Results 51 to 60 of about 663,911 (245)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Interpretation of cancer death burden data from disease surveillance sites in China from 2005 to 2020 [PDF]

open access: yesZhenduanxue lilun yu shijian
In December 2023, the Chinese Center for Disease Control and Prevention published National and subnational trends in cancer burden in China, 2005-2020: an analysis of national mortality surveillance data.on Lancet Public Health, covering the mortality ...
ZHANG Xin, ZHENG Ying
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

DIE STIGTING EN WERKSAAMHEDE VAN DIE "NEDERLANDSCH BIJSTANDSFONDS VOOR ZUID-AFRIKA" (1900-1903)

open access: yesScientia Militaria, 2012
Die Tweede Anglo-Boereoorlog (1899 - 1902) het byna drie jaor gewoed. Die Britsemilitêre verliese is, afgerond, op ongeveer 7 000 gesneuweldes en 20 000 gewondes geskat, Die republikeinse militêre verliese word op ongeveer 4 000 gesneuweldes bereken. Die
Jan Ploeger
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Calculo de tanque de PRFV de 200 000 litros de capacidad. // 200 000 liters capacity PRFV tank calculation.

open access: yesIngeniería Mecánica, 2002
La tarea que se acomete es el cálculo a resistencia y rigidez de un tanque para el almacenamiento de agua, de 200 000 litrosde capacidad, construido de plástico reforzado con fibras de vidrio, PRFV. El mismo es cilíndrico vertical, de 8 metros dediámetro
J. García de la Figal Costales   +1 more
doaj  

Disease Burden of Osteoarthritis in the World, China, and Regions with Different Socio-demographic Index from 1990 to 2021 [PDF]

open access: yesZhongguo quanke yixue
Background Osteoarthritis (OA) seriously endangers the physical and mental health of patients. Currently, systematic studies on the disease burden of OA are limited.
CHEN Xingchao, GAO Zhenhua, XU Shenggang, ZOU Yonggang, QIAN Jun, WEI Jiantong
doaj   +1 more source

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