Results 1 to 10 of about 455,273 (283)

Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia

Frontiers in Immunology, 2022
BackgroundIschemic stroke is one of the leading causes of human death and disability. Brain edema and peri-infarct astrocyte reactivity are crucial pathological changes, both involving aquaporin-4 (AQP4).
Chengfeng Sun, Luyi Lin, Lekang Yin, Xiaozhu Hao, Jiaqi Tian, Xiaoxue Zhang, Yan Ren, Chanchan Li, Yanmei Yang   +8 more
doaj   +2 more sources

Pharmaceutical Cocrystal Development of TAK-020 with Enhanced Oral Absorption

Crystals, 2020
The objective of this study was to improve the solubility of poorly water-soluble drugs by pharmaceutical cocrystal engineering techniques and select the best pharmaceutical forms with high solubility and solubilized formulations for progress from the ...
Kouya Kimoto, Mitsuo Yamamoto, Masatoshi Karashima, Miyuki Hohokabe, Junpei Takeda, Katsuhiko Yamamoto, Yukihiro Ikeda   +6 more
doaj   +2 more sources

Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury

Molecular Pain, 2018
Extracellular regulated protein kinase (ERK) pathway activation in astrocytes and neurons has been reported to be critical for neuropathic pain development after chronic constriction injury.
Liang Zhao, Dan Li, Nan Liu, Lu Liu, Zhuo Zhang, Chao Gao, Hitoshi Kawano, Fang-Yuan Zhou, Hong-Peng Li   +8 more
doaj   +2 more sources

Optical coherence tomography guided targeted non-viral optical delivery of opsin-encoding genes into the retina [PDF]

Frontiers in Pharmacology
IntroductionRetinal degenerative diseases cause progressive photoreceptor loss while leaving populations of inner retinal neurons available for optogenetic intervention.
Sanghoon Kim, Michael Carlson, Subrata Batabyal, Adnan Dibas, Samarendra Mohanty, Samarendra Mohanty   +5 more
doaj   +2 more sources

Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti–Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial

Journal of Clinical Oncology, 2023
PURPOSE Nivolumab and relatlimab activity in advanced melanoma with prior progression on anti–programmed death-1/programmed death ligand 1 (PD-(L)1)-containing regimens is under investigation.
P. Ascierto, E. Lipson, R. Dummer, J. Larkin, G. Long, R. Sanborn, V. Chiarion-Sileni, B. Dréno, S. Dalle, D. Schadendorf, M. Callahan, M. Nyakas, V. Atkinson, C. Gomez-Roca, N. Yamazaki, H. Tawbi, Naomey Sarkis, D. Warad, S. Dolfi, P. Mitra, S. Suryawanshi, J. Grob   +21 more
semanticscholar   +1 more source

TGN-020 Alleviate Inflammation and Apoptosis After Cerebral Ischemia–Reperfusion Injury in Mice Through Glymphatic and ERK1/2 Signaling Pathway

Molecular Neurobiology, 2023
Post-stroke acute inhibition of aquaporin 4 (AQP4) is known to exacerbate inflammation and apoptosis, yet the underlying mechanisms are not fully understood.
Xiaohong Li, Zhuoxi Xie, Qiang Zhou, Xiaoli Tan, Weiting Meng, Yeyu Pang, Li-Zhen Huang, Zhi-Hao Ding, Yuanhong Hu, Ruhua Li, Gui-Lan Huang, Hao Li   +11 more
semanticscholar   +1 more source

ANALISIS PEMAHAMAN GURU TERHADAP GAYA BELAJAR SISWA DI SDN 020 RIDAN PERMAI

Jurnal review pendidikan dasar. Jurnal kajian pendidikan dan hasil penelitian, 2022
This research was motivated by the importance of teacher's role in understanding students’ characteristics such as learning styles. This research was aimed to describe the teachers' understanding on students’ learning styles, learning profiles, services ...
Dina Hafizha, Rizki Ananda, Iis Aprinawati   +2 more
semanticscholar   +1 more source

A Novel Methodology for Developing Troubleshooting Chatbots Applied to ATM Technical Maintenance Support

Applied Sciences, 2023
The banking industry has been employing artificial intelligence (AI) technologies to enhance the quality of its services. More recently, AI algorithms, such as natural language understanding (NLU), have been integrated into chatbots to improve banking ...
Nádila Azevedo, Gustavo Aquino, Leonardo Nascimento, Leonardo Camelo, Thiago Figueira, Joel Oliveira, Ingrid Figueiredo, André Printes, Israel Torné, Carlos Figueiredo   +9 more
doaj   +1 more source

The Novel IGF-1R Inhibitor PB-020 Acts Synergistically with Anti-PD-1 and Mebendazole against Colorectal Cancer

Cancers, 2022
Simple Summary Colorectal cancer (CRC) is generally diagnosed at an advanced stage, when chemo- and targeted therapies can only achieve a limited increase in overall survival for these patients.
Bo Kang, Xiao-Bing Zhang, Weibing Wang, Shi-Qi She, Wenjie Chen, Cheng Chen, Yi-Sha Wang, Xiao-Yun Pan, Ouyuan Xu, Ying-Jie Wang   +9 more
semanticscholar   +1 more source

A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects

Clinical and Translational Science, 2021
Bruton’s tyrosine kinase (BTK) is a target for treatment of hematologic malignancies and autoimmune diseases. TAK‐020 is a highly selective covalent BTK inhibitor that inhibits both B cell receptor and fragment crystallizable receptor signaling.
Ehsanollah Esfandiari, Mary Chen, Glennda Smithson, Derek Blair, Helene Faessel, John Wagner, Lachy Mclean, Eric R. Fedyk   +7 more
doaj   +1 more source