Results 1 to 10 of about 332,337 (302)
GX15-070 enhances niraparib efficacy in ovarian cancer by promoting a shift in Mcl1-mediated DNA repair pathway from HR to NHEJ [PDF]
Journal of Translational MedicineBackground PARP inhibitor (PARPi) maintenance therapy significantly extends progression-free survival of patients with homologous recombination repair deficiency (HRD) or BRCA mutations in ovarian cancer.
Jia-Jia Sheng +7 more
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Structural basis for human TRPC5 channel inhibition by two distinct inhibitors
eLife, 2021 TRPC5 channel is a nonselective cation channel that participates in diverse physiological processes. TRPC5 inhibitors show promise in the treatment of anxiety disorder, depression, and kidney disease.
Kangcheng Song +6 more
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Microorganisms, 2022 The oral cavity harbors hundreds of microorganisms that may be uncontrolled and provoke several diseases. In this sense, periodontitis is a complex multifactorial disease with an essential microbial component in its etiology.
Luciene Cristina Figueiredo +7 more
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Is Germany a “digital outsider”?
RUDN Journal of Studies in Literature and Journalism, 2020 The article is devoted to digitalization in Germany, taking into account the historical context. The scientific novelty and relevance of the study lies in the fact that the German digital media history is examined against the background of the ...
Elena M. Gaponova
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Zhongguo shuxue zazhi, 2023 Objective To study the application effect of electrochemiluminescence immunoassay (ECLIA) in the screening of human T-lymphotropic virus (HTLV) in blood donors, explore the correlation between COI and confirmed result by western blot (WB), so as to ...
Zhengang SHAN +7 more
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Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. [PDF]
PLoS ONE, 2018 Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel canonical subfamily (TRPC) members 4 and 5 are non-selective cation channels highly expressed in ...
Stefan Just +23 more
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How Did COVID-19 Impact the Antimicrobial Consumption and Bacterial Resistance Profiles in Brazil?
Antibiotics, 2023 The indiscriminate use of antibiotics has favored the selective pressure of multidrug resistance among microorganisms. This research evaluated the pattern of antibiotic prescriptions among the Brazilian population between January 2018 and December 2021 ...
Natália Cassago Marcos Massarine +7 more
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Diagnostics, 2022 In the diagnosis of olfactory neuroblastoma (ONB), the presence of S-100–positive sustentacular cells surrounding the tumor is important; however, these are also present in normal nasal sinus epithelium. Although ONB often has a different final diagnosis,
Kosuke Takabayashi +3 more
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