliffe, Andrew L. Neal, M. Jordana Rivero, Laura M. Cardenas, Stephan M. Haefele, Andrew P. Whitmore, John A. Dearing, Fusuo Zhang, Mark Farrell, Marijn Bauters, Pascal Boeckx, Yuri Jacques A. B. da Silva, Kwame Agyei Frimpong, Adrian L. Collins   +18 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Senior Digital Up-Skilling – Erasmus Plus Programme Project Dial Case Study

Economics and Culture, 2019
Research purpose. With the current and progressive ageing of the population globally, in Europe over the past three decades, the urgency of creating a specific theoretical and educational model for older adults, in which the professional purpose is not ...
Cirule Iveta, Balta Monta, Komarova Irena, Gudele Ina   +3 more
doaj   +1 more source

Smart Audio Sensors in the Internet of Things Edge for Anomaly Detection

IEEE Access, 2018
Everyday objects are becoming smart enough to directly connect to other nearby and remote objects and systems. These objects increasingly interact with machine learning applications that perform feature extraction and model inference in the cloud ...
Mattia Antonini, Massimo Vecchio, Fabio Antonelli, Pietro Ducange, Charith Perera   +4 more
doaj   +1 more source

Diffusion nets

Applied and Computational Harmonic Analysis, 2019
Non-linear manifold learning enables high-dimensional data analysis, but requires out-of-sample-extension methods to process new data points. In this paper, we propose a manifold learning algorithm based on deep learning to create an encoder, which maps a high-dimensional dataset and its low-dimensional embedding, and a decoder, which takes the ...
Mishne, Gal, Shaham, Uri, Cloninger, Alexander, Cohen, Israel   +3 more
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Design of a 130 MW Axial Turbine Operating with a Supercritical Carbon Dioxide Mixture for the SCARABEUS Project

International Journal of Turbomachinery, Propulsion and Power
Supercritical carbon dioxide (sCO2) can be mixed with dopants such as titanium tetrachloride (TiCl4), hexafluoro-benzene (C6F6), and sulphur dioxide (SO2) to raise the critical temperature of the working fluid, allowing it to condense at ambient ...
Abdelrahman S. Abdeldayem, Salma I. Salah, Omar A. Aqel, Martin T. White, Abdulnaser I. Sayma   +4 more
doaj   +1 more source