Results 171 to 180 of about 10,198,141 (356)

The 100 000 Genomes Project: bringing whole genome sequencing to the NHS

open access: yesBritish medical journal, 2018
C. Turnbull   +28 more
semanticscholar   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Forming a Hypothesis [PDF]

open access: yes, 2007
Provides pedagogical insight concerning the skill of hypothesizing The resource being annotated is: http://www.dlese.org/dds/catalog_DLESE-000-000-007-442 ...
Lamont-Doherty Earth Observatory, Columbia University
core  

Muon Decay in Nuclear Emulsion at 25 000 Gauss [PDF]

open access: bronze, 1960
G. R. Lynch, J. Orear, S. Rosendorff
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Developing Effective K-16 Geoscience Partnerships [PDF]

open access: yes, 2003
This article describes the benefits of research partnerships to scientists, students, and teachers. There is growing awareness that the way science is experienced in the K-16 classroom deviates greatly from the experiences of practicing researchers ...
Paul Harnik, Robert Ross
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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