Results 41 to 50 of about 12,888 (222)
Software architecture visualisation [PDF]
, 2004 Tracing the history of software engineering reveals a series of abstractions. In early days, software engineers would construct software using machine code.
Hatch, Andrew
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Architectural Design Quality in Local Authority Private Finance Initiative Sheltered Housing Projects: The Development of an Evaluation Tool [PDF]
, 2014 Ever since the 1990s, when the Private Finance Initiative (PFI) was developed as the primary method for delivering major public-sector capital projects in the UK, it has been severely criticised for the lack of design quality in the buildings that it ...
Sharma, Monika
core
From Principles to Details: Integrated Framework for Architecture Modelling of Large Scale Software Systems [PDF]
, 2013 There exist numerous models of software architecture (box models, ADL’s, UML, architectural decisions), architecture modelling frameworks (views, enterprise architecture frameworks) and even standards recommending practice for the architectural ...
Szymon Kijas +5 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Improving construction design : The lean thinking paradigm [PDF]
, 1999 A study has been conducted into improving construction design through the application of the lean thinking paradigm. Its objective was to identify the issues relating to design efficiency and how a lean thinking approach might address these issues ...
Morris, J., Morris, Jonathan
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source