Results 21 to 30 of about 12,888 (222)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Residents’ support in major local events: Leeds Pride [PDF]

open access: yes, 2016
This article examines the extent to which community participation and perceived impacts have an influence on residents’ support of major events, more specifically, the Leeds Pride celebration. The research examines the perspectives of 400 Leeds permanent
Pappas, Nikolaos
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Identifying and Prioritizing Creative Tourism Attractions in the Life of the Nomads from the Guest-Host Perspective (Case study: Bakhtiari Tribe, Khuzestan Province)

open access: yesگردشگری و اوقات فراغت
This study aims to identify and prioritize creative tourism attractions in nomadic life from a host-guest perspective. The research method is descriptive-analytical and the statistical population includes tour guides and nomadic tourism activists.
Mehrnoosh bastenega, Anahita Azarbod
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Portmerion, Proportion and Perspective [PDF]

open access: yes, 2012
The holiday village of Portmerion was created by Bertram Clough Williams-Ellis (1883 1978) over a period of fifty-one years, starting in 1926. It was grade II listed in 1971.
Messer, Sebastian, Ellis, Francis
core  

Blockchain-Audited Federated Learning: Securing Data and Model Updates With On-Chain Provenance

open access: yesIET Software
We present a permissioned blockchain–audited federated learning (FL) framework that strengthens data provenance and model-update integrity. Our contribution is primarily engineering and architectural: a modular two-channel design (provenance vs.
Seid Mehammed   +5 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Discursive and Non-Discursive Design Processes [PDF]

open access: yes, 2007
This research study investigates the hypothesis that Space Syntax plays a role in enhancing architectural design as a knowledge-based process by bringing the nondiscursive design process onto a discursive level, and by making explicit the logic of ...
Al-Sayed, K.
core  

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