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1,2,4-Triazole: A Privileged Scaffold for the Development of Potent Antifungal Agents - A Brief Review

Current Topics in Medicinal Chemistry, 2020
Over the past decades, a tremendous rise in invasive fungal infection diseases attributed to the yeast Candida albicans in immunocompromised individuals poses a seriously challenging issue.
C. Tratrat
semanticscholar   +1 more source

Synthesis, Characterization, and Antimicrobial Evaluation of Some New 1,4-Dihydropyridines-1,2,4-Triazole Hybrid Compounds

Polycyclic aromatic compounds (Print), 2020
Many 1,4-dihydropyridines hybrid with 1,2,4-triazole 4a-l were synthesized by the reaction of 5,5′-(2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-diyl)bis(4-amino-4H-1,2,4-triazole-3-thiol) (2) with various substituted aldehydes.
Sobhi M. Gomha   +5 more
semanticscholar   +1 more source

1,2,4‐Triazole hybrids with potential antibacterial activity against methicillin‐resistant Staphylococcus aureus

Archiv der Pharmazie, 2020
Methicillin‐resistant Staphylococcus aureus (MRSA) has developed numerous mechanisms of virulence and strategies to evade the human immune system, and it can be transmitted between humans, animals, and the environment. Thus, MRSA is an important cause of
Xuemei Ge, Zhi Xu
semanticscholar   +1 more source

ChemInform Abstract: SYNTHESIS AND ANTIVIRAL ACTIVITY OF 1,2,4‐TRIAZOLE‐3‐THIOCARBOXAMIDE AND 1,2,4‐TRIAZOLE‐3‐CARBOXAMIDINE RIBONUCLEOSIDES

Chemischer Informationsdienst, 1973
Abstract1‐β‐D‐Ribofuranosyl‐1,2,4‐triazol‐3‐carbonsäureamid (IVa) besitzt antivirale Aktivität. Deshalb werden (IVa) und ähnliche Verbindungen hergestellt, indem zunächst durch Kondensation zwischen dem Nitril (I) und dem Zuckeracetat (II) das Kondensat (III) hergestellt wird.
Joseph T. Witkowski   +3 more
openaire   +4 more sources

Structure and IR spectroscopic properties of complexes of 1,2,4-triazole and 3-amino-1,2,4-triazole with dinitrogen isolated in solid argon

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023
Complexes of 1,2,4-triazole (TR) and 3-amino-1,2,4-triazole (AT) with N2 were studied computationally employing MP2 and B3LYPD3 methods and experimentally by FTIR matrix isolation technique. The results show that both triazoles interact specifically with dinitrogen in several different ways.
K. Mucha   +3 more
openaire   +2 more sources

Regiospecific Synthesis of 1-Substituted 1,2,4-Triazoles by Reaction of 1,2,4-Triazole with Aldehydes

Chemistry Letters, 1990
Abstract The reactions of 1,2,4-triazole with aldehydes and various acid chlorides provide a convenient, regiospecific route to 1-substituted 1,2,4-triazoles.
I. J. Ellison   +4 more
openaire   +3 more sources

1,2,4-Triazoles

2008
This chapter provides a critical update on developments in the chemistry of 1,2,4-triazoles over the last decade. 1,2,4-Triazoles have remained the topic of much research, primarily due to their ubiquitous presence in many pharmaceutical agents and, more recently, in other functional materials with uses in engineering as corrosion inhibitors and in ...
N. Jennings, Anthony D.M. Curtis
openaire   +2 more sources

Syntheses of substituted‐1,2,4‐triazoles

Journal of Heterocyclic Chemistry, 1992
AbstractStarting from the readily available 3‐phenylpropionitrile, 3‐(or 5‐)(2‐phenethyl)‐1,2,4‐triazole3was prepared. Reaction of compounds3with diazomethane afforded 1‐methyl‐3‐(2‐phenethyl)‐1,2,4‐triazole(4)and 1‐methyl‐5‐(2‐phenethyl)‐1,2,4‐triazole(5). Reaction of compound3with methanesulfonyl chloride, benzenesulfonyl chloride orp‐toluenesulfonyl
N. Reghabi, F. Naghashian, Abbas Shafiee
openaire   +3 more sources

1,2,4-Triazole

2006
[288-88-0] C2H3N3 (MW 69.08) InChI = 1S/C2H3N3/c1-3-2-5-4-1/h1-2H,(H,3,4,5) InChIKey = NSPMIYGKQJPBQR-UHFFFAOYSA-N (transacylating agent used for ester and amide synthesis, especially in peptide synthesis; cyclization reactions; oligonucleotide synthesis) Physical Data: mp 120–121 °C; bp 260 °C (dec above 187 °C); fp 140 
Christopher S. Siedem   +1 more
openaire   +2 more sources

ChemInform Abstract: A Novel Route to 1,2,4‐Triazoles.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kumar Ranjan Bhushan   +3 more
openaire   +3 more sources

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